{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:32:10Z","timestamp":1793381530986,"version":"4.5.0"},"reference-count":97,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Universiti Malaya Research Excellence","award":["UMREG033-2024"],"award-info":[{"award-number":["UMREG033-2024"]}],"id":[{"id":"https:\/\/ror.org\/00rzspn62","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the effectiveness of digital health interventions (DHIs) supporting care integration for coronary artery disease (CAD) in improving health outcomes compared to usual care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>For this systematic review, we searched MEDLINE, CINAHL, EBSCO Psychology and Behavioural Sciences Collection, Scopus, and Web of Science from 1 January 1995 to 5 November 2025. We included studies reporting primary data on DHIs supporting care integration for patients with CAD. Primary endpoints were all-cause mortality and readmissions and cardiovascular disease (CVD) events. Secondary endpoints were the control of cardiovascular risk factors. We conducted random-effects meta-analyses in RevMan and assessed risk of bias with Cochrane\u2019s RoB tools. We included 72 studies (23 111 participants), assessing 45 in the meta-analysis. All DHIs supported person-centred care integration (n = 72), while few DHIs addressed clinical care integration (n = 22), professional integration (n = 12), and functional integration (n = 22). Compared to usual care, DHIs supporting care integration had significant reductions in the odds of CVD events [OR: 0.74 (0.59, 0.92), df = 5, P = 0.02], but not in all-cause mortality or readmissions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although this review shows that DHIs supporting care integration were associated with reduced CVD events compared to usual care, the current evidence remains concentrated primarily on person-centred care integration, with limited studies evaluating broader dimensions of care integration at organizational and systemic levels. These findings highlight the important evidence gaps of DHIs in supporting more comprehensive and system-level integration in cardiovascular care. Further research is necessary to understand the influence of DHI modality and function on effectiveness of care integration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag552","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:20:28Z","timestamp":1792408828000},"source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of digital health interventions for care integration in coronary artery disease: a systematic review and meta-analysis"],"prefix":"10.1093","author":[{"given":"Allegra","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Primary Care Medicine, Faculty of Medicine, Universiti Malaya , Kuala Lumpur ,","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2481-9363","authenticated-orcid":false,"given":"Hooi Min","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Primary Care Medicine, Faculty of Medicine, Universiti Malaya , Kuala Lumpur ,","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woei Xian","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Primary Care Medicine, Faculty of Medicine, Universiti Malaya , Kuala Lumpur ,","place":["Malaysia"]},{"name":"Wexham Park Hospital, Frimley Health NHS Foundation Trust , Slough ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Ting","family":"Leong","sequence":"additional","affiliation":[{"name":"Department of Primary Care Medicine, Faculty of Medicine, Universiti Malaya , Kuala Lumpur ,","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1545-7110","authenticated-orcid":false,"given":"Adina","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Department of Primary Care Medicine, Faculty of Medicine, Universiti Malaya , Kuala Lumpur 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