{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T17:44:12Z","timestamp":1784051052712,"version":"3.55.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T00:00:00Z","timestamp":1612656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>In patients with post-myocardial infarction (post-MI) ventricular tachycardia (VT), the presence of myocardial calcification (MC) may prevent heating of a subepicardial VT substrate contributing to endocardial ablation failure. The aims of this study were to assess the prevalence of MC in patients with post-MI VT and evaluate the impact of MC on outcome after endocardial ablation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In 158 patients, the presence of MC was retrospectively assessed on fluoroscopy recordings in seven standard projections obtained during pre-procedural coronary angiograms. Myocardial calcification, defined as a distinct radiopaque area that moved synchronously with the cardiac contraction, was detected in 30 patients (19%). After endocardial ablation, only 6 patients (20%) with MC were rendered non-inducible compared with 56 (44%) without MC (P\u2009=\u20090.033) and of importance, 8 (27%) remained inducible for the clinical VT [compared with 9 (6%) patients without MC; P\u2009=\u20090.003] requiring therapy escalation. After a median follow-up of 31\u2009months, 61 patients (39%) had VT recurrence and 47 (30%) died. Patients with MC had a lower survival free from the composite endpoint of VT recurrence or therapy escalation at 24-month follow-up (26% vs. 59%; P\u2009=\u20090.003). Presence of MC (HR 1.69; P\u2009=\u20090.046), a lower LV ejection fraction (HR 1.03 per 1% decrease; P\u2009=\u20090.017), and non-complete procedural success (HR 2.42; P\u2009=\u20090.002) were independently associated with a higher incidence of VT recurrence or therapy escalation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Myocardial calcification was present in 19% of post-MI patients referred for VT ablation and was associated with a high incidence of endocardial ablation failure.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euab003","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:36:29Z","timestamp":1610670989000},"page":"1275-1284","source":"Crossref","is-referenced-by-count":6,"title":["Myocardial calcification is associated with endocardial ablation failure of post-myocardial infarction ventricular tachycardia"],"prefix":"10.1093","volume":"23","author":[{"given":"Marta","family":"de Riva","sequence":"first","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, C-05-P, PO Box 9600, 2300 RC Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Naruse","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, C-05-P, PO Box 9600, 2300 RC Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micaela","family":"Ebert","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, C-05-P, PO Box 9600, 2300 RC Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, C-05-P, PO Box 9600, 2300 RC Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur J","family":"Scholte","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, C-05-P, PO Box 9600, 2300 RC Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrianus P","family":"Wijnmaalen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, C-05-P, PO Box 9600, 2300 RC Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge A","family":"Trines","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, C-05-P, PO Box 9600, 2300 RC Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J","family":"Schalij","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, C-05-P, PO Box 9600, 2300 RC Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M","family":"Montero-Cabezas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, C-05-P, PO Box 9600, 2300 RC Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Zeppenfeld","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, C-05-P, PO Box 9600, 2300 RC Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,7]]},"reference":[{"key":"2021080909024184500_euab003-B1","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.jacc.2015.11.041","article-title":"Long-term success of irrigated radiofrequency catheter ablation of sustained ventricular tachycardia: post-approval THERMOCOOL VT 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