{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:46:24Z","timestamp":1787507184054,"version":"build-2736575974"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>His-bundle pacing (HBP) can be achieved in either atrial-side HBP (aHBP) or ventricular-side HBP (vHBP). The study compared the pacing parameters and electrophysiological characteristics between aHBP and vHBP in bradycardia patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Fifty patients undergoing HBP implantation assisted by visualization of the tricuspid valvular annulus (TVA) were enrolled. The HBP lead position was identified by TVA angiography. Twenty-five patients were assigned to undergo aHBP and compared with 25 patients who underwent vHBP primarily in a prospective and randomized fashion. Pacing parameters and echocardiography were routinely assessed at implant and 3-month follow-up. His-bundle pacing was successfully performed in 45 patients (90% success rate with 44.4% aHBP and 55.6% vHBP). The capture threshold was lower in vHBP than aHBP at implant (vHBP: 1.1\u2009\u00b1\u20090.5 vs. aHBP: 1.4\u2009\u00b1\u20090.4\u2009V\/1.0\u2009ms, P\u2009=\u20090.014) and 3-month follow-up (vHBP: 0.8\u2009\u00b1\u20090.4 vs. aHBP: 1.7\u2009\u00b1\u20090.8 V\/0.4\u2009ms, P\u2009&amp;lt;\u20090.001). The R-wave amplitude was higher in vHBP than in aHBP at implant (vHBP: 4.5\u2009\u00b1\u20091.4 vs. aHBP: 2.0\u2009\u00b1\u20090.8\u2009mV, P\u2009&amp;lt;\u20090.001) and at 3-month follow-up (vHBP: 4.4\u2009\u00b1\u20091.5 vs. aHBP: 1.8\u2009\u00b1\u20090.7\u2009mV, P\u2009&amp;lt;\u20090.001). No procedure-related complications and aggravation of tricuspid valve regurgitation were observed in most patients and echocardiographic assessment of cardiac function remained in the normal range in all patients during the follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that vHBP features a low and stable pacing capture threshold and high R-wave amplitude, suggesting better pacing mode management and battery longevity can be achieved by HBP in the ventricular side.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euaa309","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T19:20:39Z","timestamp":1600802439000},"page":"ii27-ii35","source":"Crossref","is-referenced-by-count":11,"title":["Electrical characteristics of pacing different portions of the His bundle in bradycardia patients"],"prefix":"10.1093","volume":"22","author":[{"given":"Yiran","family":"Hu","sequence":"first","affiliation":[{"name":"The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Xicheng District, Beijing 100037, China"},{"name":"Department of Cardiology and Macrovascular Disease, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Gu","sequence":"additional","affiliation":[{"name":"The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Xicheng District, Beijing 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hua","sequence":"additional","affiliation":[{"name":"The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Xicheng District, Beijing 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Niu","sequence":"additional","affiliation":[{"name":"The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Xicheng District, Beijing 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Fuwai Hospital, National Center for Cardiovascular Disease, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhua","family":"Chen","sequence":"additional","affiliation":[{"name":"The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Xicheng District, Beijing 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nixiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Xicheng District, Beijing 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Liu","sequence":"additional","affiliation":[{"name":"The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Xicheng District, Beijing 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Xicheng District, Beijing 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,28]]},"reference":[{"key":"2020122812094989000_euaa309-B1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41569-019-0224-z","article-title":"Permanent His bundle pacing: shaping the future of physiological ventricular pacing","volume":"17","author":"Sharma","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"2020122812094989000_euaa309-B2","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1093\/europace\/euy058","article-title":"Permanent His-bundle pacing: a systematic literature review and meta-analysis","volume":"20","author":"Zanon","year":"2018","journal-title":"Europace"},{"key":"2020122812094989000_euaa309-B3","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1016\/j.jacc.2018.02.048","article-title":"Clinical outcomes of his bundle pacing