{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:41:12Z","timestamp":1793029272882,"version":"4.5.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["33CM30-124112"],"award-info":[{"award-number":["33CM30-124112"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["33CM30-140336"],"award-info":[{"award-number":["33CM30-140336"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002296","name":"Reuter Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002296","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gerbex-Bourget Foundation","award":["32003B_207881"],"award-info":[{"award-number":["32003B_207881"]}]},{"name":"Gerbex-Bourget Foundation","award":["325130_204361"],"award-info":[{"award-number":["325130_204361"]}]},{"DOI":"10.13039\/501100006388","name":"Geneva University Hospitals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006388","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004362","name":"Swiss Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004362","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gerbex-Bourget Foundation"},{"name":"Schmidheiny Foundation"},{"DOI":"10.13039\/100016545","name":"Roche Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016545","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Eli Lilly"},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Merck Sharpe and Dome"},{"DOI":"10.13039\/100004339","name":"Sanofi-Aventis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006279","name":"St. Jude Medical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006279","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Current guidelines recommend targeting systolic blood pressure (SBP) below 130\u2005mmHg in patients at high cardiovascular risk, including after acute coronary syndrome (ACS), although evidence specific to the post-ACS setting remains limited. We evaluated the prognostic value of SBP measured 1 year after ACS on subsequent cardiovascular outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The ELIPS cohort prospectively enrolled ACS patients across four Swiss tertiary-care centres (2009\u20132017). Patients alive at 1 year with available SBP measurements were included. The association between SBP at 1 year and 3-point major adverse cardiovascular events (MACE; cardiovascular death, non-fatal stroke\/transient ischaemic attack, or non-fatal myocardial infarction) was modelled using restricted cubic splines, adjusted for age, sex, renal function, cardiovascular risk factors, index-event type, coronary revascularization, cardiac rehabilitation, heart failure history, and antihypertensive medication classes. Among 2074 patients (age 63 \u00b1 12 years; 82% male; 53% STEMI), 229 MACE events occurred over a median follow-up of 4.0 years (2.7 per 100 patient-years). The SBP\u2013MACE relationship was non-linear and J-shaped (P-non-linearity = 0.007), with lowest risk between \u223c130 and 140\u2005mmHg (formally estimated nadir 138\u2005mmHg [95% CI 116\u2013152]). Above 140\u2005mmHg, each 5-mmHg increase was associated with a borderline increase in MACE risk (adjusted HR 1.08; 95% CI 1.00\u20131.17). The pattern was broadly consistent across sex, age and hypertension status, with a possible interaction with diabetes that could not be excluded (P-interaction = 0.08).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this large, predominantly male, well-characterized post-ACS cohort, SBP measured 1 year after ACS showed a J-shaped association with cardiovascular risk, with lowest risk at 130\u2013140\u2005mmHg.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag531","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:52:01Z","timestamp":1791546721000},"source":"Crossref","is-referenced-by-count":0,"title":["One-year systolic blood pressure and subsequent cardiovascular outcomes after acute coronary syndrome: insights from a Swiss prospective cohort"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9074-6505","authenticated-orcid":false,"given":"Henri","family":"Lu","sequence":"first","affiliation":[{"name":"Division of Cardiology, Lausanne University Hospital (CHUV), University of Lausanne (UNIL) , Rue du Bugnon 46, Lausanne, Vaud 1011 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6848-4978","authenticated-orcid":false,"given":"C\u00e9dric","family":"Follonier","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Geneva University Hospital (HUG), University of Geneva (UNIGE) , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5063-4848","authenticated-orcid":false,"given":"Louise","family":"Artels","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Lausanne University Hospital (CHUV), University of Lausanne (UNIL) , Rue du Bugnon 46, Lausanne, Vaud 1011 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3212-1272","authenticated-orcid":false,"given":"David","family":"Carballo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Geneva University Hospital (HUG), University of Geneva (UNIGE) , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2493-3505","authenticated-orcid":false,"given":"David","family":"Nanchen","sequence":"additional","affiliation":[{"name":"Center for Primary Care and Public Health (Unisant\u00e9), University of Lausanne , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5259-538X","authenticated-orcid":false,"given":"Thomas F","family":"L\u00fcscher","sequence":"additional","affiliation":[{"name":"Heart Division, Royal Brompton and Harefield Hospitals, GSTT and King's College, London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8124-1767","authenticated-orcid":false,"given":"Christian M","family":"Matter","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, Zurich University Hospital , Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Raeber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center, University Hospital Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2441-5799","authenticated-orcid":false,"given":"Olivier","family":"Muller","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Lausanne University Hospital (CHUV), University of Lausanne (UNIL) , Rue du Bugnon 46, Lausanne, Vaud 1011 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9083-6896","authenticated-orcid":false,"given":"Nicolas","family":"Rodondi","sequence":"additional","affiliation":[{"name":"Institute of Primary Health Care (BIHAM), University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-7630","authenticated-orcid":false,"given":"Gr\u00e9goire","family":"Wuerzner","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Lausanne University Hospital and University of Lausanne , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3178-9131","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Mach","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Geneva University Hospital 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