{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:19:32Z","timestamp":1761581972587,"version":"3.37.3"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T00:00:00Z","timestamp":1602288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims\u2003<\/jats:title>\n                  <jats:p>To evaluate the risk of syncopal recurrences after pacemaker implantation in a population of patients with syncope of suspected bradyarrhythmic aetiology.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results\u2003<\/jats:title>\n                  <jats:p>Prospective, multicentre, observational registry enrolling 1364 consecutive patients undergoing pacemaker implantation for syncope of bradyarrhythmic aetiology (proven or presumed). Before pacemaker implantation, all patients underwent a cardiac work-up in order to establish the bradyarrhythmic aetiology of syncope. According to the results of the diagnostic work-up, patients were divided into three groups: Group A, patients in whom a syncope-electrocardiogram (ECG) correlation was established (n\u2009=\u2009329, 24.1%); Group B, those in whom clinically significant bradyarrhythmias were detected without a documented syncope-ECG correlation (n\u2009=\u2009877, 64.3%); and Group C, those in whom bradyarrhythmias were not detected and the bradyarrhythmic origin of syncope remained presumptive (n\u2009=\u2009158, 11.6%). During a median follow-up of 50\u2009months, 213 patients (15.6%) reported at least one syncopal recurrence. Patients in Groups B and C showed a significantly higher risk of syncopal recurrences than those in Group A [hazard ratios (HRs): 1.60 and 2.66, respectively, P\u2009&amp;lt;\u20090.05]. Failure to establish a syncope-ECG correlation during diagnostic work-up before pacemaker implantation was an independent predictor of syncopal recurrence on multivariate analysis (HR: 1.90; P\u2009=\u20090.002).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In selecting patients with syncope of suspected bradyarrhythmic aetiology for pacemaker implantation, establishing a correlation between syncope and bradyarrhythmias maximizes the efficacy of pacing and reduces the risk of syncopal recurrences.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaa188","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T11:38:35Z","timestamp":1591961915000},"page":"1729-1736","source":"Crossref","is-referenced-by-count":10,"title":["Risk of syncopal recurrences in patients treated with permanent pacing for bradyarrhythmic syncope: role of correlation between symptoms and electrocardiogram findings"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6705-6218","authenticated-orcid":false,"given":"Pietro","family":"Palmisano","sequence":"first","affiliation":[{"name":"Cardiology Unit, \u201cCard. 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Panico\u201d Hospital, Tricase, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Luigi","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Cardiology Department, Policlinico Riuniti University Hospital, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Ammendola","sequence":"additional","affiliation":[{"name":"Dipartimento di Cardiologia, Universit\u00e0 della Campania - L.Vanvitelli, Ospedale Monaldi, Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Ziacchi","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, University of Bologna, S.Orsola-Malpighi University Hospital, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Guerra","sequence":"additional","affiliation":[{"name":"Cardiology and Arrhythmology Clinic, Marche Polytechnic University, University Hospital \u201cUmberto I\u2014Lancisi\u2014Salesi\u201d, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Aspromonte","sequence":"additional","affiliation":[{"name":"Cardiology - Coronary Care Unit, Pugliese-Ciaccio Hospital, Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Laffi","sequence":"additional","affiliation":[{"name":"Cardiology Division, Villa Scassi Hospital, Genova, ASL 3, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Pimpini","sequence":"additional","affiliation":[{"name":"Unit of Cardiology-CCU, Italian National Reserch Centre on Aging, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bonomo Hospital, Andria, Italy"},{"name":"Department of Medical and Surgery Sciences, University of Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Boggio","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Azienda Ospedaliera Universitaria \u201cMaggiore della Carit\u00e0\u201d, Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Guido","sequence":"additional","affiliation":[{"name":"Cardiology Unit, \u201cCard. G. Panico\u201d Hospital, Tricase, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Patti","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Azienda Ospedaliera Universitaria \u201cMaggiore della Carit\u00e0\u201d, Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natale Daniele","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgery Sciences, University of Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Nigro","sequence":"additional","affiliation":[{"name":"Dipartimento di Cardiologia, Universit\u00e0 della Campania - L.Vanvitelli, Ospedale Monaldi, Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Biffi","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, University of Bologna, S.Orsola-Malpighi University Hospital, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Dello Russo","sequence":"additional","affiliation":[{"name":"Cardiology and Arrhythmology Clinic, Marche Polytechnic University, University Hospital \u201cUmberto I\u2014Lancisi\u2014Salesi\u201d, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germano","family":"Gaggioli","sequence":"additional","affiliation":[{"name":"Cardiology Division, Villa Scassi Hospital, Genova, ASL 3, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Accogli","sequence":"additional","affiliation":[{"name":"Cardiology Unit, \u201cCard. 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