{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:12:44Z","timestamp":1777918364344,"version":"3.51.4"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T00:00:00Z","timestamp":1601596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"EORP"},{"name":"Abbott Vascular Int."},{"name":"Amgen Cardiovascular"},{"name":"AstraZeneca"},{"name":"Bayer"},{"name":"Boehringer Ingelheim"},{"name":"Boston Scientific"},{"name":"The Bristol Myers Squibb and Pfizer Alliance"},{"name":"The Alliance Daiichi Sankyo Europe GmbH"},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006520","name":"Edwards","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Gedeon Richter Plc."},{"name":"Menarini Int. Op."},{"name":"MSD-Merck & Co."},{"name":"Novartis Pharma AG"},{"name":"ResMed"},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011725","name":"SERVIER","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Vifor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>There has been an increasing focus on integrated, multidisciplinary, and holistic care in the treatment of atrial fibrillation (AF). The \u2018Atrial Fibrillation Better Care\u2019 (ABC) pathway has been proposed to streamline integrated care in AF. We evaluated the impact on outcomes of an ABC adherent management in a contemporary real-life European-wide AF cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Patients enrolled in the ESC-EHRA EURObservational Research Programme in AF General Long-Term Registry with baseline data to evaluate ABC criteria and available follow-up data were considered for this analysis. Among the original 11\u2009096 AF patients enrolled, 6646 (59.9%) were included in this analysis, of which 1996 (30.0%) managed as ABC adherent. Patients adherent to ABC care had lower CHA2DS2-VASc and HAS-BLED scores (mean \u00b1 SD, 2.68\u2009\u00b1\u20091.57 vs. 3.07\u2009\u00b1\u20091.90 and 1.26\u2009\u00b1\u20090.93 vs. 1.58\u2009\u00b1\u20091.12, respectively; P\u2009&amp;lt;\u20090.001). At 1-year follow-up, patients managed adherent to ABC pathway compared to non-adherent ones had a lower rate of any thromboembolic event (TE)\/acute coronary syndrome (ACS)\/cardiovascular (CV) death (3.8% vs. 7.6%), CV death (1.9% vs. 4.8%), and all-cause death (3.0% vs. 6.4%) (all P\u2009&amp;lt;\u20090.0001). On Cox multivariable regression analysis, ABC adherent care showed an association with a lower risk of any TE\/ACS\/CV death [hazard ratio (HR): 0.59, 95% confidence interval (CI): 0.44\u20130.79], CV death (HR: 0.52, 95% CI: 0.35\u20130.78), and all-cause death (HR: 0.57, 95% CI: 0.43\u20130.78).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In a large contemporary cohort of European AF patients, a clinical management adherent to ABC pathway for integrated care is associated with a significant lower risk for cardiovascular events, CV death, and all-cause death.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaa274","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T19:12:22Z","timestamp":1601061142000},"page":"174-183","source":"Crossref","is-referenced-by-count":101,"title":["Relation of outcomes to ABC (Atrial Fibrillation Better Care) pathway adherent care in European patients with atrial fibrillation: an analysis from the ESC-EHRA EORP Atrial Fibrillation General Long-Term (AFGen LT) Registry"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1452-2478","authenticated-orcid":false,"given":"Marco","family":"Proietti","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Community Health, University of Milan, Via della Commenda 19, 20122, Milan, Italy"},{"name":"Geriatric Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"},{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory Y H","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK"},{"name":"Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Laroche","sequence":"additional","affiliation":[{"name":"EURObservational Research Programme Department, European Society of Cardiology, Sophia Antipolis, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Fauchier","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, Centre Hospitalier Universitaire Trousseau, Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Marin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, IMIB-Arrixaca, University of Murcia, CIBER-CV, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Nabauer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ludwig-Maximilians-University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Potpara","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Belgrade, Belgrade, Serbia"},{"name":"Intensive Arrhythmia Care, Cardiology Clinic, Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gheorghe-Andrei","family":"Dan","sequence":"additional","affiliation":[{"name":"University