{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:56:10Z","timestamp":1790402170566,"version":"4.1.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T00:00:00Z","timestamp":1585526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"CIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Research Scholar Award"},{"name":"Fonds de recherch\u00e9 du Quebec-Sant\u00e9"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Randomized trials suggest reductions in all-cause mortality and heart failure (HF) rehospitalizations with catheter ablation (CA) in patients with atrial fibrillation (AF) and HF. Whether these results can be replicated in a real-world population with long-term follow-up or varies over time is unknown. We sought to evaluate the long-term effectiveness of CA in reducing the incidence of all-cause mortality, HF hospitalizations, stroke, and major bleeding in AF\u2013HF patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In a cohort of patients newly diagnosed with AF\u2013HF in Quebec, Canada (2000\u20132017), CA patients were matched 1:2 to controls on time and frequency of hospitalizations. Confounders were controlled for using inverse probability of treatment weighting. Multivariable Cox models adjusted for the presence of cardiac electronic implantable devices and medication use during follow-up, and the effect of time since CA was modelled with B-splines. For non-fatal outcomes, the Lunn\u2013McNeil approach was used to account for the competing risk of death. Among 101\u2009933 AF\u2013HF patients, 451 underwent CA and were matched to 899 controls. Over a median follow-up of 3.8\u2009years, CA was associated with a statistically significant reduction in all-cause mortality [hazard ratio 0.4 (95% confidence interval 0.2\u20130.7)], but no difference in stroke or major bleeding. The hazard of HF rehospitalization for CA patients, relative to non-CA patients, varied with time since CA (P\u2009=\u20090.01), with a reduction in HF rehospitalizations until approximately 3\u2009years post-CA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Compared with matched non-CA patients, CA was associated with a long-term reduction in all-cause mortality and a reduction in HF rehospitalizations until 3\u2009years post-CA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaa036","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T20:10:57Z","timestamp":1581451857000},"page":"739-747","source":"Crossref","is-referenced-by-count":14,"title":["Long-term effectiveness of catheter ablation in patients with atrial fibrillation and heart failure"],"prefix":"10.1093","volume":"22","author":[{"given":"Michelle","family":"Samuel","sequence":"first","affiliation":[{"name":"Centre for Outcomes Research and Evaluation, Research Institute of McGill University Health Centre, Montreal, Canada"},{"name":"Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3172-3952","authenticated-orcid":false,"given":"Michal","family":"Abrahamowicz","sequence":"first","affiliation":[{"name":"Centre for Outcomes Research and Evaluation, Research Institute of McGill University Health Centre, Montreal, Canada"},{"name":"Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, 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