{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:20:01Z","timestamp":1790695201799,"version":"4.1.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"crossref","award":["2015T058"],"award-info":[{"award-number":["2015T058"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006662","name":"NIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014461","name":"Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014461","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Netherlands Organization for Scientific Research","award":["040.11.586"],"award-info":[{"award-number":["040.11.586"]}]},{"DOI":"10.13039\/501100014470","name":"Netherlands Heart Institute","doi-asserted-by":"publisher","award":["06901"],"award-info":[{"award-number":["06901"]}],"id":[{"id":"10.13039\/501100014470","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UMC Utrecht Alexandre Suerman Stipend"},{"name":"Canadian Heart Rhythm Society George Mines Traveling Fellowship"},{"name":"Montreal Heart Institute Foundation \u2018Bal du Coeur\u2019 bursary"},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dr Francis P. Chiaramonte Private Foundation"},{"name":"Bogle Foundation"},{"name":"Healing Hearts Foundation"},{"name":"Patrick J. Harrison Family"},{"name":"Peter French Memorial Foundation"},{"name":"Wilmerding Endowments"},{"name":"Leonie-Wild Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Arrhythmogenic right ventricular cardiomyopathy (ARVC) is diagnosed by a complex set of clinical tests as per 2010 Task Force Criteria (TFC). Avoiding misdiagnosis is crucial to prevent sudden cardiac death as well as unnecessary implantable cardioverter-defibrillator implantations. This study aims to validate the overall performance of the TFC in a real-world cohort of patients referred for ARVC evaluation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We included patients consecutively referred to our centres for ARVC evaluation. Patients were diagnosed by consensus of three independent clinical experts. Using this as a reference standard, diagnostic performance was measured for each individual criterion as well as the overall TFC classification. Of 407 evaluated patients (age 38\u2009\u00b1\u200917 years, 51% male), the expert panel diagnosed 66 (16%) with ARVC. The clinically observed TFC was false negative in 7\/66 (11%) patients and false positive in 10\/69 (14%) patients. Idiopathic outflow tract ventricular tachycardia was the most common alternative diagnosis. While the TFC performed well overall (sensitivity and specificity 92%), signal-averaged electrocardiogram (SAECG, P\u2009=\u20090.43), and several family history criteria (P\u2009\u2265\u20090.17) failed to discriminate. Eliminating these criteria reduced false positives without increasing false negatives (net reclassification improvement 4.3%, P\u2009=\u20090.019). Furthermore, all ARVC patients met at least one electrocardiogram (ECG) or arrhythmia criterion (sensitivity 100%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The TFC perform well but are complex and can lead to misdiagnosis. Simplification by eliminating SAECG and several family history criteria improves diagnostic accuracy. Arrhythmogenic right ventricular cardiomyopathy can be ruled out using ECG and arrhythmia criteria alone, hence these tests may serve as a first-line screening strategy among at-risk individuals.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaa039","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T04:30:52Z","timestamp":1580790652000},"page":"787-796","source":"Crossref","is-referenced-by-count":66,"title":["Diagnosing arrhythmogenic right ventricular cardiomyopathy by 2010 Task Force Criteria: clinical performance and simplified practical implementation"],"prefix":"10.1093","volume":"22","author":[{"given":"Laurens P","family":"Bosman","sequence":"first","affiliation":[{"name":"Netherlands Heart Institute, Moreelsepark 1, 3511 EP Utrecht, the Netherlands"},{"name":"Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7489-8744","authenticated-orcid":false,"given":"Julia","family":"Cadrin-Tourigny","sequence":"first","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5820-4610","authenticated-orcid":false,"given":"Mimount","family":"Bourfiss","sequence":"first","affiliation":[{"name":"Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounes","family":"Aliyari Ghasabeh","sequence":"first","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apurva","family":"Sharma","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal","family":"Tichnell","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2059-1509","authenticated-orcid":false,"given":"Rob W","family":"Roudijk","sequence":"first","affiliation":[{"name":"Netherlands Heart Institute, Moreelsepark 1, 3511 EP Utrecht, the Netherlands"},{"name":"Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7870-8584","authenticated-orcid":false,"given":"Brittney","family":"Murray","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harikrishna","family":"Tandri","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4059-3800","authenticated-orcid":false,"given":"Paul","family":"Khairy","sequence":"first","affiliation":[{"name":"Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihab R","family":"Kamel","sequence":"first","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan L","family":"Zimmerman","sequence":"first","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes B","family":"Reitsma","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Julius Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1692-8669","authenticated-orcid":false,"given":"Folkert W","family":"Asselbergs","sequence":"first","affiliation":[{"name":"Netherlands Heart Institute, Moreelsepark 1, 3511 EP Utrecht, the Netherlands"},{"name":"Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands"},{"name":"Faculty of Population Health Sciences, Institute of Cardiovascular Science, University College London, London, UK"},{"name":"Health Data Research UK and Institute of Health Informatics, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3854-6749","authenticated-orcid":false,"given":"J Peter","family":"van Tintelen","sequence":"first","affiliation":[{"name":"Netherlands Heart Institute, Moreelsepark 1, 3511 EP Utrecht, the Netherlands"},{"name":"Department of Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen F","family":"van der Heijden","sequence":"first","affiliation":[{"name":"Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard N W","family":"Hauer","sequence":"first","affiliation":[{"name":"Netherlands Heart Institute, Moreelsepark 1, 3511 EP Utrecht, the Netherlands"},{"name":"Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9262-9433","authenticated-orcid":false,"given":"Hugh","family":"Calkins","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia A","family":"James","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4694-4790","authenticated-orcid":false,"given":"Anneline S J M","family":"te Riele","sequence":"first","affiliation":[{"name":"Netherlands Heart Institute, Moreelsepark 1, 3511 EP Utrecht, the Netherlands"},{"name":"Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"2020050704582406200_euaa039-B1","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/S0140-6736(09)60256-7","article-title":"Arrhythmogenic right ventricular cardiomyopathy","volume":"373","author":"Basso","year":"2009","journal-title":"Lancet"},{"key":"2020050704582406200_euaa039-B2","first-page":"3227","article-title":"Treatment of arrhythmogenic right ventricular cardiomyopathy\/dysplasia: an international task force consensus statement","volume":"36","author":"Corrado","year":"2015","journal-title":"Eur Heart J"},{"key":"2020050704582406200_euaa039-B3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1136\/hrt.71.3.215","article-title":"Diagnosis of arrhythmogenic right ventricular dysplasia\/cardiomyopathy. 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