{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T11:36:48Z","timestamp":1788608208945,"version":"build-2803163510"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Using a modified CARTO 3D mapping system, we studied if premature ventricular contractions (PVCs) cause position shifts within the 3D co-ordinate system. We quantified magnitude of the phenomenon and corrected for it, by creating both an activation map that represents the conventional local activation time (LAT) and one corrected for this position shift (hybrid LAT map).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We prospectively enrolled patients planned for PVC ablation. Distances between the earliest LAT, the earliest hybrid-LAT, and the best pacemap positions were calculated in a 3D model. Ablation was performed at the best hybrid-LAT location. Efficacy was evaluated by acute response to ablation as well as clinical outcome on 24-h Holter at 1\u2009year. One hundred and twenty-seven LAT-hybrid pairs were studied in 18 patients (age 48.3\u2009\u00b1\u200918.0\u2009years, 12 female). Baseline PVC burden was 16\u2009\u00b1\u200912%. The mean position shift between LAT-hybrid and its associated LAT position was 8.9\u2009\u00b1\u20095.5\u2009mm. The mean position shift between best LAT-hybrid and best pacemap was 6.2\u2009\u00b1\u20095.0\u2009mm and the mean shift between best conventional LAT and best pacemap was 13.5\u2009\u00b1\u20097.0\u2009mm (P\u2009&amp;lt;\u20090.0001 for all pairwise comparisons). Exclusive targeting of best LAT-hybrid position resulted in acute abolition of PVC activity in all patients. After 1-year follow-up, mean PVC burden reduction was 16% (baseline) to &amp;lt;1%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Premature ventricular contractions cause a position shift in 3D mapping systems compared with the same endocardial position in sinus rhythm. An approach to account for this phenomenon, correct it and target exclusively the adjusted 3D position is feasible and highly efficient in terms of acute and 1-year clinical outcome after radiofrequency ablation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaa013","type":"journal-article","created":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T20:06:44Z","timestamp":1578254804000},"page":"607-612","source":"Crossref","is-referenced-by-count":14,"title":["Premature ventricular contractions cause a position shift in 3D mapping systems: analysis, quantification, and correction by hybrid activation mapping"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1424-114X","authenticated-orcid":false,"given":"Tom","family":"De Potter","sequence":"first","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, OLV Hospital, Aalst, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Iliodromitis","sequence":"first","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, OLV Hospital, Aalst, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Bar-On","sequence":"first","affiliation":[{"name":"Biosense R&D, Yokneam, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etel","family":"Silva Garcia","sequence":"first","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, OLV Hospital, Aalst, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris","family":"Ector","sequence":"first","affiliation":[{"name":"Cardiology Department, Universitaire Ziekenhuizen Leuven, Leuven, 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cardiomyopathy on outcome","volume":"8","author":"Mountantonakis","year":"2011","journal-title":"Heart Rhythm"},{"key":"2020040604554397200_euaa013-B7","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1093\/europace\/euz027","article-title":"Mortality and morbidity reduction after frequent premature ventricular complexes ablation in patients with left ventricular systolic dysfunction","volume":"21","author":"Berruezo","year":"2019","journal-title":"Europace"},{"key":"2020040604554397200_euaa013-B8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.14797\/mdcj-11-2-109","article-title":"Ablating premature ventricular complexes: justification, techniques, and outcomes","volume":"11","author":"Noheria","year":"2015","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"2020040604554397200_euaa013-B9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10840-007-9160-7","article-title":"Efficacy of electroanatomic mapping in the catheter ablation of premature ventricular contractions originating from the right ventricular outflow tract","volume":"19","author":"Yamada","year":"2007","journal-title":"J Interv Card Electrophysiol"},{"key":"2020040604554397200_euaa013-B10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s10840-012-9698-x","article-title":"Advances in management of premature ventricular contractions","volume":"35","author":"Adams","year":"2012","journal-title":"J Interv Card Electrophysiol"},{"key":"2020040604554397200_euaa013-B11","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1111\/pace.13186","article-title":"Ablation of the vanishing PVC, facilitated by quantitative morphology-matching software","volume":"40","author":"Moak","year":"2017","journal-title":"Pacing Clin Electrophysiol"},{"key":"2020040604554397200_euaa013-B12","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.hrthm.2012.02.018","article-title":"Displacement of the target ablation site and ventricles during premature ventricular contractions: relevance for radiofrequency catheter ablation","volume":"9","author":"Andreu","year":"2012","journal-title":"Heart Rhythm"},{"key":"2020040604554397200_euaa013-B13","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1111\/jce.14120","article-title":"Ablation using 3D maps adjusted for spatial displacement of premature ventricular complexes relative to sinus beats: improving precision by correcting for the shift","volume":"30","author":"Steyers","year":"2019","journal-title":"J Cardiovasc Electrophysiol"}],"container-title":["EP 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