of Medicine, \u2018Carol Davila\u2019, Colentina University Hospital, Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zbigniew","family":"Kalarus","sequence":"additional","affiliation":[{"name":"Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia, Katowice, Silesian Centre for Heart Diseases, Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Tavazzi","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo Pietro","family":"Maggioni","sequence":"additional","affiliation":[{"name":"EURObservational Research Programme Department, European Society of Cardiology, Sophia Antipolis, France"},{"name":"Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Boriani","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the ESC-EORP Atrial Fibrillation General Long-Term Registry Investigators Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,10,2]]},"reference":[{"key":"2021020808553751100_euaa274-B1","article-title":"2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS)","author":"Hindricks","year":"2020","journal-title":"Eur Heart J"},{"key":"2021020808553751100_euaa274-B2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/europace\/eux318","article-title":"Integrating new approaches to atrial fibrillation management: the 6th AFNET\/EHRA Consensus Conference","volume":"20","author":"Kotecha","year":"2018","journal-title":"Europace"},{"key":"2021020808553751100_euaa274-B3","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/S0140-6736(17)31072-3","article-title":"The future of atrial fibrillation management: integrated care and stratified therapy","volume":"390","author":"Kirchhof","year":"2017","journal-title":"Lancet"},{"key":"2021020808553751100_euaa274-B4","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002197","article-title":"Cause of death and predictors of all-cause mortality in anticoagulated patients with nonvalvular atrial fibrillation: data from ROCKET AF","volume":"5","author":"Pokorney","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"2021020808553751100_euaa274-B5","first-page":"722","article-title":"\u2018Real-world\u2019 atrial fibrillation management in Europe: observations from the 2-year follow-up of the EURObservational Research Programme-Atrial Fibrillation General Registry Pilot Phase","volume":"19","author":"Proietti","year":"2017","journal-title":"Europace"},{"key":"2021020808553751100_euaa274-B6","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1016\/j.jacc.2016.09.944","article-title":"Causes of death in anticoagulated patients with atrial fibrillation","volume":"68","author":"G\u00f3mez-Outes","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2021020808553751100_euaa274-B7","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.amjmed.2016.06.045","article-title":"Causes of death and influencing factors in patients with atrial fibrillation","volume":"129","author":"Fauchier","year":"2016","journal-title":"Am J Med"},{"key":"2021020808553751100_euaa274-B8","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ejim.2018.05.016","article-title":"Increased burden of comorbidities and risk of cardiovascular death in atrial fibrillation patients in Europe over ten years: a comparison between EORP-AF pilot and EHS-AF registries","volume":"55","author":"Proietti","year":"2018","journal-title":"Eur J Intern Med"},{"key":"2021020808553751100_euaa274-B9","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1093\/eurheartj\/ehs071","article-title":"Nurse-led care vs. usual care for patients with atrial fibrillation: results of a randomized trial of integrated chronic care vs. routine clinical care in ambulatory patients with atrial fibrillation","volume":"33","author":"Hendriks","year":"2012","journal-title":"Eur Heart J"},{"key":"2021020808553751100_euaa274-B10","first-page":"1947","article-title":"Integrated care in atrial fibrillation: a systematic review and meta-analysis","volume":"103","author":"Gallagher","year":"2017","journal-title":"Heart"},{"key":"2021020808553751100_euaa274-B11","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nrcardio.2017.153","article-title":"The ABC pathway: an integrated approach to improve AF management","volume":"14","author":"Lip","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"2021020808553751100_euaa274-B12","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.amjmed.2018.06.012","article-title":"Improved outcomes by integrated care of anticoagulated patients with atrial fibrillation using the simple ABC (Atrial Fibrillation Better Care) pathway","volume":"131","author":"Proietti","year":"2018","journal-title":"Am J Med"},{"key":"2021020808553751100_euaa274-B13","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.mayocp.2018.10.022","article-title":"Integrated