{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:10:27Z","timestamp":1790017827922,"version":"4.0.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To establish a cardiovascular magnetic resonance (CMR)-based prediction model for complete systolic left ventricular ejection fraction (LVEF) recovery for the distinction of \u2018arrhythmia-induced\u2019 from \u2018arrhythmia-mediated\u2019 cardiomyopathy in patients with atrial tachyarrhythmias.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Two hundred and fifty-three tachyarrhythmia patients referred for catheter ablation were enrolled and underwent CMR baseline imaging; patients with a reduced LVEF &amp;lt;50% at baseline and CMR imaging at 3-month follow-up after successful rhythm restoration constituted the final study population (n\u2009=\u2009134). CMR at baseline consisted of standard functional cine imaging, determination of extracellular volume, and late gadolinium enhancement (LGE) imaging; follow-up CMR comprised standard functional cine imaging. Left ventricular end-diastolic volume index (LVEDVI) measurements were categorized in \u2018opposite\u2019, \u2018normal\u2019, and \u2018enlarged\u2019. At follow-up, 80% (107\/134) presented with complete LVEF recovery, while in 20% (27\/134) persistent LVEF impairment was observed. LVEDVI and LGE were independent predictors of complete LVEF recovery with LGE adding significant incremental value on logistic regression modelling. Model-derived probabilities for complete LVEF recovery in LVEDVI categories of opposite, normal, and enlarged for LGE negativity and positivity were 94%, 85%, and 29% and 77%, 55%, and 8%, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>CMR-derived assessment of LVEDVI category and LGE allowed for identification of arrhythmia-induced cardiomyopathy with acceptable discriminative performance. Probabilities for complete LVEF recovery for the combination of opposite LVEDVI\/LGE negativity and enlarged LVEDVI\/LGE positivity were 94% and 8%, respectively. The CMR-based prediction model of complete LVEF recovery can be used to perform upfront stratification in atrial tachyarrhythmia-related LVEF impairment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euab174","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T19:09:53Z","timestamp":1624734593000},"page":"12-19","source":"Crossref","is-referenced-by-count":6,"title":["Cardiovascular magnetic resonance-based predictors of complete left ventricular systolic functional recovery after rhythm restoration in patients with atrial tachyarrhythmia"],"prefix":"10.1093","volume":"24","author":[{"given":"Clara","family":"Stegmann","sequence":"first","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig at University of Leipzig, Struempellstr. 39, 04289 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosima","family":"Jahnke","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig at University of Leipzig, Struempellstr. 39, 04289 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lindemann","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig at University of Leipzig, Struempellstr. 39, 04289 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Oebel","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig at University of Leipzig, Struempellstr. 39, 04289 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Richter","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig at University of Leipzig, Struempellstr. 39, 04289 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5441-3906","authenticated-orcid":false,"given":"Andreas","family":"Bollmann","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig at University of Leipzig, Struempellstr. 39, 04289 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0323-4956","authenticated-orcid":false,"given":"Nikolaos","family":"Dagres","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig at University of Leipzig, Struempellstr. 39, 04289 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7610-1156","authenticated-orcid":false,"given":"Gerhard","family":"Hindricks","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig at University of Leipzig, Struempellstr. 39, 04289 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3528-7174","authenticated-orcid":false,"given":"Ingo","family":"Paetsch","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig at University of Leipzig, Struempellstr. 39, 04289 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"2022010817393788900_euab174-B1","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.jacc.2015.08.038","article-title":"Arrhythmia-induced cardiomyopathies: mechanisms, recognition, and management","volume":"66","author":"Gopinathannair","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2022010817393788900_euab174-B2","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1136\/heartjnl-2016-310391","article-title":"Pathophysiology, diagnosis and treatment of tachycardiomyopathy","volume":"103","author":"Martin","year":"2017","journal-title":"Heart"},{"key":"2022010817393788900_euab174-B3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ijcard.2013.12.180","article-title":"Tachycardia mediated cardiomyopathy: pathophysiology, mechanisms, clinical features and management","volume":"172","author":"Gupta","year":"2014","journal-title":"Int J Cardiol"},{"key":"2022010817393788900_euab174-B4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12968-020-00607-1","article-title":"Standardized cardiovascular magnetic resonance imaging (CMR) protocols: 2020 update","volume":"22","author":"Kramer","year":"2020","journal-title":"J Cardiovasc Magn Reson"},{"key":"2022010817393788900_euab174-B5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12968-020-00610-6","article-title":"Standardized image interpretation and post-processing in cardiovascular magnetic resonance - 2020 update: Society for Cardiovascular Magnetic Resonance (SCMR): Board of Trustees Task Force on Standardized Post-Processing","volume":"22","author":"Schulz-Menger","year":"2020","journal-title":"J Cardiovasc Magn Reson"},{"key":"2022010817393788900_euab174-B6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/(SICI)1097-0258(20000115)19:1<113::AID-SIM245>3.0.CO;2-O","article-title":"Categorizing a prognostic variable: review of methods, code for easy implementation and applications to decision-making about cancer treatments","volume":"19","author":"Mazumdar","year":"2000","journal-title":"Stat Med"},{"key":"2022010817393788900_euab174-B7","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1093\/ehjci\/jez232","article-title":"European Association of Cardiovascular Imaging expert consensus paper: a comprehensive review of cardiovascular magnetic resonance normal values of cardiac chamber size and aortic root in adults and recommendations for grading severity","volume":"20","author":"Petersen","year":"2019","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2022010817393788900_euab174-B8","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J"},{"key":"2022010817393788900_euab174-B9","doi-asserted-by":"crossref","first-page":"20168","DOI":"10.1038\/s41598-019-56213-4","article-title":"Relationship of extracellular volume assessed on cardiac magnetic resonance and serum cardiac troponins and natriuretic peptides with heart failure outcomes","volume":"9","author":"Yang","year":"2019","journal-title":"Sci Rep"},{"key":"2022010817393788900_euab174-B10","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1093\/ehjci\/jey034","article-title":"Myocardial native T1 and extracellular volume with healthy ageing and gender","volume":"19","author":"Rosmini","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2022010817393788900_euab174-B11","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"2022010817393788900_euab174-B12","doi-asserted-by":"crossref","DOI":"10.1002\/0471722146","volume-title":"Applied Logistic Regression","author":"Hosmer","year":"2000"},{"key":"2022010817393788900_euab174-B13","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1093\/europace\/euz248","article-title":"Combined single-session cardiovascular magnetic resonance: stress perfusion and three-dimensional pulmonary vein angiography for stratification of atrial fibrillation patients with chest pain syndromes prior to catheter ablation","volume":"21","author":"Oebel","year":"2019","journal-title":"Europace"},{"key":"2022010817393788900_euab174-B14","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1136\/adc.83.6.459","article-title":"Derivation versus validation","volume":"83","author":"Wade","year":"2000","journal-title":"Arch Dis Child"}],"container-title":["EP Europace"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/24\/1\/12\/42079836\/euab174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/24\/1\/12\/42079836\/euab174.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T17:39:55Z","timestamp":1641663595000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/24\/1\/12\/6323986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,19]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,7,19]]},"published-print":{"date-parts":[[2022,1,4]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euab174","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,1]]},"published":{"date-parts":[[2021,7,19]]}}}