{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T04:39:55Z","timestamp":1787287195322,"version":"build-2736575974"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T00:00:00Z","timestamp":1580428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004362","name":"Swiss Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004362","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>This study compares clinical outcomes of Watchman vs. Amplatzer devices for left atrial appendage closure (LAAC).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Of two real-world registries, the Watchman registry Lichtenfels, Germany, and the Amplatzer registry Bern-Zurich, Switzerland, 303 and 333 consecutive patients, respectively, were included. After a 1:1 propensity score matching, 266 vs. 266 patients were compared by use of the predefined primary efficacy endpoint of stroke, systemic embolism and cardiovascular\/unexplained death, the primary safety endpoint of major peri-procedural complications and major bleeding events at follow-up, and the combined hazard endpoint, a composite of all above-mentioned hazards. Mean age was 75.3\u2009\u00b1\u20097.8 (Watchman) vs. 75.1\u2009\u00b1\u20099.9 (Amplatzer) years, CHA2DS2-VASc score 4.5\u2009\u00b1\u20091.7 vs. 4.5\u2009\u00b1\u20091.5, and HAS-BLED score 3.2\u2009\u00b1\u20091.0 vs. 3.2\u2009\u00b1\u20091.0. At a mean follow-up of 2.4\u2009\u00b1\u20091.3 vs. 2.5\u2009\u00b1\u20091.5\u2009years and 1.322 patient-years, the primary endpoints of efficacy [40\/646, 6.2% [Watchman] vs. 43\/676, 6.4% [Amplatzer]; hazard ratio (HR), 1.02; 95% confidence interval (CI), 0.66\u20131.58; P\u2009=\u20090.92] and safety (33\/646, 5.1% vs. 30\/676, 4.4%; HR, 0.57; 95% CI, 0.29\u20131.11; P\u2009=\u20090.10), as well as the combined hazard endpoint (69\/646, 10.7% vs. 66\/676, 9.8%; HR, 0.80; 95% CI, 0.55\u20131.12; P\u2009=\u20090.26) were similar for both groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study suggests comparable efficacy and safety of the Watchman and Amplatzer devices.<\/jats:p>\n               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