{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:44:40Z","timestamp":1771263880757,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,6,28]],"date-time":"2020-06-28T00:00:00Z","timestamp":1593302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims\u2003<\/jats:title>\n                  <jats:p>Cardiac resynchronization therapy with (CRTD) or without (CRTP) defibrillator is recommended in selected patient with systolic chronic heart failure and wide QRS. There is no guideline firmly indicating choice between CRTP and CRTD in primary prevention, particularly in older patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results\u2003<\/jats:title>\n                  <jats:p>Based on the French administrative hospital-discharge database, information was collected from 2010 to 2017 for all patients implanted with CRTP or CRTD in primary prevention. Outcome analyses were undertaken in the total study population and in propensity-matched samples. During follow-up (913\u2009days, SD 841, median 701, IQR 151\u20131493), 45\u00a0697 patients were analysed (CRTP 19\u00a0266 and CRTD 26\u00a0431). Incidence rate (%patient\/year) of all-cause mortality was higher in CRTP patients (11.6%) than in CRTD patients (6.8%) [hazard ratio (HR) 1.70, 95% confidence interval (CI) 1.63\u20131.76, P\u2009&amp;lt;\u20090.001]. After propensity-matched analyses, mortality of patients over 75\u2009years old with non-ischaemic cardiomyopathy (NICM) was not different with CRTP and CRTD (HR 0.93, 95% CI 0.80\u20131.09, P\u2009=\u20090.39). The CRTP patients under 75 years old with NICM had a higher mortality than CRTD patients (HR 1.22, 95% CI 1.03\u20131.45, P\u2009=\u20090.02). Mortality rate was also higher with CRTP than with CRTD irrespectively of age in patients with ischaemic cardiomyopathy (ICM) (&amp;lt;75 years old: HR 1.22, 95% CI 1.08\u20131.37, P\u2009=\u20090.01; \u226575 years old: HR 1.13, 95% CI 1.04\u20131.22, P\u2009=\u20090.003).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion\u2003<\/jats:title>\n                  <jats:p>In this real-life study, CRTD was associated with a significantly lower all-cause mortality than CRTP in patients with ICM and in patients with NICM under 75 years old. Patients over 75 years old with NICM did not have lower mortality with primary prevention CRTD implantation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaa096","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T19:10:52Z","timestamp":1585941052000},"page":"1224-1233","source":"Crossref","is-referenced-by-count":21,"title":["Mortality and cardiac resynchronization therapy with or without defibrillation in primary prevention"],"prefix":"10.1093","volume":"22","author":[{"given":"Matthieu","family":"Gras","sequence":"first","affiliation":[{"name":"Service de Cardiologie, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Tours, EA7505 Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Bisson","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Tours, EA7505 Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Bodin","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Tours, EA7505 Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Herbert","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Tours, EA7505 Tours, France"},{"name":"Service d\u2019information m\u00e9dicale, d\u2019\u00e9pid\u00e9miologie et d\u2019\u00e9conomie de la sant\u00e9, Centre Hospitalier Universitaire et Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Tours, EA7505 Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Babuty","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Tours, EA7505 Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Pierre","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Tours, EA7505 Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Clementy","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Tours, EA7505 Tours, 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