{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T10:23:36Z","timestamp":1769509416021,"version":"3.49.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":92,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010447","name":"German Centre for Cardiovascular Research","doi-asserted-by":"publisher","award":["FKZ 81Z2710104"],"award-info":[{"award-number":["FKZ 81Z2710104"]}],"id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"German Centre for Cardiovascular Research","doi-asserted-by":"publisher","award":["81Z0710112"],"award-info":[{"award-number":["81Z0710112"]}],"id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>S100B, a well-known damage-associated molecular pattern protein is released acutely by central and peripheral nerves and upon concomitant denervation in pulmonary vein isolation (PVI). We aimed to investigate whether the ablation technique used for PVI impacts S100B release in patients with paroxysmal atrial fibrillation (AF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The study population consisted of 73 consecutive patients (age: 62.7\u2009\u00b1\u200910.9\u2009years, 54.8% males) undergoing first-time PVI with either radiofrequency (RF; n\u2009=\u200930) or cryoballoon (CB; n\u2009=\u200943) for paroxysmal AF. S100B determined from venous plasma samples taken immediately before and after PVI increased from 33.5\u2009\u00b1\u20091.8 to 91.1\u2009\u00b1\u20095.3\u2009pg\/mL (P\u2009&amp;lt;\u20090.0001). S100B release in patients undergoing CB-PVI was 3.9 times higher compared to patients with RF-PVI (\u0394S100B: 21.1\u2009\u00b1\u20092.7 vs. 83.1\u2009\u00b1\u20095.2\u2009 pg\/mL, P\u2009&amp;lt;\u20090.0001). During a mean follow-up of 314\u2009\u00b1\u2009186\u2009days, AF recurrences were observed in 18\/71 (25.4%) patients (RF-PVI: n\u2009=\u20099\/28, CB-PVI: n\u2009=\u20099\/43). Univariate Cox regression analysis indicated that an increase in S100B was associated with higher freedom from AF in follow-up (hazard ratio per 10\u2009 pg\/mL release of S100B: 0.83; 95% confidence interval: 0.72\u20130.95; P\u2009=\u20090.007).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The ablation technique used for PVI has an impact on the release of S100B, a well-established biomarker for neural damage.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaa159","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T19:12:50Z","timestamp":1596222770000},"page":"1502-1508","source":"Crossref","is-referenced-by-count":15,"title":["Impact of the ablation technique on release of the neuronal injury marker S100B during pulmonary vein isolation"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3237-140X","authenticated-orcid":false,"given":"Katharina","family":"Scherschel","sequence":"first","affiliation":[{"name":"Division of Cardiology, cardiac Neuro- and Electrophysiology Research Consortium (cNEP), EVK D\u00fcsseldorf, Kirchfeldstrasse 40, 40217 D\u00fcsseldorf, Germany"},{"name":"Clinic for Cardiology, University Heart & Vascular Centre, University Hospital Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg\/Kiel\/L\u00fcbeck, Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Hedenus","sequence":"additional","affiliation":[{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg\/Kiel\/L\u00fcbeck, Hamburg Germany"},{"name":"Department of Cardiology, Asklepios Klinik St. Georg, Lohm\u00fchlenstr. 5, 20099 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Jungen","sequence":"additional","affiliation":[{"name":"Clinic for Cardiology, University Heart & Vascular Centre, University Hospital Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg\/Kiel\/L\u00fcbeck, Hamburg Germany"},{"name":"Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"M\u00fcnkler","sequence":"additional","affiliation":[{"name":"Clinic for Cardiology, University Heart & Vascular Centre, University Hospital Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg\/Kiel\/L\u00fcbeck, Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Willems","sequence":"additional","affiliation":[{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg\/Kiel\/L\u00fcbeck, Hamburg Germany"},{"name":"Department of Cardiology, Asklepios Klinik St. Georg, Lohm\u00fchlenstr. 5, 20099 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Anwar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Asklepios Klinik St. Georg, Lohm\u00fchlenstr. 5, 20099 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas","family":"Klatt","sequence":"additional","affiliation":[{"name":"Clinic for Cardiology, University Heart & Vascular Centre, University Hospital Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg\/Kiel\/L\u00fcbeck, Hamburg 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Hamburg Germany"},{"name":"Institute of Neural and Sensory Physiology, Medical Faculty, Heinrich Heine University D\u00fcsseldorf, Universit\u00e4tsstrasse 1, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,8,23]]},"reference":[{"key":"2020112312165468800_euaa159-B1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1741-7015-11-50","article-title":"Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults: an evidence and consensus-based update","volume":"11","author":"Und\u00e9n","year":"2013","journal-title":"BMC Med"},{"key":"2020112312165468800_euaa159-B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scitranslmed.aav7770","article-title":"Cardiac glial cells release neurotrophic S100B upon catheter-based treatment of atrial fibrillation","volume":"11","author":"Scherschel","year":"2019","journal-title":"Sci Transl 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