care management of patients with atrial fibrillation and risk of cardiovascular events","volume":"94","author":"Pastori","year":"2019","journal-title":"Mayo Clin Proc"},{"key":"2021020808553751100_euaa274-B14","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1055\/s-0039-1693516","article-title":"Improved population-based clinical outcomes of patients with atrial fibrillation by compliance with the simple ABC (Atrial Fibrillation Better Care) pathway for integrated care management: a nationwide cohort study","volume":"119","author":"Yoon","year":"2019","journal-title":"Thromb Haemost"},{"key":"2021020808553751100_euaa274-B15","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/europace\/eut373","article-title":"A prospective survey in European Society of Cardiology member countries of atrial fibrillation management: baseline results of EURObservational Research Programme Atrial Fibrillation (EORP-AF) Pilot General Registry","volume":"16","author":"Lip","year":"2014","journal-title":"Europace"},{"key":"2021020808553751100_euaa274-B16","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1093\/eurheartj\/ehu374","article-title":"Prognosis and treatment of atrial fibrillation patients by European cardiologists: one year follow-up of the EURObservational Research Programme-Atrial Fibrillation General Registry Pilot Phase (EORP-AF Pilot registry)","volume":"35","author":"Lip","year":"2014","journal-title":"Eur Heart J"},{"key":"2021020808553751100_euaa274-B17","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijcard.2018.05.034","article-title":"Changes to oral anticoagulant therapy and risk of death over a 3-year follow-up of a contemporary cohort of European patients with atrial fibrillation final report of the EURObservational Research Programme on Atrial Fibrillation (EORP-AF) pilot general registry","volume":"271","author":"Boriani","year":"2018","journal-title":"Int J Cardiol"},{"key":"2021020808553751100_euaa274-B18","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/europace\/eux301","article-title":"Contemporary stroke prevention strategies in 11 096 European patients with atrial fibrillation: a report from the EURObservational Research Programme on Atrial Fibrillation (EORP-AF) Long-Term General Registry","volume":"20","author":"Boriani","year":"2018","journal-title":"Europace"},{"key":"2021020808553751100_euaa274-B19","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/europace\/euz032","article-title":"Association between antithrombotic treatment and outcomes at 1-year follow-up in patients with atrial fibrillation: the EORP-AF General Long-Term Registry","volume":"21","author":"Boriani","year":"2019","journal-title":"Europace"},{"key":"2021020808553751100_euaa274-B20","volume-title":"Practical Statistics for Medical Research","author":"Altman","year":"1991"},{"key":"2021020808553751100_euaa274-B21","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1093\/europace\/euz209","article-title":"Integrated specialized atrial fibrillation clinics reduce all-cause mortality: post hoc analysis of a randomized clinical trial","volume":"21","author":"Hendriks","year":"2019","journal-title":"Europace"},{"key":"2021020808553751100_euaa274-B22","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002950","article-title":"An integrated management approach to atrial fibrillation","volume":"5","author":"Carter","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"2021020808553751100_euaa274-B23","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.jacc.2020.01.052","article-title":"Mobile health technology to improve care for patients with atrial fibrillation","volume":"75","author":"Guo","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2021020808553751100_euaa274-B24","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1016\/j.mayocp.2019.06.012","article-title":"Long-term relationship between atrial fibrillation, multimorbidity and oral anticoagulant drug use","volume":"94","author":"Proietti","year":"2019","journal-title":"Mayo Clin Proc"}],"container-title":["EP Europace"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/europace\/article-pdf\/23\/2\/174\/36209375\/euaa274.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/europace\/article-pdf\/23\/2\/174\/36209375\/euaa274.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T19:30:35Z","timestamp":1612812635000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/23\/2\/174\/5917364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,2]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,10,2]]},"published-print":{"date-parts":[[2021,2,5]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euaa274","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,2,1]]},"published":{"date-parts":[[2020,10,2]]}}}