{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T08:06:17Z","timestamp":1784966777169,"version":"3.55.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,6,28]],"date-time":"2020-06-28T00:00:00Z","timestamp":1593302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 research and innovation programme"},{"name":"ESCAPE-NET","award":["733381"],"award-info":[{"award-number":["733381"]}]},{"name":"Netherlands CardioVascular Research Initiative"},{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012524","name":"Dutch Federation of University Medical Centers","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012524","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organization for Health Research and Development","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001722","name":"Royal Netherlands Academy of Sciences","doi-asserted-by":"crossref","award":["CVON-2018-30"],"award-info":[{"award-number":["CVON-2018-30"]}],"id":[{"id":"10.13039\/501100001722","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001722","name":"Royal Netherlands Academy of Sciences","doi-asserted-by":"crossref","award":["CVON-2017-15"],"award-info":[{"award-number":["CVON-2017-15"]}],"id":[{"id":"10.13039\/501100001722","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Netherlands Heart Foundation","award":["2013T034"],"award-info":[{"award-number":["2013T034"]}]},{"DOI":"10.13039\/100008894","name":"Stryker","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008894","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"Trygfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Conflicting results have been reported regarding the effect of beta-blockers on first-registered heart rhythm in out-of-hospital cardiac arrest (OHCA). We aimed to establish whether the use of beta-blockers influences first-registered rhythm in OHCA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We included patients with OHCA of presumed cardiac cause from two large independent OHCA-registries from Denmark and the Netherlands. Beta-blocker use was defined as exposure to either non-selective beta-blockers, \u03b21-selective beta-blockers, or \u03b1-\u03b2-dual-receptor blockers within 90\u2009days prior to OHCA. We calculated odds ratios (ORs) for the association of beta-blockers with first-registered heart rhythm using multivariable logistic regression. We identified 23\u00a0834 OHCA-patients in Denmark and 1584 in the Netherlands: 7022 (29.5%) and 519 (32.8%) were treated with beta-blockers, respectively. Use of non-selective beta-blockers, but not \u03b21-selective blockers, was more often associated with non-shockable rhythm than no use of beta-blockers [Denmark: OR 1.93, 95% confidence interval (CI) 1.48\u20132.52; the Netherlands: OR 2.52, 95% CI 1.15\u20135.49]. Non-selective beta-blocker use was associated with higher proportion of pulseless electrical activity (PEA) than of shockable rhythm (OR 2.38, 95% CI 1.01\u20135.65); the association with asystole was of similar magnitude, although not statistically significant compared with shockable rhythm (OR 2.34, 95% CI 0.89\u20136.18; data on PEA and asystole were only available in the Netherlands). Use of \u03b1-\u03b2-dual-receptor blockers was significantly associated with non-shockable rhythm in Denmark (OR 1.21; 95% CI 1.03\u20131.42) and not significantly in the Netherlands (OR 1.37; 95% CI 0.61\u20133.07).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Non-selective beta-blockers, but not \u03b21-selective beta-blockers, are associated with non-shockable rhythm in OHCA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaa124","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T19:13:31Z","timestamp":1588101211000},"page":"1206-1215","source":"Crossref","is-referenced-by-count":4,"title":["Association of beta-blockers and first-registered heart rhythm in out-of-hospital cardiac arrest: real-world data from population-based cohorts across two European countries"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0760-8372","authenticated-orcid":false,"given":"Carlo A","family":"Barcella","sequence":"first","affiliation":[{"name":"Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talip E","family":"Eroglu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel","family":"Hulleman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asger","family":"Granfeldt","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick C","family":"Souverein","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grimur H","family":"Mohr","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolph W","family":"Koster","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads","family":"Wissenberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthonius","family":"de Boer","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Torp-Pedersen","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark"},{"name":"Department of Clinical Investigation and Cardiology, Nordsjaellands Hospital, Hiller\u00f8d, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Folke","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke T","family":"Blom","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar H","family":"Gislason","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark"},{"name":"The Danish Heart Foundation, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanno L","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"},{"name":"Netherlands Heart Institute, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the ESCAPE-NET Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,28]]},"reference":[{"key":"2020080405004377600_euaa124-B1","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1001\/jama.288.23.3008","article-title":"Changing incidence of out-of-hospital ventricular fibrillation, 1980-2000","volume":"288","author":"Cobb","year":"2002","journal-title":"JAMA"},{"key":"2020080405004377600_euaa124-B2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.resuscitation.2015.07.010","article-title":"Causes for the declining proportion of ventricular fibrillation in out-of-hospital cardiac arrest","volume":"96","author":"Hulleman","year":"2015","journal-title":"Resuscitation"},{"key":"2020080405004377600_euaa124-B3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.resuscitation.2003.11.003","article-title":"Decrease in the occurrence of ventricular fibrillation as the initially observed arrhythmia after out-of-hospital cardiac arrest during 11 years in