{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:19:10Z","timestamp":1791537550108,"version":"4.3.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Nationale de la Recherche"},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["715093"],"award-info":[{"award-number":["715093"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Pulsed field ablation (PFA), a non-thermal ablative modality, may show different effects on the myocardial tissue compared to thermal ablation. Thus, this study aimed to compare the left atrial (LA) structural and mechanical characteristics after PFA vs. thermal ablation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Cardiac magnetic resonance was performed pre-ablation, acutely (&amp;lt;3\u2009h), and 3\u2009months post-ablation in 41 patients with paroxysmal atrial fibrillation (AF) undergoing pulmonary vein (PV) isolation with PFA (n\u2009=\u200918) or thermal ablation (n\u2009=\u200923, 16 radiofrequency ablations, 7 cryoablations). Late gadolinium enhancement (LGE), T2-weighted, and cine images were analysed. In the acute stage, LGE volume was 60% larger after PFA vs. thermal ablation (P\u2009&amp;lt;\u20090.001), and oedema on T2 imaging was 20% smaller (P\u2009=\u20090.002). Tissue changes were more homogeneous after PFA than after thermal ablation, with no sign of microvascular damage or intramural haemorrhage. In the chronic stage, the majority of acute LGE had disappeared after PFA, whereas most LGE persisted after thermal ablation. The maximum strain on PV antra, the LA expansion index, and LA active emptying fraction declined acutely after both PFA and thermal ablation but recovered at the chronic stage only with PFA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Pulsed field ablation induces large acute LGE without microvascular damage or intramural haemorrhage. Most LGE lesions disappear in the chronic stage, suggesting a specific reparative process involving less chronic fibrosis. This process may contribute to a preserved tissue compliance and LA reservoir and booster pump functions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euab155","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T12:02:41Z","timestamp":1622116961000},"page":"1767-1776","source":"Crossref","is-referenced-by-count":129,"title":["Pulsed field ablation prevents chronic atrial fibrotic changes and restrictive mechanics after catheter ablation for atrial fibrillation"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5427-5048","authenticated-orcid":false,"given":"Yosuke","family":"Nakatani","sequence":"first","affiliation":[{"name":"Department of Cardiac Pacing and Electrophysiology, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux, Avenue de Magellan, 33604 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumaya","family":"Sridi-Cheniti","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Imaging, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux, Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghassen","family":"Cheniti","sequence":"additional","affiliation":[{"name":"Department of Cardiac Pacing and Electrophysiology, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux, Avenue de Magellan, 33604 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4350-1652","authenticated-orcid":false,"given":"F Daniel","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Department of Cardiac Pacing and Electrophysiology, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux, Avenue de Magellan, 33604 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Goujeau","sequence":"additional","affiliation":[{"name":"Department of Cardiac Pacing and Electrophysiology, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux, Avenue de Magellan, 33604 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clementine","family":"Andr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Cardiac Pacing and Electrophysiology, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux, Avenue de Magellan, 33604 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Cardiac Pacing and Electrophysiology, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux, Avenue de Magellan, 33604 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Eggert","sequence":"additional","affiliation":[{"name":"Farapulse, Menlo Park, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Schneider","sequence":"additional","affiliation":[{"name":"Farapulse, Menlo Park, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raju","family":"Viswanathan","sequence":"additional","affiliation":[{"name":"Farapulse, Menlo Park, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Krisai","sequence":"additional","affiliation":[{"name":"Department of Cardiac Pacing and Electrophysiology, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux, Avenue de Magellan, 33604 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamitsu","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Pacing and Electrophysiology, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux, Avenue de Magellan, 33604 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Kamakura","sequence":"additional","affiliation":[{"name":"Department of Cardiac Pacing and Electrophysiology, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux, Avenue de Magellan, 33604 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3753-7883","authenticated-orcid":false,"given":"Konstantinos","family":"Vlachos","sequence":"additional","affiliation":[{"name":"Department of Cardiac Pacing and Electrophysiology, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux, Avenue de Magellan, 33604 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Derval","sequence":"additional","affiliation":[{"name":"Department of Cardiac Pacing and Electrophysiology, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux, Avenue de Magellan, 33604 Pessac, France"},{"name":"IHU LIRYC\u2014CHU Bordeaux\/Univ. 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