{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:08:55Z","timestamp":1780351735952,"version":"3.54.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Medtronic International Trading S\u00e0rl"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The GOLD AF Registry has been designed to prospectively assess the population, indications, and outcomes using second-generation phased radiofrequency (RF) ablation (pulmonary vein ablation catheter GOLD) in a global examination of standard-of-care use for the treatment of paroxysmal and persistent atrial fibrillation (AF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>GOLD AF (NCT02433613) is a prospective, observational, multi-centre registry designed to characterize efficacy and safety of phased RF ablation in patients with AF. The primary endpoint was freedom from AF recurrence at 12-month follow-up after a 90-day blanking period. Ancillary objectives include safety, procedural efficiency, and quality of life (QoL). The QoL assessment using the Atrial Fibrillation Effect on QualiTy-of-Life (AFEQT) and the European Heart Rhythm Association (EHRA) Score of AF-related symptoms was collected at baseline and 12\u2009months. In total, 1054 patients were included in this analysis (age 60.6, 67.6% male, 26.5% PersAF). Kaplan\u2013Meier estimate of freedom from AF recurrence was 77.7% at 12\u2009months. Peri-procedural device or procedure-related complications were observed in 26 (2.5%) patients, with a low stroke rate of 0.3%. One-year post-ablation, the EHRA AF Symptom score decreased in 68% of patients. The AFEQT score improvement was observed in 88.4% and 90.4% of patients who completed the questionnaire in-person or interviewed by phone at 12\u2009month follow-up, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Phased RF ablation for the treatment of paroxysmal and persistent AF demonstrated a 77.7% freedom from AF recurrence at 12 months in addition to a significant reduction in arrhythmia symptoms and clinically meaningful improved QoL. Low peri-procedural complication rate of &amp;lt;3% was reported.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaa042","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T12:09:37Z","timestamp":1581422977000},"page":"888-896","source":"Crossref","is-referenced-by-count":20,"title":["Paroxysmal and persistent atrial fibrillation ablation outcomes with the pulmonary vein ablation catheter GOLD duty-cycled phased radiofrequency ablation catheter: quality of life and 12-month efficacy results from the GOLD Atrial Fibrillation Registry"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-4220","authenticated-orcid":false,"given":"Lucas","family":"Boersma","sequence":"first","affiliation":[{"name":"Department of Cardiology, St. Antonius Ziekenhuis, PO Box 2500, 3430 EM, Nieuwegein, The Netherlands"},{"name":"Cardiology Department, Amsterdam, UMC, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Ko\u017aluk","sequence":"first","affiliation":[{"name":"Cardiology Department, Chair and Department of Cardiology, Medical University of Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9518-5877","authenticated-orcid":false,"given":"Giampiero","family":"Maglia","sequence":"first","affiliation":[{"name":"Cardiology Department, Pugliese-Ciaccio Hospital, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7374-0152","authenticated-orcid":false,"given":"Jo\u00e3o","family":"de Sousa","sequence":"first","affiliation":[{"name":"Cardiology Department, Centro Hospitalar Lisboa Norte\u2014Hospital de Santa Maria E.P.E., Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Grebe","sequence":"first","affiliation":[{"name":"Cardiology Department, Evangelisches Krankenhaus D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Eckardt","sequence":"first","affiliation":[{"name":"Cardiology Department, Universit\u00e4tsklinikum M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4066-9206","authenticated-orcid":false,"given":"Robert B","family":"Hokanson","sequence":"first","affiliation":[{"name":"Cardiology Department, Medtronic, Inc"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A","family":"Hemingway","sequence":"first","affiliation":[{"name":"Cardiology Department, Medtronic, Inc"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Ostern","sequence":"first","affiliation":[{"name":"Cardiology Department, Medtronic, Inc"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8042-1029","authenticated-orcid":false,"given":"Hyoung-Seob","family":"Park","sequence":"first","affiliation":[{"name":"Cardiology Department, Keimyung University Dongsan Hospital, Daegu, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5639-5708","authenticated-orcid":false,"given":"Giovanni","family":"Rovaris","sequence":"first","affiliation":[{"name":"Cardiology Department, A.O. Osped. S.Gerardo, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Arribas","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Universitario 12 de Octubre, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Scharf","sequence":"first","affiliation":[{"name":"Cardiology Department, Hirslanden-Klinik Im Park Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Csan\u00e1di","sequence":"first","affiliation":[{"name":"Cardiology Department, University of Debrecen, Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2945-5992","authenticated-orcid":false,"given":"\u00c1ngel","family":"Arenal","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Laurenzi","sequence":"first","affiliation":[{"name":"Cardiology Department, Ospedale S. Camillo, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0215-6637","authenticated-orcid":false,"given":"Martijn","family":"Klaver","sequence":"first","affiliation":[{"name":"Department of Cardiology, St. Antonius Ziekenhuis, PO Box 2500, 3430 EM, Nieuwegein, The Netherlands"},{"name":"Cardiology Department, Amsterdam, UMC, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Goette","sequence":"first","affiliation":[{"name":"Cardiology Department, St. Vincenz-Krankenhaus Paderborn, Medizinische Klinik II, Paderborn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"key":"2020060505002025700_euaa042-B1"},{"key":"2020060505002025700_euaa042-B2","first-page":"e199","article-title":"2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation","volume":"130","author":"January","year":"2014","journal-title":"Circulation"},{"key":"2020060505002025700_euaa042-B3","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euw295","article-title":"2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS","volume":"18","author":"Kirchhof","year":"2016","journal-title":"Europace"},{"key":"2020060505002025700_euaa042-B4","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1161\/01.CIR.0000157153.30978.67","article-title":"Worldwide survey on the methods, efficacy, and safety of catheter ablation for human atrial fibrillation","volume":"111","author":"Cappato","year":"2005","journal-title":"Circulation"},{"key":"2020060505002025700_euaa042-B5","first-page":"48","article-title":"Results