{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:29:39Z","timestamp":1740126579140,"version":"3.37.3"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Minister of Science and Higher Education called \u2018Regional Initiative of Excellence\u2019","award":["024\/RID\/2018\/19"],"award-info":[{"award-number":["024\/RID\/2018\/19"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Soluble suppression of tumourigenicity 2 (sST2) and galectin-3 are involved in cardiac fibrosis, inflammation, and remodelling. However, the place of sST2 and galectin-3 in predicting the outcomes of electrical cardioversion of atrial fibrillation (AF) is uncertain. We evaluated whether these biomarkers could predict sinus rhythm (SR) maintenance after cardioversion of persistent AF in patients with normal left ventricular systolic function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The study included 80 patients with persistent AF, who underwent cardioversion from February 2016 to August 2018. The blood concentrations of sST-2 and galectin-3 were measured with ELISA and the ASPECT-PLUS assays. Clinical and electrocardiographic follow-up was performed at months 1, 6, and 12. Patients who maintained SR at 12\u2009months had significantly lower concentrations of sST2, measured by ELISA and ASPECT-PLUS assays, than the remaining patients (16.9\u2009\u00b1\u20099.8 vs. 28\u2009\u00b1\u200922.9\u2009ng\/mL; P\u2009&amp;lt;\u20090.001; 28.7\u2009\u00b1\u200913.4 vs. 40\u2009\u00b1\u200925.1\u2009ng\/mL; P\u2009=\u20090.003); the concentration of galectin-3 did not differ between these patients. Multivariable logistic regression showed that log-transformed sST2 ELISA was a significant predictor of SR maintenance at 12\u2009months [odds ratio 0.14; 95% confidence interval (CI) 0.03\u20130.58; P\u2009=\u20090.006]. On receiver-operating characteristic curve analysis, the areas under the curve for the concentration of sST2 was 0.752 (95% CI 0.634\u20130.870; P\u2009&amp;lt;\u20090.001). The concentrations of sST2 measured with the two assays were strongly correlated (rho\u2009=\u20090.8; CI 95% 0.7\u20130.87; P\u2009=\u20090.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Soluble suppression of tumourigenicity 2, but not galectin-3, can be used to predict SR maintenance after cardioversion of AF in patients with normal left ventricular systolic function. The measurements of sST2 concentrations with the rapid lateral flow and enzyme-linked immunoassays were consistent.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaa135","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T19:13:07Z","timestamp":1588619587000},"page":"1470-1479","source":"Crossref","is-referenced-by-count":8,"title":["The prognostic value of soluble suppression of tumourigenicity 2 and galectin-3 for sinus rhythm maintenance after cardioversion due to persistent atrial fibrillation in patients with normal left ventricular systolic function"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0632-6573","authenticated-orcid":false,"given":"Pawe\u0142","family":"Wa\u0142ek","sequence":"first","affiliation":[{"name":"1st Clinic of Cardiology and Electrotherapy, Voivodship Hospital Kielce, Grunwaldzka\u00a045, 25-736 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Gorczyca","sequence":"additional","affiliation":[{"name":"1st Clinic of Cardiology and Electrotherapy, Voivodship Hospital Kielce, Grunwaldzka\u00a045, 25-736 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urszula","family":"Grabowska","sequence":"additional","affiliation":[{"name":"Medical Laboratory, Voivodship Hospital Kielce, Grunwaldzka\u00a045, 25-736 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Spa\u0142ek","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Collegium Medicum, Jan Kochanowski University, 19 IX Wiek\u00f3w Kielc, 25-317 Kielce, Poland"},{"name":"Department of Diagnostic Imaging, Holy Cross Center of Oncology, Stefana Artwi\u0144skiego 3, 25-734 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Wo\u017cakowska-Kap\u0142on","sequence":"additional","affiliation":[{"name":"1st Clinic of Cardiology and Electrotherapy, Voivodship Hospital Kielce, Grunwaldzka\u00a045, 25-736 Kielce, Poland"},{"name":"Collegium Medicum, Jan Kochanowski University, 19 IX Wiek\u00f3w Kielc Street, 25-317 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,8,5]]},"reference":[{"key":"2020112312164501100_euaa135-B1","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1161\/CIRCULATIONAHA.111.039677","article-title":"Atrial fibrillation: current knowledge and future directions in epidemiology and genomics","volume":"124","author":"Magnani","year":"2011","journal-title":"Circulation"},{"key":"2020112312164501100_euaa135-B2","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1093\/europace\/euw295","article-title":"2016 ESC 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