{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:09:21Z","timestamp":1788959361179,"version":"build-2803163510"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370293"],"award-info":[{"award-number":["81370293"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470023\/81100125"],"award-info":[{"award-number":["81470023\/81100125"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["CYMY-2017-03"],"award-info":[{"award-number":["CYMY-2017-03"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007497","name":"Biosense-Webster, Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007497","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Circumferential pulmonary vein isolation can be effective as sole treatment for persistent atrial fibrillation. However, identifying those patients who will respond to this therapy remains a challenge. We investigated the clinical value of the sequential low-dose ibutilide test for identifying patients with persistent atrial fibrillation in whom pulmonary vein isolation is effective as sole therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In a prospective cohort of 180 consecutive patients with persistent atrial fibrillation, intravenous low-dose (0.004\u2009mg\/kg) ibutilide was administered 3\u2009days before ablation and after the completion of circumferential pulmonary vein isolation. In patients in whom ibutilide did not terminate atrial fibrillation pre-procedurally, but successfully terminated it intraprocedurally, no further atrial substrate modification was performed. Pre-procedural low-dose ibutilide failed to terminate the arrhythmia in all patients with persistent atrial fibrillation, while pulmonary vein isolation \u00b1 low-dose ibutilide terminated persistent atrial fibrillation in 55 (30.6%) of them (PsAF group 1). The remaining 125 (69.4%) patients underwent electrogram-based ablation (PsAF Group 2). The control group comprised 379 consecutive patients with paroxysmal atrial fibrillation who underwent pulmonary vein isolation over the same period. At 24\u2009months follow-up, 39 (70.9%) patients in PsAF Group 1 and 276 (72.8%) patients in the control group were free from atrial tachyarrhythmias (P = NS); the arrhythmia-free rates in both groups were higher than that in PsAF group 2 (58.4%, P\u2009=\u20090.005).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The sequential low-dose ibutilide test is a simple method for identifying patients with persistent atrial fibrillation in whom pulmonary vein isolation alone is an appropriate treatment strategy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaa095","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T11:08:54Z","timestamp":1587726534000},"page":"1197-1205","source":"Crossref","is-referenced-by-count":7,"title":["Identification of circumferential pulmonary vein isolation responders among patients with persistent atrial fibrillation: clinical value of the sequential low-dose ibutilide test"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8022-524X","authenticated-orcid":false,"given":"Shu-Nan","family":"He","sequence":"first","affiliation":[{"name":"Heart Center, Beijing Chaoyang Hospital, Capital Medical University, No.8 Gong Ti Nan Road, Chaoyang District, Beijing 100020, China"},{"name":"Heart Center, Beijing Luhe Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Tian","sequence":"additional","affiliation":[{"name":"Heart Center, Beijing Chaoyang Hospital, Capital Medical University, No.8 Gong Ti Nan Road, Chaoyang District, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Shi","sequence":"additional","affiliation":[{"name":"Heart Center, Beijing Chaoyang Hospital, Capital Medical University, No.8 Gong Ti Nan Road, Chaoyang District, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Jiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Heart Center, Beijing Chaoyang Hospital, Capital Medical University, No.8 Gong Ti Nan Road, Chaoyang District, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Qia","family":"Xie","sequence":"additional","affiliation":[{"name":"Heart Center, Beijing Chaoyang Hospital, Capital Medical University, No.8 Gong Ti Nan Road, Chaoyang District, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Xun","family":"Li","sequence":"additional","affiliation":[{"name":"Heart Center, Beijing Chaoyang Hospital, Capital Medical University, No.8 Gong Ti Nan Road, Chaoyang District, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Heart Center, 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