{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:29:44Z","timestamp":1740126584606,"version":"3.37.3"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T00:00:00Z","timestamp":1598140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Bushell Travelling Fellowship"},{"DOI":"10.13039\/501100001232","name":"Royal Australasian College of Physicians","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims\u2003<\/jats:title>\n                  <jats:p>Catheter ablation is an effective treatment for post-infarction ventricular tachycardia (VT). However, some patients may experience a worsened arrhythmia phenotype after ablation. We aimed to determine the prevalence and prognostic impact of arrhythmia exacerbation (AE) after post-infarction VT ablation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results\u2003<\/jats:title>\n                  <jats:p>A total of 1187 consecutive patients (93% men, median age 68\u2009years, median ejection fraction 30%) who underwent post-infarction VT ablation at six centres were included. Arrhythmia exacerbation was defined as post-ablation VT storm or incessant VT in patients without prior similar events. During follow-up (median 717\u2009days), 426 (36%) patients experienced VT recurrence. Events qualifying as AE occurred in 67 patients (6%). Median times to VT recurrence with and without AE were 238 [interquartile range (IQR) 35\u2013640] days and 135 (IQR 22\u2013521) days, respectively (P\u2009=\u20090.25). Almost half of the patients (46%) who experienced AE experienced it within 6\u2009months of the index procedure. Patients with AE had had longer ablation times during the ablation procedures compared to the rest of the patients (median 42 vs. 34\u2009min, P\u2009=\u20090.02). Among patients with VT recurrence, the risk of death or heart transplantation was significantly higher in patients with than without AE (hazard ratio 1.99, 95% CI 1.28\u20133.10; P\u2009=\u20090.002) after adjusting for age, gender, ejection fraction, cardiac resynchronization therapy, post-ablation non-inducibility, and post-ablation amiodarone use.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion\u2003<\/jats:title>\n                  <jats:p>Arrhythmia exacerbation after ablation of infarct-related VT is infrequent but is independently associated with an adverse long-term outcome among patients who experience a VT recurrence. The mechanisms and mitigation strategies of AE after catheter ablation require further investigation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaa169","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T19:10:00Z","timestamp":1596913800000},"page":"1680-1687","source":"Crossref","is-referenced-by-count":3,"title":["Arrhythmia exacerbation after post-infarction ventricular tachycardia ablation: prevalence and prognostic significance"],"prefix":"10.1093","volume":"22","author":[{"given":"Konstantinos C","family":"Siontis","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyungjin M","family":"Kim","sequence":"additional","affiliation":[{"name":"Biostatistics Department, School of Public Health, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Vergara","sequence":"additional","affiliation":[{"name":"Department of Arrhythmology, San Raffaele University Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Peretto","sequence":"additional","affiliation":[{"name":"Department of Arrhythmology, San Raffaele University Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duc H","family":"Do","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center, University of California-Los Angeles, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"de Riva","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Cardiac Pacing and Electrophysiology, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux, Pessac, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Qian","sequence":"additional","affiliation":[{"name":"Arrhythmia Service, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Yokokawa","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Michigan, 1500 East Medical Center Drive SPC 5853, Ann Arbor, MI 48109-5853, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krit","family":"Jongnarangsin","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Michigan, 1500 East Medical Center Drive SPC 5853, Ann Arbor, MI 48109-5853, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Latchamsetty","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Michigan, 1500 East Medical Center Drive SPC 5853, Ann Arbor, MI 48109-5853, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Jais","sequence":"additional","affiliation":[{"name":"Department of Cardiac Pacing and Electrophysiology, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux, Pessac, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Sacher","sequence":"additional","affiliation":[{"name":"Department of Cardiac Pacing and Electrophysiology, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux, Pessac, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usha","family":"Tedrow","sequence":"additional","affiliation":[{"name":"Arrhythmia Service, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalyanam","family":"Shivkumar","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center, University of California-Los Angeles, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Zeppenfeld","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Della Bella","sequence":"additional","affiliation":[{"name":"Department of Arrhythmology, San Raffaele University Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William 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