from a multicentre comparison of cryoballoon vs. radiofrequency ablation for paroxysmal atrial fibrillation: is cryoablation more reproducible?","volume":"19","author":"Providencia","year":"2017","journal-title":"Europace"},{"key":"2020060505002025700_euaa042-B6","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.hrthm.2016.02.012","article-title":"Predictability of lesion durability for AF ablation using phased radiofrequency: power, temperature, and duration impact creation of transmural lesions","volume":"13","author":"Hocini","year":"2016","journal-title":"Heart Rhythm"},{"key":"2020060505002025700_euaa042-B7","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.hrthm.2011.03.051","article-title":"Randomized study comparing duty-cycled bipolar and unipolar radiofrequency with point-by-point ablation in pulmonary vein isolation","volume":"8","author":"Bittner","year":"2011","journal-title":"Heart Rhythm"},{"key":"2020060505002025700_euaa042-B8","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.hrthm.2008.08.037","article-title":"Pulmonary vein isolation by duty-cycled bipolar and unipolar radiofrequency energy with a multielectrode ablation catheter","volume":"5","author":"Boersma","year":"2008","journal-title":"Heart Rhythm"},{"key":"2020060505002025700_euaa042-B9","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1540-8167.2009.01640.x","article-title":"Results of short-term and long-term pulmonary vein isolation for paroxysmal atrial fibrillation using duty-cycled bipolar and unipolar radiofrequency energy","volume":"21","author":"Wieczorek","year":"2010","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2020060505002025700_euaa042-B10","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.jacc.2009.07.009","article-title":"Ablation of persistent atrial fibrillation using multielectrode catheters and duty-cycled radiofrequency energy","volume":"54","author":"Scharf","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2020060505002025700_euaa042-B11","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1111\/jce.12752","article-title":"The biophysics of passive convective cooling during catheter ablation with gold versus platinum electrodes and multielectrode phased radiofrequency energy delivery","volume":"26","author":"Haines","year":"2015","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2020060505002025700_euaa042-B12","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1161\/CIRCEP.113.000612","article-title":"Evaluation and reduction of asymptomatic cerebral embolism in ablation of atrial fibrillation, but high prevalence of chronic silent infarction results of the evaluation of reduction of asymptomatic cerebral embolism trial","volume":"6","author":"Verma","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2020060505002025700_euaa042-B13","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/europace\/euv385","article-title":"Low rate of asymptomatic cerebral embolism and improved procedural efficiency with the novel pulmonary vein ablation catheter GOLD: results of the PRECISION GOLD trial","volume":"18","author":"De Greef","year":"2016","journal-title":"Europace"},{"key":"2020060505002025700_euaa042-B14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/CIRCEP.110.958033","article-title":"Development and validation of the Atrial Fibrillation Effect on QualiTy-of-Life (AFEQT) Questionnaire in patients with atrial fibrillation","volume":"4","author":"Spertus","year":"2011","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2020060505002025700_euaa042-B15","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1093\/europace\/eus188","article-title":"European survey on efficacy and safety of duty-cycled radiofrequency ablation for atrial fibrillation","volume":"14","author":"Scharf","year":"2012","journal-title":"Europace"},{"key":"2020060505002025700_euaa042-B16","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ijcard.2017.04.035","article-title":"Circumferential pulmonary vein isolation with second-generation multipolar catheter in patients with paroxysmal or persistent atrial fibrillation: procedural and one-year follow-up results","volume":"241","author":"Spitzer","year":"2017","journal-title":"Int J Cardiol"},{"key":"2020060505002025700_euaa042-B17","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1056\/NEJMoa1602014","article-title":"Cryoballoon or radiofrequency ablation for paroxysmal atrial fibrillation","volume":"374","author":"Kuck","year":"2016","journal-title":"N Engl J Med"},{"key":"2020060505002025700_euaa042-B18","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1056\/NEJMoa1408288","article-title":"Approaches to catheter ablation for persistent atrial fibrillation","volume":"372","author":"Verma","year":"2015","journal-title":"N Engl J Med"},{"key":"2020060505002025700_euaa042-B19","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/europace\/euz055","article-title":"EHRA White Paper: knowledge gaps in arrhythmia management status 2019","volume":"21","author":"Goette","year":"2019","journal-title":"Europace"},{"key":"2020060505002025700_euaa042-B20","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ahj.2013.04.015","article-title":"Interpreting changes in quality of life in atrial fibrillation: how much change is meaningful?","volume":"166","author":"Dorian","year":"2013","journal-title":"Am Heart J"},{"key":"2020060505002025700_euaa042-B21","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1093\/europace\/eur204","article-title":"Pulmonary vein isolation and left atrial complex-fractionated atrial electrograms ablation for persistent atrial fibrillation with phased radio frequency energy and multi-electrode catheters: efficacy and safety during 12 months follow-up","volume":"13","author":"Mulder","year":"2011","journal-title":"Europace"},{"key":"2020060505002025700_euaa042-B22","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/europace\/euv355","article-title":"Data on procedural handling and complications of pulmonary vein isolation using the pulmonary vein ablation catheter GOLD\u00ae","volume":"18","author":"Leitz","year":"2016","journal-title":"Europace"}],"container-title":["EP Europace"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/europace\/article-pdf\/22\/6\/888\/33341704\/euaa042.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/europace\/article-pdf\/22\/6\/888\/33341704\/euaa042.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T08:11:53Z","timestamp":1591431113000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/22\/6\/888\/5812743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,27]]},"references-count":22,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,3,27]]},"published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euaa042","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,6]]},"published":{"date-parts":[[2020,3,27]]}}}