{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:34:31Z","timestamp":1793086471185,"version":"4.5.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Heart Lung Foundation","award":["2024-1262"],"award-info":[{"award-number":["2024-1262"]}],"id":[{"id":"https:\/\/ror.org\/052261q33","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Swedish government and the county councils","award":["ALFGBG-965404"],"award-info":[{"award-number":["ALFGBG-965404"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Apolipoprotein B (apoB) reflects the number of circulating atherogenic lipoproteins but does not account for differences in particle atherogenicity. Risk-weighted apoB (RW-apoB), which incorporates triglyceride-rich lipoproteins and lipoprotein(a) (Lp(a)), may better capture lipoprotein-driven coronary risk, but its performance across diverse populations remains uncertain. We assessed whether the pre-specified triglyceride\u2014and Lp(a)-weighted information captured by RW-apoB was associated with coronary events beyond apoB and compared the discrimination of RW-apoB and measured apoB across ethnicities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We analysed 40 132 participants with 4509 coronary events from Atherosclerosis Risk in Communities Study, Coronary Artery Risk Development in Young Adults Study, Multi-Ethnic Study of Atherosclerosis, the Framingham Offspring Study, and China Kadoorie Biobank (CKB). RW-apoB was calculated using a pre-specified equation. Mutually adjusted Cox estimates were pooled within ethnic groups using random-effects meta-analysis. Separate single-marker models compared discrimination. Sensitivity analyses included age and sex adjustment, standardized exposures, hard-events, truncated follow-up, and CKB-specific logistic regression. Mean RW-apoB exceeded apoB by approximately 8\u2005mg\/dL in African American and Chinese participants, reflecting higher Lp(a) and triglycerides, respectively. RW-apoB was associated with coronary events conditional on apoB in White, African American, Chinese, and Hispanic participants: hazard ratios per 10\u2005mg\/dL were 1.11 (95% confidence interval 1.05\u20131.18), 1.11 (1.08\u20131.15), 1.08 (1.05\u20131.11), and 1.10 (1.01\u20131.21), respectively. C-indices for RW-apoB vs. apoB were 0.630 vs. 0.617 in White (P &amp;lt; 0.001), 0.606 vs. 0.595 in African American (P\u2005= 0.085), 0.567 vs. 0.554 in Chinese (P = 0.014), and 0.540 vs. 0.535 in Hispanic participants (P = 0.756).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RW-apoB captured lipoprotein-associated risk beyond measured apoB. Discrimination gains were statistically demonstrable in the larger White and Chinese groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag547","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:52:15Z","timestamp":1791978735000},"source":"Crossref","is-referenced-by-count":0,"title":["Risk-weighted apoB and lipoprotein-associated coronary risk across ethnic groups"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3053-6612","authenticated-orcid":false,"given":"Michaela B","family":"Rehman","sequence":"first","affiliation":[{"name":"Cardiology Department, Ramsay Sant\u00e9, M\u00e9dip\u00f4le Lyon-Villeurbanne , 158 rue L\u00e9on Blum, Lyon-Villeurbanne 69100 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