{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T19:48:56Z","timestamp":1785354536745,"version":"3.55.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"NHMRC CRE"},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R250-2017\u2013134"],"award-info":[{"award-number":["R250-2017\u2013134"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R324-2019\u20131933"],"award-info":[{"award-number":["R324-2019\u20131933"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Leducq Foundation for Cardiovascular Research","award":["18CVD05"],"award-info":[{"award-number":["18CVD05"]}]},{"name":"Towards Precision Medicine with Human iPSCs for Cardiac Channelopathies"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>In 2003, an Australian woman was convicted by a jury of smothering and killing her four children over a 10-year period. Each child died suddenly and unexpectedly during a sleep period, at ages ranging from 19\u2009days to 18\u2009months. In 2019 we were asked to investigate if a genetic cause could explain the children\u2019s deaths as part of an inquiry into the mother\u2019s convictions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Whole genomes or exomes of the mother and her four children were sequenced. Functional analysis of a novel CALM2 variant was performed by measuring Ca2+-binding affinity, interaction with calcium channels and channel function. We found two children had a novel calmodulin variant (CALM2 G114R) that was inherited maternally. Three genes (CALM1-3) encode identical calmodulin proteins. A variant in the corresponding residue of CALM3 (G114W) was recently reported in a child who died suddenly at age 4 and a sibling who suffered a cardiac arrest at age 5. We show that CALM2 G114R impairs calmodulin's ability to bind calcium and regulate two pivotal calcium channels (CaV1.2 and RyR2) involved in cardiac excitation contraction coupling. The deleterious effects of G114R are similar to those produced by G114W and N98S, which are considered arrhythmogenic and cause sudden cardiac death in children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A novel functional calmodulin variant (G114R) predicted to cause idiopathic ventricular fibrillation, catecholaminergic polymorphic ventricular tachycardia, or mild long QT syndrome was present in two children. A fatal arrhythmic event may have been triggered by their intercurrent infections. Thus, calmodulinopathy emerges as a reasonable explanation for a natural cause of their deaths.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaa272","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T19:28:49Z","timestamp":1597260529000},"page":"441-450","source":"Crossref","is-referenced-by-count":40,"title":["Infanticide vs. inherited cardiac arrhythmias"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9247-8551","authenticated-orcid":false,"given":"Malene","family":"Brohus","sequence":"first","affiliation":[{"name":"Department of Chemistry and Bioscience, Aalborg University, Fredrik Bajers Vej 7H, 9220 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todor","family":"Arsov","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Disease, Centre for Personalised Immunology, John Curtin School of Medical Research, Australian National University, 131 Garran Road, Canberra, Acton 2601, Australia"},{"name":"Department of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Disease, Centre for Personalised Immunology, John Curtin School of Medical Research, Australian National University, 131 Garran Road, Canberra, Acton 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8426-9802","authenticated-orcid":false,"given":"Helene Halkj\u00e6r","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Bioscience, Aalborg University, Fredrik Bajers Vej 7H, 9220 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4973-8543","authenticated-orcid":false,"given":"Mette","family":"Nyegaard","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8739-6527","authenticated-orcid":false,"given":"Lia","family":"Crotti","sequence":"additional","affiliation":[{"name":"Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin, Via Pier Lombardo, 22, 20135 Milan, Italy"},{"name":"Department of Cardiovascular, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, San Luca Hospital, Milan, Italy"},{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Adamski","sequence":"additional","affiliation":[{"name":"Biology Teaching and Learning Centre, Research School of Biology and John Curtin School of Medical Research, The Australian National University, Canberra, Acton 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Zhang","sequence":"additional","affiliation":[{"name":"NGS Team, Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Canberra, Acton 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0788-6513","authenticated-orcid":false,"given":"Matt