{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T09:43:19Z","timestamp":1780998199604,"version":"3.54.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wellcome Trust Fellowship"},{"name":"Basic Biomedical Sciences","award":["214290\/Z\/18\/Z"],"award-info":[{"award-number":["214290\/Z\/18\/Z"]}]},{"name":"Personalised In-Silico Cardiology"},{"name":"European Union\u2019s Horizon 2020 research and innovation programme"},{"name":"Marie Sklodowska-Curie","award":["764738"],"award-info":[{"award-number":["764738"]}]},{"name":"CompBioMed 1 and 2 Centre of Excellence in Computational Biomedicine"},{"name":"European Commission Horizon 2020 research and innovation programme","award":["675451"],"award-info":[{"award-number":["675451"]}]},{"name":"European Commission Horizon 2020 research and innovation programme","award":["823712"],"award-info":[{"award-number":["823712"]}]},{"name":"NC3Rs Infrastructure for Impact Award","award":["NC\/P001076\/1"],"award-info":[{"award-number":["NC\/P001076\/1"]}]},{"name":"TransQST project"},{"name":"Innovative Medicines Initiative 2 Joint Undertaking","award":["116030"],"award-info":[{"award-number":["116030"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme"},{"DOI":"10.13039\/501100005617","name":"Oxford BHF Centre of Research Excellence","doi-asserted-by":"crossref","award":["RE\/13\/1\/30181"],"award-info":[{"award-number":["RE\/13\/1\/30181"]}],"id":[{"id":"10.13039\/501100005617","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Theo-Rossi di Montelera (TRM) foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Develop, calibrate and evaluate with clinical data a human electromechanical modelling and simulation framework for multiscale, mechanistic investigations in healthy and post-myocardial infarction (MI) conditions, from ionic to clinical biomarkers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Human healthy and post-MI electromechanical simulations were conducted with a novel biventricular model, calibrated and evaluated with experimental and clinical data, including torso\/biventricular anatomy from clinical magnetic resonance, state-of-the-art human-based membrane kinetics, excitation\u2013contraction and active tension models, and orthotropic electromechanical coupling. Electromechanical remodelling of the infarct\/ischaemic region and the border zone were simulated for ischaemic, acute, and chronic states in a fully transmural anterior infarct and a subendocardial anterior infarct. The results were compared with clinical electrocardiogram and left ventricular ejection fraction (LVEF) data at similar states. Healthy model simulations show LVEF 63%, with 11% peak systolic wall thickening, QRS duration and QT interval of 100\u2009ms and 330\u2009ms. LVEF in ischaemic, acute, and chronic post-MI states were 56%, 51%, and 52%, respectively. In linking the three post-MI simulations, it was apparent that elevated resting potential due to hyperkalaemia in the infarcted region led to ST-segment elevation, while a large repolarization gradient corresponded to T-wave inversion. Mechanically, the chronic stiffening of the infarct region had the benefit of improving systolic function by reducing infarct bulging at the expense of reducing diastolic function by inhibiting inflation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our human-based multiscale modelling and simulation framework enables mechanistic investigations into patho-physiological electrophysiological and mechanical behaviour and can serve as testbed to guide the optimization of pharmacological and electrical therapies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaa405","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T20:22:01Z","timestamp":1607977321000},"page":"i143-i152","source":"Crossref","is-referenced-by-count":34,"title":["Human biventricular electromechanical simulations on the progression of electrocardiographic and mechanical abnormalities in post-myocardial infarction"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5325-909X","authenticated-orcid":false,"given":"Zhinuo J","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Computer Science, University of Oxford, Wolfson Building, Parks Road, Oxford OX1 3QD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Santiago","sequence":"additional","affiliation":[{"name":"Department of Computer Applications in Science and Engineering, Barcelona Supercomputing Centre (BSC), Barcelona, Spain"},{"name":"ELEM Biotech, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Oxford, Wolfson Building, Parks Road, Oxford OX1 3QD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Oxford, Wolfson Building, Parks Road, Oxford OX1 3QD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Margara","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Oxford, Wolfson Building, Parks Road, Oxford OX1 3QD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Levrero-Florencio","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Oxford, Wolfson Building, Parks Road, Oxford OX1 3QD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1134-3036","authenticated-orcid":false,"given":"Arka","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging Sciences, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging Sciences, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Dall'Armellina","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging Sciences, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Department of Computer Applications in Science and Engineering, Barcelona Supercomputing Centre (BSC), Barcelona, Spain"},{"name":"ELEM Biotech, Barcelona, 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