{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:38:42Z","timestamp":1790217522783,"version":"4.1.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Italian Ministry of Health","award":["RC 2017 R659\/17-CCM698"],"award-info":[{"award-number":["RC 2017 R659\/17-CCM698"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The aim of this registry was to evaluate the additional prognostic value of a composite cardiac magnetic resonance (CMR)-based risk score over standard-of-care (SOC) evaluation in a large cohort of consecutive unselected non-ischaemic cardiomyopathy (NICM) patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In the DERIVATE registry (www.clinicaltrials.gov\/registration: RCT#NCT03352648), 1000 (derivation cohort) and 508 (validation cohort) NICM patients with chronic heart failure (HF) and left ventricular ejection fraction &amp;lt;50% were included. All-cause mortality and major adverse arrhythmic cardiac events (MAACE) were the primary and secondary endpoints, respectively. During a median follow-up of 959\u2009days, all-cause mortality and MAACE occurred in 72 (7%) and 93 (9%) patients, respectively. Age and &amp;gt;3 segments with midwall fibrosis on late gadolinium enhancement (LGE) were the only independent predictors of all-cause mortality (HR: 1.036, 95% CI: 1.0117\u20131.056, P\u2009&amp;lt;\u20090.001 and HR: 2.077, 95% CI: 1.211\u20133.562, P\u2009=\u20090.008, respectively). For MAACE, the independent predictors were male gender, left ventricular end-diastolic volume index by CMR (CMR-LVEDVi), and &amp;gt;3 segments with midwall fibrosis on LGE (HR: 2.131, 95% CI: 1.231\u20133.690, P\u2009=\u20090.007; HR: 3.161, 95% CI: 1.750\u20135.709, P\u2009&amp;lt;\u20090.001; and HR: 1.693, 95% CI: 1.084\u20132.644, P\u2009=\u20090.021, respectively). A composite clinical and CMR-based risk score provided a net reclassification improvement of 63.7% (P\u2009&amp;lt;\u20090.001) for MAACE occurrence when added to the model based on SOC evaluation. These findings were confirmed in the validation cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In a large multicentre, multivendor cohort registry reflecting daily clinical practice in NICM work-up, a composite clinical and CMR-based risk score provides incremental prognostic value beyond SOC evaluation, which may have impact on the indication of implantable cardioverter-defibrillator implantation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaa401","type":"journal-article","created":{"date-parts":[[2020,12,6]],"date-time":"2020-12-06T20:07:30Z","timestamp":1607285250000},"page":"1072-1083","source":"Crossref","is-referenced-by-count":56,"title":["CarDiac magnEtic Resonance for prophylactic Implantable-cardioVerter defibrillAtor ThErapy in Non-Ischaemic dilated CardioMyopathy: an international Registry"],"prefix":"10.1093","volume":"23","author":[{"given":"Andrea Igoren","family":"Guaricci","sequence":"first","affiliation":[{"name":"University Cardiology Unit, Policlinic University Hospital, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Giorgio","family":"Masci","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Department, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Muscogiuri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Guglielmo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8261-4529","authenticated-orcid":false,"given":"Andrea","family":"Baggiano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fusini","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9948-0301","authenticated-orcid":false,"given":"Valentina","family":"Lorenzoni","sequence":"additional","affiliation":[{"name":"Institute of Management, Scuola Superiore Sant'Anna, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Martini","sequence":"additional","affiliation":[{"name":"Scienze Radiologiche, Department of Medicine and Surgery, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Andreini","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Giulia","family":"Pavon","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, CMR Center, University Hospital Lausanne, CHUV, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni D","family":"Aquaro","sequence":"additional","affiliation":[{"name":"U.O.C. Risonanza Magnetica per Immagini, Fondazione G. Monasterio CNR-Regione Toscana Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9042-340X","authenticated-orcid":false,"given":"Andrea","family":"Barison","sequence":"additional","affiliation":[{"name":"U.O.C. Risonanza Magnetica per Immagini, Fondazione G. Monasterio CNR-Regione Toscana Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Todiere","sequence":"additional","affiliation":[{"name":"U.O.C. Risonanza Magnetica per Immagini, Fondazione G. Monasterio CNR-Regione Toscana Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark G","family":"Rabbat","sequence":"additional","affiliation":[{"name":"Loyola University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Tat","sequence":"additional","affiliation":[{"name":"Loyola University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Raineri","sequence":"additional","affiliation":[{"name":"Department of Cardiology,\u00a0Citt\u00e0 della salute e della Scienza - Ospedale Molinette -Turin, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"Valentini","sequence":"additional","affiliation":[{"name":"Department of Radiology, Fondazione IRCCS Policlinico S.Matteo, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akos","family":"Varga-Szemes","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U. Joseph","family":"Schoepf","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo N","family":"De Cecco","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA"},{"name":"Division of Cardiothoracic Imaging, Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6212-3063","authenticated-orcid":false,"given":"Jan","family":"Bogaert","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Dobrovie","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Symons","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Focardi","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalaura","family":"Gismondi","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Lozano-Torres","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e8 F","family":"Rodriguez-Palomares","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00edn Biom\u00e9dica en Red-CV, CIBER CV. 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