{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:32:25Z","timestamp":1790688745090,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T00:00:00Z","timestamp":1608940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Science & Technology Pillar Program"},{"name":"Twelfth Five-year Plan Period of China","award":["2011BAI11B12"],"award-info":[{"award-number":["2011BAI11B12"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270363"],"award-info":[{"award-number":["81270363"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870301"],"award-info":[{"award-number":["81870301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims\u2003<\/jats:title>\n                  <jats:p>The roles of radiofrequency catheter ablation (RFCA) and pharmacotherapy in treating persistent and long-standing persistent atrial fibrillation (AF) have not been sufficiently investigated. We conducted a multicentre, randomized, controlled trial to compare the effects of RFCA and pharmacotherapy on the prognosis of these patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results\u2003<\/jats:title>\n                  <jats:p>A total of 648 patients with persistent and long-standing persistent AF were enrolled from 30 centres and randomized to either the ablation group (n\u2009=\u2009327) or the pharmacotherapy group (n\u2009=\u2009321). After 54.2\u2009\u00b1\u200910.6\u2009months of follow-up, the primary endpoints occurred significantly more rarely in the ablation group than in the pharmacotherapy group (10.4% vs. 17.4%; hazard ratio 0.59, 95% confidence interval 0.48\u20130.75; P\u2009&amp;lt;\u20090.001). The incidence of stroke\/transient ischaemic attack (TIA) was significantly lower in the ablation group (4.2% vs. 7.2%, P\u2009&amp;lt;\u20090.001). Likewise, the incidence of new-onset congestive heart failure (CHF) was lower in the ablation group (2.8% vs. 7.2%, P\u2009&amp;lt;\u20090.001). More patients had sinus rhythm in the ablation group than in the pharmacotherapy group (60.6% vs. 20.9%, P\u2009&amp;lt;\u20090.001), but fewer patients were on antiarrhythmic drugs (24.4% vs. 41.6%, P\u2009&amp;lt;\u20090.001) and warfarin (60.8% vs. 83.9%, P\u2009=\u20090.001). Both the 6-min walk distance and the quality of life (QoL) were improved in the ablation group at the end of follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion\u2003<\/jats:title>\n                  <jats:p>In patients with persistent and long-standing persistent AF, RFCA-based treatment was superior to pharmacotherapy in decreasing stroke\/TIA and new-onset CHF and improving QoL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaa356","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T12:15:14Z","timestamp":1605528914000},"page":"731-739","source":"Crossref","is-referenced-by-count":37,"title":["Long-term observation of catheter ablation vs. pharmacotherapy in the management of persistent and long-standing persistent atrial fibrillation (CAPA study)"],"prefix":"10.1093","volume":"23","author":[{"given":"Gang","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan university, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan university, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Third People\u2019s Hospital of Chengdu, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan university, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, 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