{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T14:24:01Z","timestamp":1778077441630,"version":"3.51.4"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Evidences suggest that recurrent atrial fibrillation (AF) is associated with left atrial (LA) remodelling. The goal of this study is to establish a method for assessment of LA remodelling and find predictors for the development of AF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This prospective study included patients without a history of AF who were evaluated using pulsed-wave tissue Doppler imaging (PW-TDI). P-wave onset to A\u2032-wave (PA\u2032 interval) was measured at the septal, lateral, anterior, and inferior mitral annulus. Abnormal LA activation pattern was defined as an upward LA activation over the coronary sinus and delayed activation anterior. Left atrial asynchrony was measured as (i) the difference between the septal and lateral PA\u2032 interval (DLS) and (ii) the standard deviation of all four PA\u2032 intervals (SD4-PA\u2032). The follow-up for AF recurrence (AF+) was based on symptoms and 7-day Holter electrocardiograms. Ninety-eight patients (mean age 58\u2009\u00b1\u200915\u2009years, 47% female) were included. During a follow-up of 28\u2009\u00b1\u20099\u2009months, AF was documented in 10%. More pronounced LA asynchrony was observed in AF+ group: DLS (AF+) 39\u2009\u00b1\u200916 vs. DLS (AF\u2212) 20\u2009\u00b1\u200911\u2009ms; P\u2009&amp;lt;\u20090.001, and SD4-PA\u2032 (AF+) 18.6\u2009\u00b1\u20096.4 vs. SD4-PA\u2032 (AF\u2212) 11.7\u2009\u00b1\u20094.2\u2009ms; P\u2009&amp;lt;\u20090.001. Abnormal LA activation was frequently observed in AF+ patients: 60% vs. 27%; P\u2009=\u20090.033. Electrocardiogram sign of Bachmann\u2019s bundle block (BBB) was associated with prolongation of SD4-PA\u2032: SD4-PA\u2032 (BBB+) vs. SD4-PA\u2032 (BBB\u2212) = 18\u2009\u00b1\u20096 vs. 13\u2009\u00b1\u20094.5\u2009ms; P\u2009=\u20090.007.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>More pronounced LA asynchrony and abnormal LA activation pattern were associated with new-onset AF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euab010","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T05:23:16Z","timestamp":1612416196000},"page":"1244-1251","source":"Crossref","is-referenced-by-count":6,"title":["Abnormal pattern of left atrial activation and asynchronous conduction predicted the occurrence of new atrial fibrillation: evidences for Bachmann\u2019s bundle block in atrial fibrillation pathophysiology"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2873-6779","authenticated-orcid":false,"given":"Timm","family":"Seew\u00f6ster","sequence":"first","affiliation":[{"name":"Department of Electrophysiology, HELIOS Kliniken GmbH, Heart Center Leipzig\u2014University Hospital of Cardiology, Struempellstr. 39, 04289 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8594-5163","authenticated-orcid":false,"given":"Kaloyan","family":"Marinov","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, HELIOS Kliniken GmbH, Heart Center Leipzig\u2014University Hospital of Cardiology, Struempellstr. 39, 04289 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"L\u00f6be","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, HELIOS Kliniken GmbH, Heart Center Leipzig\u2014University Hospital of Cardiology, Struempellstr. 39, 04289 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helge","family":"Knopp","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, HELIOS Kliniken GmbH, Heart Center Leipzig\u2014University Hospital of Cardiology, Struempellstr. 39, 04289 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sotirios","family":"Nedios","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, HELIOS Kliniken GmbH, Heart Center Leipzig"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5441-3906","authenticated-orcid":false,"given":"Andreas","family":"Bollmann","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, HELIOS Kliniken GmbH, Heart Center Leipzig\u2014University Hospital of Cardiology, Struempellstr. 39, 04289 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7610-1156","authenticated-orcid":false,"given":"Gerhard","family":"Hindricks","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, HELIOS Kliniken GmbH, Heart Center Leipzig\u2014University Hospital of Cardiology, Struempellstr. 39, 04289 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borislav","family":"Dinov","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, HELIOS Kliniken GmbH, Heart Center Leipzig\u2014University Hospital of Cardiology, Struempellstr. 39, 04289 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"2021080909024391800_euab010-B1","first-page":"48","article-title":"Maintenance of sinus rhythm with an ablation strategy in patients with atrial fibrillation is associated with a lower risk of stroke and death","volume":"98","author":"Hunter","year":"2012","journal-title":"Heart Br Card Soc"},{"key":"2021080909024391800_euab010-B2","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1001\/jama.1994.03510350050036","article-title":"Independent risk factors for atrial fibrillation in a population-based cohort. 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