{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:14:08Z","timestamp":1790007248576,"version":"4.0.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Allgemeine Ortskrankenkasse"},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["NH\/16\/2\/32499"],"award-info":[{"award-number":["NH\/16\/2\/32499"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Present society is constantly ageing and elderly frequently suffer from conditions that are difficult and\/or costly to treat if detected late. Effective screening of the elderly is therefore needed so that those requiring detailed clinical work-up are identified early. We present a prospective validation of a screening strategy based on a Polyscore of seven predominantly autonomic, non-invasive risk markers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Within a population-based survey in Germany (INVADE study), participants aged \u226560\u2009years were enrolled between August 2013 and February 2015. Seven prospectively defined Polyscore components were obtained during 30-min continuous recordings of electrocardiogram, blood pressure, and respiration. Out of 1956 subjects, 168 were excluded due to atrial fibrillation, implanted pacemaker, or unsuitable recordings. All-cause mortality over a median 4-year follow-up was prospectively defined as the primary endpoint. The Polyscore divided the investigated population (n\u2009=\u20091788, median age: 72\u2009years, females: 58%) into three predefined groups with low (n\u2009=\u20091405, 78.6%), intermediate (n\u2009=\u2009326, 18.2%), and high risk (n\u2009=\u200957, 3.2%). During the follow-up, 82 (4.6%) participants died. Mortality in the Polyscore-defined risk groups was 3.4%, 7.4%, and 17.5%, respectively (P\u2009&amp;lt;\u20090.0001). The Polyscore-based mortality prediction was independent of Framingham score, diabetes, chronic kidney disease, and major stroke and\/or myocardial infarction history. It was particularly effective in those aged &amp;lt;75\u2009years (n\u2009=\u20091145).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The Polyscore-based mortality risk assessment from short-term non-invasive recordings is effective in the elderly general population, especially those aged 60\u201374\u2009years. Implementation of a comprehensive Polyscore screening of this age group is proposed to advance preventive medical care.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaa359","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T20:14:56Z","timestamp":1604952896000},"page":"789-796","source":"Crossref","is-referenced-by-count":8,"title":["Polyscore of autonomic parameters for risk stratification of the elderly general population: the Polyscore study"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0033-6941","authenticated-orcid":false,"given":"Alexander","family":"Steger","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin I, Technische Universit\u00e4t M\u00fcnchen, Ismaninger Str. 22, 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dommasch","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin I, Technische Universit\u00e4t M\u00fcnchen, Ismaninger Str. 22, 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin I, Technische Universit\u00e4t M\u00fcnchen, Ismaninger Str. 22, 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Sinnecker","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin I, Technische Universit\u00e4t M\u00fcnchen, Ismaninger Str. 22, 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina M","family":"Huster","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin I, Technische Universit\u00e4t M\u00fcnchen, Ismaninger Str. 22, 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Gotzler","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin I, Technische Universit\u00e4t M\u00fcnchen, Ismaninger Str. 22, 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Othmar","family":"Gotzler","sequence":"additional","affiliation":[{"name":"INVADE Study Group, Karl-B\u00f6hm-Str. 32, 85598 Baldham, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Hapfelmeier","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Statistics and Epidemiology, Technische Universit\u00e4t M\u00fcnchen, Grillparzerstr. 18, 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Ulm","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Statistics and Epidemiology, Technische Universit\u00e4t 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