Sweden","volume":"60","author":"Herlitz","year":"2004","journal-title":"Resuscitation"},{"key":"2020080405004377600_euaa124-B4","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.ehj.2004.06.002","article-title":"Expert consensus document on beta-adrenergic receptor blockers","volume":"25","author":"L\u00f3pez-Send\u00f3n","year":"2004","journal-title":"Eur Heart J"},{"key":"2020080405004377600_euaa124-B5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1080\/14017430510008989","article-title":"Nationwide trends in the prescription of beta-blockers and angiotensin-converting enzyme inhibitors after myocardial infarction in Denmark, 1995-2002","volume":"39","author":"Gislason","year":"2005","journal-title":"Scand Cardiovasc J"},{"key":"2020080405004377600_euaa124-B6","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.resuscitation.2007.08.022","article-title":"Beta-blocker use and the changing epidemiology of out-of-hospital cardiac arrest rhythms","volume":"76","author":"Youngquist","year":"2008","journal-title":"Resuscitation"},{"key":"2020080405004377600_euaa124-B7","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.ahj.2015.06.027","article-title":"Association of prior \u03b2-blocker use and the outcomes of patients with out-of-hospital cardiac arrest","volume":"170","author":"Czarnecki","year":"2015","journal-title":"Am Heart J"},{"key":"2020080405004377600_euaa124-B8","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.hrthm.2012.12.002","article-title":"Antipsychotic drugs are associated with pulseless electrical activity: the Oregon Sudden Unexpected Death Study","volume":"10","author":"Teodorescu","year":"2013","journal-title":"Heart Rhythm"},{"key":"2020080405004377600_euaa124-B9","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.resuscitation.2016.08.024","article-title":"Clinical predictors of shockable versus non-shockable rhythms in patients with out-of-hospital cardiac arrest","volume":"108","author":"Granfeldt","year":"2016","journal-title":"Resuscitation"},{"key":"2020080405004377600_euaa124-B10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.resuscitation.2016.12.021","article-title":"Incidence and survival outcome according to heart rhythm during resuscitation attempt in out-of-hospital cardiac arrest patients with presumed cardiac etiology","volume":"114","author":"Rajan","year":"2017","journal-title":"Resuscitation"},{"key":"2020080405004377600_euaa124-B11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/eurheartj\/ehx758","article-title":"European Sudden Cardiac Arrest network: towards Prevention, Education and New Effective Treatments (ESCAPE-NET","volume":"39","author":"Tan","year":"2018","journal-title":"Eur Heart J"},{"key":"2020080405004377600_euaa124-B12","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.resuscitation.2014.06.008","article-title":"Survival after out-of-hospital cardiac arrest in relation to sex: a nationwide registry-based study","volume":"85","author":"Wissenberg","year":"2014","journal-title":"Resuscitation"},{"key":"2020080405004377600_euaa124-B13","doi-asserted-by":"crossref","first-page":"e000112","DOI":"10.1136\/openhrt-2014-000112","article-title":"Genetic, clinical and pharmacological determinants of out-of-hospital cardiac arrest: rationale and outline of the AmsteRdam Resuscitation Studies (ARREST) registry","volume":"1","author":"Blom","year":"2014","journal-title":"Open Heart"},{"key":"2020080405004377600_euaa124-B14","doi-asserted-by":"crossref","DOI":"10.1093\/ehjcvp\/pvz038","article-title":"Differential effects on out-of-hospital cardiac arrest of dihydropyridines: real-world data from population-based cohorts across two European countries","author":"Eroglu","year":"2019","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"2020080405004377600_euaa124-B15","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.resuscitation.2011.09.026","article-title":"Beta-blockade causes a reduction in the frequency spectrum of VF but improves resuscitation outcome: a potential limitation of quantitative waveform measures","volume":"83","author":"Sherman","year":"2012","journal-title":"Resuscitation"},{"key":"2020080405004377600_euaa124-B16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pcad.2004.04.004","article-title":"Cardiovascular drug class specificity: beta-blockers","volume":"47","author":"Reiter","year":"2004","journal-title":"Prog Cardiovasc Dis"},{"key":"2020080405004377600_euaa124-B17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2174\/1573402114666180918102735","article-title":"Three generations of \u03b2-blockers: history, class differences and clinical applicability","volume":"15","author":"do Vale","year":"2019","journal-title":"Curr Hypertens Rev"},{"key":"2020080405004377600_euaa124-B18","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.resuscitation.2018.07.018","article-title":"Severity of ischemic heart disease and presenting rhythm in patients with out-of-hospital cardiac arrest","volume":"130","author":"Granfeldt","year":"2018","journal-title":"Resuscitation"},{"key":"2020080405004377600_euaa124-B19","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.resuscitation.2012.01.025","article-title":"Use of beta-blockers for the treatment of cardiac arrest due to ventricular fibrillation\/pulseless ventricular tachycardia: a systematic review","volume":"83","author":"de Oliveira","year":"2012","journal-title":"Resuscitation"},{"key":"2020080405004377600_euaa124-B20","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/0002-9149(83)90368-5","article-title":"Comparative effects of beta-adrenergic blocking drugs on experimental ventricular fibrillation threshold","volume":"51","author":"Anderson","year":"1983","journal-title":"Am J Cardiol"}],"container-title":["EP Europace"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/europace\/article-pdf\/22\/8\/1206\/33561080\/euaa124.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/europace\/article-pdf\/22\/8\/1206\/33561080\/euaa124.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T09:11:23Z","timestamp":1596532283000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/22\/8\/1206\/5864437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,28]]},"references-count":20,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,6,28]]},"published-print":{"date-parts":[[2020,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euaa124","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,8]]},"published":{"date-parts":[[2020,6,28]]}}}