{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T20:28:05Z","timestamp":1782764885753,"version":"3.54.5"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Rio Hortega Research Grant","award":["CM17\/00062"],"award-info":[{"award-number":["CM17\/00062"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Economia y Competitividad","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Patients with infective endocarditis (IE) frequently have cardiac implantable electronic devices (CIEDs). Here, we aim to define the clinical profile and prognostic factors of IE in these patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Infective endocarditis cases were prospectively identified in the Spanish National Endocarditis Registry. From 3996 IE, 708 (17.7%) had a CIED and 424 CIED-related IE (lead vegetation). Patients with a CIED were older (68\u2009\u00b1\u200911 vs. 73\u2009\u00b1\u20098\u2009years); had more comorbidities {pulmonary disease [176 (24.8%) vs. 545 (16.7%)], renal disease [239 (33.8%) vs. 740 (22.7%)], diabetes [248 (35.0%) vs. 867 (26.6%)], and heart failure [348 (49.2%) vs. 978 (29.9%)]}; and fewer complications {intracardiac destruction [106 (15%) vs. 1077 (33.1%)], heart failure [215 (30.3%) vs. 1340 (41.1%)], embolism [107 (15.1%) vs. 714 (21.9%)], and neurological involvement [77 (10.8%) vs. 702 (21.5%)]} (all P-values &amp;lt;0.001) in comparison to subjects without a CIED. In-hospital mortality was similar in patients with and without CIED [171 (24.2%) vs. 881 (27.0%), P\u2009=\u20090.82]. In subjects with a CIED, CIED-related IE was independently associated with in-hospital survival: odds ratio (OR) 0.4 [95% confidence interval (CI) 0.3\u20130.7, P\u2009=\u20090.001]. Surgery was independently associated with in-hospital survival in CIED-related IE: OR 0.4 (95% CI 0.2\u20130.7, P\u2009=\u20090.004); but not in subjects with valve IE and no CIED lead involvement: OR 0.9 (95% CI 0.5\u20131.7, P\u2009=\u20090.77).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Over a sixth of IE patients have a CIED. This group of patients is older, with more comorbidities and fewer IE-related complications in comparison to subjects without a CIED. In-hospital mortality was similar in patients with and without a CIED.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaa076","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T20:29:19Z","timestamp":1584044959000},"page":"1062-1070","source":"Crossref","is-referenced-by-count":47,"title":["Infective endocarditis in patients with cardiac implantable electronic devices: a nationwide study"],"prefix":"10.1093","volume":"22","author":[{"given":"Roberto","family":"Mateos Gait\u00e1n","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, CIBERCV, Calle Doctor Esquerdo, 46, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Boix-Palop","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases and Microbiology, Department of Internal Medicine, Hospital Universitari M\u00fatua de Terrassa, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Mu\u00f1oz Garc\u00eda","sequence":"first","affiliation":[{"name":"Clinical Unit of Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Gregorio Mara\u00f1\u00f3n Health Research Institute, CIBER Enfermedades Respiratorias-CIBERES, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A","family":"Mestres","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Mar\u00edn Arriaza","sequence":"first","affiliation":[{"name":"Clinical Unit of Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Gregorio Mara\u00f1\u00f3n Health Research Institute, CIBER Enfermedades Respiratorias-CIBERES, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Pedraz Prieto","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ar\u00edstides","family":"de Alarc\u00f3n Gonzalez","sequence":"first","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine Infectious Diseases, Research Group Institute of Biomedicine of Seville (IBiS), University of Seville\/CSIC\/University Hospital Virgen del Roc\u00edo, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Encarnaci\u00f3n","family":"Guti\u00e9rrez Carretero","sequence":"first","affiliation":[{"name":"Cardiac Surgery Department, University of Sevilla\/CSIC\/University Hospital Virgen del Roc\u00edo Seville, Institute of Biomedicine\u2014Sevilla (IBiS), CIBERCV, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Hern\u00e1ndez Meneses","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Goenaga S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Hospital Universitario Donosti, San Sebasti\u00e1n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Cobo Belaustegui","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Marqu\u00e9s de Valdecilla, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Oteo Revuelta","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Hospital Universitario San Pedro, Centre for Biomedical Research La Rioja 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