{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:19:23Z","timestamp":1768821563688,"version":"3.49.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"ZonMw Topzorg","award":["842001003"],"award-info":[{"award-number":["842001003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Pulmonary vein isolation (PVI) for atrial fibrillation (AF) has become increasingly safe and effective with the evolution of single-tip ablation catheters aided by contact force sensing (ST-CF) and single-shot devices such as the second-generation pulmonary vein ablation catheter (PVAC) Gold multi-electrode array. The multicentre randomized GOLD FORCE trial was conducted to evaluate non-inferiority of safety and efficacy of PVAC Gold PVI compared to ST-CF ablation for paroxysmal AF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The primary efficacy endpoint documented AF recurrence \u226530\u2009s was assessed by time-to-first-event analysis after a 90-day blanking period using repeated 7-day Holters. Secondary endpoints include acute success and procedural characteristics. Safety endpoints included procedural complications, stroke\/transient ischaemic attack (TIA), tamponade, bleeding, and access site complications. Two hundred and eight patients underwent randomization and PVI (103 assigned to PVAC Gold, 105 to ST-CF). Acute success rates were 95% and 97% for PVAC Gold and ST-CF, respectively. At 12\u2009months, AF recurrence was observed in 46.6% of the PVAC Gold group and in 26.2% of the ST-CF group [absolute efficacy difference 20.4% (95% confidence interval, CI 7.5\u201333.2%), hazard ratio 2.05 (95% CI 1.28\u20133.29), P\u2009=\u20090.003]. PVAC Gold had significantly shorter procedure and ablation times. Complication rates were 5.7% and 4.9% for PVAC Gold and ST-CF, respectively (P\u2009=\u20090.782).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In this multicentre randomized clinical trial, ablation with ST-CF and PVAC Gold ablation catheters non-inferiority for efficacy was not met. AF recurrence was significantly more frequent in the PVAC Gold group compared to single-tip contact force group. Both groups had similarly low rates of adverse events. PVAC Gold ablation had significantly shorter procedure and ablation times.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euab168","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T11:08:40Z","timestamp":1623755320000},"page":"1931-1938","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy and safety of the GOLD FORCE multicentre randomized clinical trial: multielectrode phased radiofrequency vs. irrigated radiofrequency single-tip catheter with contact force ablation for treatment of symptomatic paroxysmal atrial fibrillation"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9582-7224","authenticated-orcid":false,"given":"Lisette I S","family":"Wintgens","sequence":"first","affiliation":[{"name":"St. Antonius Hospital, Department of Cardiology, Koekoekslaan 1, 3435 Nieuwegein, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn N","family":"Klaver","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital, Department of Cardiology, Koekoekslaan 1, 3435 Nieuwegein, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moniek","family":"Maarse","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital, Department of Cardiology, Koekoekslaan 1, 3435 Nieuwegein, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan G","family":"Spitzer","sequence":"additional","affiliation":[{"name":"Praxisklinik Herz und Gef\u00e4\u00dfe Dresden, Akademische Lehrpraxisklinik der TU Dresden, Department of Cardiology, Dresden, Germany"},{"name":"Brandenburg University of Technology Cottbus-Senftenberg, Institute of Medical Technology, Department of Cardiology, Cottbus, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Langbein","sequence":"additional","affiliation":[{"name":"Praxisklinik Herz und Gef\u00e4\u00dfe Dresden, Akademische Lehrpraxisklinik der TU Dresden, Department of Cardiology, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J","family":"Swaans","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital, Department of Cardiology, Koekoekslaan 1, 3435 Nieuwegein, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent F","family":"Van Dijk","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital, Department of Cardiology, Koekoekslaan 1, 3435 Nieuwegein, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jippe C","family":"Balt","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital, Department of Cardiology, Koekoekslaan 1, 3435 Nieuwegein, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurits C E F","family":"Wijffels","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital, Department of Cardiology, Koekoekslaan 1, 3435 Nieuwegein, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan G P","family":"Tijssen","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Department of Cardiology, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8436-8635","authenticated-orcid":false,"given":"Arif","family":"Elvan","sequence":"additional","affiliation":[{"name":"Isala Clinics, Department of Cardiology, Zwolle, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-4220","authenticated-orcid":false,"given":"Lucas V A","family":"Boersma","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital, Department of Cardiology, Koekoekslaan 1, 3435 Nieuwegein, The Netherlands"},{"name":"Amsterdam UMC, Department of Cardiology, Amsterdam, The 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