A","family":"Field","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Disease, Centre for Personalised Immunology, John Curtin School of Medical Research, Australian National University, 131 Garran Road, Canberra, Acton 2601, Australia"},{"name":"Centre for Tropical Bioinformatics and Molecular Biology, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland 4878, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5764-5948","authenticated-orcid":false,"given":"Vicki","family":"Athanasopoulos","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Disease, Centre for Personalised Immunology, John Curtin School of Medical Research, Australian National University, 131 Garran Road, Canberra, Acton 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4850-4171","authenticated-orcid":false,"given":"Isabelle","family":"Bar\u00f3","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Nantes, CNRS, INSERM, L\u2019institut du Thorax, F-44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2269-5750","authenticated-orcid":false,"given":"B\u00e1rbara B","family":"Ribeiro de Oliveira-Mendes","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Nantes, CNRS, INSERM, L\u2019institut du Thorax, F-44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7751-2280","authenticated-orcid":false,"given":"Richard","family":"Redon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Nantes, CNRS, INSERM, L\u2019institut du Thorax, F-44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5057-0998","authenticated-orcid":false,"given":"Flavien","family":"Charpentier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Nantes, CNRS, INSERM, L\u2019institut du Thorax, F-44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0000-7520","authenticated-orcid":false,"given":"Hariharan","family":"Raju","sequence":"additional","affiliation":[{"name":"Cardiology Department, Faculty of Medicine, Macquarie University, Sydney, New South Wales 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"DiSilvestre","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta T2N 4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiwu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta T2N 4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8954-4930","authenticated-orcid":false,"given":"Haloom","family":"Rafehi","sequence":"additional","affiliation":[{"name":"Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Royal Parade, Parkville, Victoria 3052, Australia"},{"name":"Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6576-5862","authenticated-orcid":false,"given":"Antony","family":"Kaspi","sequence":"additional","affiliation":[{"name":"Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Royal Parade, Parkville, Victoria 3052, Australia"},{"name":"Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5132-0774","authenticated-orcid":false,"given":"Melanie","family":"Bahlo","sequence":"additional","affiliation":[{"name":"Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Royal Parade, Parkville, Victoria 3052, Australia"},{"name":"Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7253-6846","authenticated-orcid":false,"given":"Ivy E","family":"Dick","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sui Rong Wayne","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta T2N 4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3331-9363","authenticated-orcid":false,"given":"Matthew C","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Disease, Centre for Personalised Immunology, John Curtin School of Medical Research, Australian National University, 131 Garran Road, Canberra, Acton 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9799-0298","authenticated-orcid":false,"given":"Carola G","family":"Vinuesa","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Disease, Centre for Personalised Immunology, John Curtin School of Medical Research, Australian National University, 131 Garran Road, Canberra, Acton 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1423-2481","authenticated-orcid":false,"given":"Michael Toft","family":"Overgaard","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Bioscience, Aalborg University, Fredrik Bajers Vej 7H, 9220 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0367-1048","authenticated-orcid":false,"given":"Peter J","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin, Via Pier Lombardo, 22, 20135 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"2021031520092788100_euaa272-B1","first-page":"207","author":"Meadow","year":"1997","edition":"3rd ed."