{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T22:23:03Z","timestamp":1775168583494,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"The Independent Research Fund Denmark","award":["0134-00363B"],"award-info":[{"award-number":["0134-00363B"]}]},{"name":"The Novo Nordisk Foundation","award":["NNF20OC0065799"],"award-info":[{"award-number":["NNF20OC0065799"]}]},{"name":"The Novo Nordisk Foundation","award":["NNF18OC0031258"],"award-info":[{"award-number":["NNF18OC0031258"]}]},{"name":"The Aarno Koskelo Foundation"},{"name":"The Special Governmental Subsidy and the Finnish Cardiovascular Research Foundation"},{"name":"The Nordic ARVC Registry"},{"name":"Heart Centre Research Foundation at Rigshospitalet"},{"name":"The Swedish Heart-Lung Foundation"},{"name":"Donations Funds at Sk\u00e5ne University Hospital"},{"DOI":"10.13039\/501100005416","name":"Norwegian Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"name":"South Eastern Health Authorities, Norway"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Treatment with implantable cardioverter-defibrillators (ICD) is a cornerstone for prevention of sudden cardiac death in arrhythmogenic right ventricular cardiomyopathy (ARVC). We aimed at describing the complications associated with ICD treatment in a multinational cohort with long-term follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The Nordic ARVC registry was established in 2010 and encompasses a large multinational cohort of ARVC patients, including their clinical characteristics, treatment, and events during follow-up. We included 299 patients (66% males, median age 41\u2009years). During a median follow-up of 10.6\u2009years, 124 (41%) patients experienced appropriate ICD shock therapy, 28 (9%) experienced inappropriate shocks, 82 (27%) had a complication requiring surgery (mainly lead-related, n\u2009=\u200975), and 99 (33%) patients experienced the combined endpoint of either an inappropriate shock or a surgical complication. The crude rate of first inappropriate shock was 3.4% during the first year after implantation but decreased after the first year and plateaued over time. Contrary, the risk of a complication requiring surgery was 5.5% the first year and remained high throughout the study period. The combined risk of any complication was 7.9% the first year. In multivariate cox regression, presence of atrial fibrillation\/flutter was a risk factor for inappropriate shock (P\u2009&amp;lt;\u20090.05), whereas sex, age at implant, and device type were not (all P\u2009&amp;gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Forty-one percent of ARVC patients treated with ICD experienced potentially life-saving ICD therapy during long-term follow-up. A third of the patients experienced a complication during follow-up with lead-related complications constituting the vast majority.<\/jats:p><\/jats:sec>","DOI":"10.1093\/europace\/euab112","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T11:54:46Z","timestamp":1617969286000},"page":"306-312","source":"Crossref","is-referenced-by-count":16,"title":["Complications of implantable cardioverter-defibrillator treatment in arrhythmogenic right ventricular cardiomyopathy"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6855-1496","authenticated-orcid":false,"given":"Alex H\u00f8rby","family":"Christensen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev-Gentofte, Borgmester Ib Juuls Vej 1, DK-2730 Herlev, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5592-8717","authenticated-orcid":false,"given":"Pyotr G","family":"Platonov","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lund University, Lund, Sweden"},{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anneli","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Link\u00f6ping University, Link\u00f6ping, Sweden"},{"name":"Department of Health, Medicine and Caring Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik K","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Rootwelt-Norberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital, Rikshospitalet, Norway"},{"name":"Institute for Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia","family":"Dahlberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trine","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja Charlotte","family":"Frederiksen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiina","family":"Heli\u00f6","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Lung Center, Helsinki University Hospital, Helsinki, Finland"},{"name":"University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina H","family":"Haugaa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital, Rikshospitalet, Norway"},{"name":"Institute for Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Bundgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper H","family":"Svendsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"2022020820554071000_euab112-B1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/eurheartj\/ehq025","article-title":"Diagnosis of arrhythmogenic right ventricular cardiomyopathy\/dysplasia: proposed Modification of the Task Force Criteria","volume":"31","author":"Marcus","year":"2010","journal-title":"Eur Heart 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