compared to right ventricular pacing","volume":"71","author":"Abdelrahman","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2020122812094989000_euaa309-B4","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jacep.2015.09.012","article-title":"Electrophysiologic insights into site of atrioventricular block: lessons from permanent His bundle pacing","volume":"1","author":"Vijayaraman","year":"2015","journal-title":"JACC Clin Electrophysiol"},{"key":"2020122812094989000_euaa309-B5","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s00276-004-0302-7","article-title":"A macroscopic anatomical investigation of atrioventricular bundle locational variation relative to the membranous part of the ventricular septum in elderly human hearts","volume":"27","author":"Kawashima","year":"2005","journal-title":"Surg Radiol Anat"},{"key":"2020122812094989000_euaa309-B6","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1111\/jce.14140","article-title":"Visualization of tricuspid valve annulus for implantation of His bundle pacing in patients with symptomatic bradycardia","volume":"30","author":"Gu","year":"2019","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2020122812094989000_euaa309-B7","first-page":"e350\u2013408","article-title":"ACC\/AHA\/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC\/AHA\/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices): developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons","volume":"117","author":"Epstein","year":"2008","journal-title":"Circulation"},{"key":"2020122812094989000_euaa309-B8","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.hrthm.2017.10.039","article-title":"Permanent His bundle pacing: recommendations from a Multicenter His Bundle Pacing Collaborative Working Group for standardization of definitions, implant measurements, and follow-up","volume":"15","author":"Vijayaraman","year":"2018","journal-title":"Heart Rhythm"},{"key":"2020122812094989000_euaa309-B9","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1161\/CIRCEP.111.968834","article-title":"Autopsy analysis of the implantation site of a permanent selective direct his bundle pacing lead","volume":"5","author":"Correa de Sa","year":"2012","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2020122812094989000_euaa309-B10","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.hrthm.2013.01.027","article-title":"Imaging evaluation of implantation site of permanent direct His bundle pacing lead","volume":"11","author":"Vijayaraman","year":"2014","journal-title":"Heart Rhythm"},{"key":"2020122812094989000_euaa309-B11","first-page":"425","article-title":"Subvalvular His bundle pacing for pseudo-pacemaker syndrome and mitral regurgitation","volume":"4","author":"Shah","year":"2018","journal-title":"Heart Rhythm Case Rep"},{"key":"2020122812094989000_euaa309-B12","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1111\/jce.14064","article-title":"His bundle pacing, learning curve, procedure characteristics, safety, and feasibility: insights from a large international observational study","volume":"30","author":"Keene","year":"2019","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2020122812094989000_euaa309-B13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.hrthm.2016.09.016","article-title":"Permanent His-bundle pacing in patients with prosthetic cardiac valves","volume":"14","author":"Sharma","year":"2017","journal-title":"Heart Rhythm"},{"key":"2020122812094989000_euaa309-B14","first-page":"244","article-title":"Permanent His-bundle pacing from the right atrium in patients with prosthetic tricuspid valve","volume":"5","author":"Fuentes Rojas","year":"2019","journal-title":"Heart Rhythm Case Rep"},{"key":"2020122812094989000_euaa309-B15","first-page":"437","article-title":"The influence of His bundle pacing on tricuspid valve functioning using three-dimensional echocardiography","volume":"4","author":"Hasumi","year":"2018","journal-title":"Heart Rhythm Case Rep"}],"container-title":["EP Europace"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/europace\/article-pdf\/22\/Supplement_2\/ii27\/35204049\/euaa309.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/europace\/article-pdf\/22\/Supplement_2\/ii27\/35204049\/euaa309.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T12:12:28Z","timestamp":1609157548000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/22\/Supplement_2\/ii27\/6054246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":15,"journal-issue":{"issue":"Supplement_2","published-online":{"date-parts":[[2020,12,28]]},"published-print":{"date-parts":[[2020,12,26]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euaa309","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12]]},"published":{"date-parts":[[2020,12]]}}}