},{"key":"2021031520092788100_euaa272-B2","year":"2003"},{"key":"2021031520092788100_euaa272-B3","year":"2004"},{"key":"2021031520092788100_euaa272-B4"},{"key":"2021031520092788100_euaa272-B5","year":"2019"},{"key":"2021031520092788100_euaa272-B6"},{"key":"2021031520092788100_euaa272-B7"},{"key":"2021031520092788100_euaa272-B8","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41572-020-0188-7","article-title":"Inherited cardiac arrhythmias","volume":"6","author":"Schwartz","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"2021031520092788100_euaa272-B9","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1093\/eurheartj\/ehz311","article-title":"Calmodulin mutations and life-threatening cardiac arrhythmias: insights from the International Calmodulinopathy Registry","volume":"40","author":"Crotti","year":"2019","journal-title":"Eur Heart J"},{"key":"2021031520092788100_euaa272-B10","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.ajhg.2012.08.015","article-title":"Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death","volume":"91","author":"Nyegaard","year":"2012","journal-title":"Am J Hum Genet"},{"key":"2021031520092788100_euaa272-B11","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1161\/CIRCULATIONAHA.112.001216","article-title":"Calmodulin mutations associated with recurrent cardiac arrest in infants","volume":"127","author":"Crotti","year":"2013","journal-title":"Circulation"},{"key":"2021031520092788100_euaa272-B12","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1113\/JP279307","article-title":"Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca(2+) binding and cause misfolding","volume":"598","author":"Wang","year":"2020","journal-title":"J Physiol"},{"key":"2021031520092788100_euaa272-B13","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/febs.13184","article-title":"Calmodulin mutations causing catecholaminergic polymorphic ventricular tachycardia confer opposing functional and biophysical molecular changes","volume":"282","author":"S\u00f8ndergaard","year":"2015","journal-title":"FEBS J"},{"key":"2021031520092788100_euaa272-B14","doi-asserted-by":"crossref","first-page":"26151","DOI":"10.1074\/jbc.M115.676627","article-title":"Arrhythmogenic calmodulin mutations affect the activation and termination of cardiac ryanodine receptor-mediated Ca2+ release","volume":"290","author":"S\u00f8ndergaard","year":"2015","journal-title":"J Biol Chem"},{"key":"2021031520092788100_euaa272-B15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.yjmcc.2014.04.022","article-title":"Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca(2+) currents and promote proarrhythmic behavior in ventricular myocytes","volume":"74","author":"Limpitikul","year":"2014","journal-title":"J Mol Cell Cardiol"},{"key":"2021031520092788100_euaa272-B16","doi-asserted-by":"crossref","first-page":"10370","DOI":"10.1038\/ncomms10370","article-title":"Arrhythmogenesis in Timothy syndrome is associated with defects in Ca(2+)-dependent inactivation","volume":"7","author":"Dick","year":"2016","journal-title":"Nat Commun"},{"key":"2021031520092788100_euaa272-B17","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1042\/BJ20071287","article-title":"Endoplasmic reticulum Ca2+ measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+ release","volume":"412","author":"Jones","year":"2008","journal-title":"Biochem J"},{"key":"2021031520092788100_euaa272-B18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.immuni.2007.01.010","article-title":"Regulation of signal transducer and activator of transcription signaling by the tyrosine phosphatase PTP-BL","volume":"26","author":"Nakahira","year":"2007","journal-title":"Immunity"},{"key":"2021031520092788100_euaa272-B19","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.immuni.2012.08.027","article-title":"NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells","volume":"37","author":"Masters","year":"2012","journal-title":"Immunity"},{"key":"2021031520092788100_euaa272-B20","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.003122","article-title":"Dysfunction of the voltage-gated K+ channel \u03b22 subunit in a familial case of Brugada syndrome","volume":"5","author":"Portero","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"2021031520092788100_euaa272-B21","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0896-6273(03)00086-2","article-title":"The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina","volume":"37","author":"Dick","year":"2003","journal-title":"Neuron"},{"key":"2021031520092788100_euaa272-B22","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0896-6273(03)00088-6","article-title":"Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon","volume":"37","author":"Altrock","year":"2003","journal-title":"Neuron"},{"key":"2021031520092788100_euaa272-B23","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/s41598-018-19198-0","article-title":"Mutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy-like syndrome","volume":"8","author":"Yabe","year":"2018","journal-title":"Sci Rep"},{"key":"2021031520092788100_euaa272-B24","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41467-019-14079-0","article-title":"The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly","volume":"11","author":"Pinese","year":"2020","journal-title":"Nat