{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:50:33Z","timestamp":1793242233125,"version":"4.5.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study is to prospectively assess the feasibility and safety of left bundle branch pacing (LBBP) when compared with right ventricular pacing (RVP) during mid-long-term follow-up in a large cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Patients (n\u2009=\u2009554) indicated for pacemaker implantation were prospectively and consecutively enrolled and were non-randomized divided into LBBP group and RVP group. The levels of cTnT and N-terminal pro-B type natriuretic peptide were measured and compared within 2\u2009days post-procedure between two groups. Implant characteristics, procedure-related complications, and clinical outcomes were also compared. Pacing thresholds, sensing, and impedance were assessed during procedure and follow-up. Left bundle branch pacing was feasible with a success rate of 94.8% with high incidence of LBB potential (89.9%), selective LBBP (57.8%), and left deviation of paced QRS axis (79.7%) with mean Sti-LVAT of 65.07\u2009\u00b1\u20098.58\u2009ms. Paced QRS duration was significantly narrower in LBBP when compared with RVP (132.02\u2009\u00b1\u20097.93 vs. 177.68\u2009\u00b1\u200915.58\u2009ms, P\u2009&amp;lt;\u20090.0001) and the pacing parameters remained stable in two groups during 18 months follow-up. cTnT elevation was more significant in LBBP when compared with RVP within 2\u2009days post-procedure (baseline: 0.03\u2009\u00b1\u20090.03 vs. 0.02\u2009\u00b1\u20090.03\u2009ng\/mL, P\u2009=\u20090.002; 1\u2009day post-procedure: 0.13\u2009\u00b1\u20090.09 vs. 0.04\u2009\u00b1\u20090.03\u2009ng\/mL, P\u2009&amp;lt;\u20090.001; 2\u2009days post-procedure: 0.10\u2009\u00b1\u20090.08 vs. 0.03\u2009\u00b1\u20090.08\u2009ng\/mL, P\u2009&amp;lt;\u20090.001). The complications and cardiac outcomes were not significantly different between two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Left bundle branch pacing was feasible in bradycardia patients associated with stable pacing parameters during 18 months follow-up. Paced QRS duration was significantly narrower than that of RVP. Though cTnT elevation was more significant in LBBP within 2\u2009days post-procedure, the complications, and cardiac outcomes were not significantly different between two groups.<\/jats:p><\/jats:sec>","DOI":"10.1093\/europace\/euaa294","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T12:13:05Z","timestamp":1605960785000},"page":"ii36-ii44","source":"Crossref","is-referenced-by-count":70,"title":["The feasibility and safety of left bundle branch pacing vs. right ventricular pacing after mid-long-term follow-up: a single-centre experience"],"prefix":"10.1093","volume":"22","author":[{"given":"Xueying","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Shanghai Institution of Cardiovascular Disease, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinchun","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institution of Cardiovascular Disease, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institution of Cardiovascular Disease, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institution of Cardiovascular Disease, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengmei","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institution of Cardiovascular Disease, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institution of Cardiovascular Disease, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiu","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institution of Cardiovascular Disease, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangang","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institution of Cardiovascular Disease, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institution of Cardiovascular Disease, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,28]]},"reference":[{"key":"2020122812094423300_euaa294-B1","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1161\/01.CIR.0000150336.86033.8D","article-title":"Detrimental ventricular remodeling in patients with congenital complete heart block and chronic right ventricular apical 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