Commun"},{"key":"2021031520092788100_euaa272-B25","first-page":"1030","article-title":"MetaDome: pathogenicity analysis of genetic variants through aggregation of homologous human protein domains","volume":"40","author":"Wiel","year":"2019","journal-title":"Hum Mutat"},{"key":"2021031520092788100_euaa272-B26","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"2021031520092788100_euaa272-B27","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3389\/fnmol.2018.00396","article-title":"Human calmodulin mutations","volume":"11","author":"Jensen","year":"2018","journal-title":"Front Mol Neurosci"},{"key":"2021031520092788100_euaa272-B28","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1111\/febs.12337","article-title":"Calmodulin in a heartbeat","volume":"280","author":"Sorensen","year":"2013","journal-title":"FEBS J"},{"key":"2021031520092788100_euaa272-B29","doi-asserted-by":"crossref","first-page":"4554","DOI":"10.1111\/febs.14969","article-title":"Diminished inhibition and facilitated activation of RyR2-mediated Ca(2+) release is a common defect of arrhythmogenic calmodulin mutations","volume":"286","author":"S\u00f8ndergaard","year":"2019","journal-title":"FEBS J"},{"key":"2021031520092788100_euaa272-B30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2012.08.005","article-title":"Determinants of incomplete penetrance and variable expressivity in heritable cardiac arrhythmia syndromes","volume":"161","author":"Giudicessi","year":"2013","journal-title":"Transl Res"},{"key":"2021031520092788100_euaa272-B31","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1093\/eurheartj\/ehz463","article-title":"The International Calmodulinopathy Registry: recording the diverse phenotypic spectrum of un-CALM hearts","volume":"40","author":"Nyegaard","year":"2019","journal-title":"Eur Heart J"},{"key":"2021031520092788100_euaa272-B32","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jacc.2013.07.091","article-title":"A mutation in CALM1 encoding calmodulin in familial idiopathic ventricular fibrillation in childhood and adolescence","volume":"63","author":"Marsman","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2021031520092788100_euaa272-B33","first-page":"3925","article-title":"Modifier genes for sudden cardiac death","volume":"39","author":"Schwartz","year":"2018","journal-title":"Eur Heart J"},{"key":"2021031520092788100_euaa272-B34","article-title":"MTMR4 SNVs modulate ion channel degradation and clinical severity in congenital long QT syndrome: insights in the mechanism of action of protective modifier genes","author":"Lee","year":"2020","journal-title":"Cardiovasc Res"},{"key":"2021031520092788100_euaa272-B35","first-page":"139","article-title":"May fever trigger ventricular fibrillation?","volume":"5","author":"Pasqui\u00e9","year":"2005","journal-title":"Indian Pacing Electrophysiol J"},{"key":"2021031520092788100_euaa272-B36","doi-asserted-by":"crossref","first-page":"693","DOI":"10.2170\/jjphysiol.44.693","article-title":"Changes in plasma catecholamines during fever induced by bacterial endotoxin and interleukin-1 beta","volume":"44","author":"Sakata","year":"1994","journal-title":"JJP"},{"key":"2021031520092788100_euaa272-B37","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/00024382-199510000-00007","article-title":"Sustained elevation in circulating catecholamine levels during polymicrobial sepsis","volume":"4","author":"Hahn","year":"1995","journal-title":"Shock"},{"key":"2021031520092788100_euaa272-B38","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41569-019-0266-2","article-title":"Epidemiology of inherited arrhythmias","volume":"17","author":"Offerhaus","year":"2020","journal-title":"Nature Reviews Cardiology"},{"key":"2021031520092788100_euaa272-B39","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3389\/fphys.2016.00308","article-title":"What Is the Arrhythmic Substrate in Viral Myocarditis? Insights from Clinical and Animal Studies","volume":"7","author":"Tse","year":"2016","journal-title":"Front Physiol"}],"container-title":["EP Europace"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/europace\/article-pdf\/23\/3\/441\/36603876\/euaa272.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/europace\/article-pdf\/23\/3\/441\/36603876\/euaa272.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T20:10:09Z","timestamp":1615839009000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/23\/3\/441\/5983835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,17]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,11,17]]},"published-print":{"date-parts":[[2021,3,8]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euaa272","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,3,1]]},"published":{"date-parts":[[2020,11,17]]}}}