{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:20:40Z","timestamp":1792268440180,"version":"4.4.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>In arrhythmogenic cardiomyopathy (ACM), sustained ventricular tachycardia (VT) typically displays a left bundle branch block (LBBB) morphology while a right bundle branch block (RBBB) morphology is rare. The present study assesses the VT morphology in ACM patients with sustained VT and their clinical and genetic characteristics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Twenty-six centres from 11 European countries provided information on 954 ACM patients who had \u22651 episode of sustained VT spontaneously documented during patients\u2019 clinical course. Arrhythmogenic cardiomyopathy was defined according to the 2010 Task Force Criteria, and VT morphology according to the QRS pattern in V1. Overall, 882 (92.5%) patients displayed LBBB-VT alone and 72 (7.5%) RBBB-VT [alone in 42 (4.4%) or in combination with LBBB-VT in 30 (3.1%)]. Male sex prevalence was 79.3%, 88.1%, and 56.7% in the LBBB-VT, RBBB-VT, and LBBB\u2009+\u2009RBBB-VT groups, respectively (P\u2009=\u20090.007). First RBBB-VT occurred 5\u2009years after the first LBBB-VT (46.5\u2009\u00b1\u200914.4 vs 41.1\u2009\u00b1\u200915.8\u2009years, P\u2009=\u20090.011). An implanted cardioverter-defibrillator was more frequently implanted in the RBBB-VT (92.9%) and the LBBB\u2009+\u2009RBBB-VT groups (90%) than in the LBBB-VT group (68.1%) (P\u2009&amp;lt;\u20090.001). Mutations in PKP2 predominated in the LBBB-VT (65.2%) and the LBBB\u2009+\u2009RBBB-VT (41.7%) groups while DSP mutations predominated in the RBBB-VT group (45.5%). By multivariable analysis, female sex was associated with LBBB\u2009+\u2009RBBB-VT (P\u2009=\u20090.011) while DSP mutations were associated with RBBB-VT (P\u2009&amp;lt;\u20090.001). After a median follow-up of 103 (51\u2013185) months, death occurred in 106 (11.1%) patients with no intergroup difference (P\u2009=\u20090.176).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>RBBB-VT accounts for a significant proportion of sustained VTs in ACM. Sex and type of pathogenic mutations were associated with VT type, female sex with LBBB\u2009+\u2009RBBB-VT, and DSP mutation with RBBB-VT.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euab190","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T03:14:36Z","timestamp":1625627676000},"page":"285-295","source":"Crossref","is-referenced-by-count":14,"title":["The prevalence of left and right bundle branch block morphology ventricular tachycardia amongst patients with arrhythmogenic cardiomyopathy and sustained ventricular tachycardia: insights from the European Survey on Arrhythmogenic Cardiomyopathy"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7800-2546","authenticated-orcid":false,"given":"Bernard","family":"Belhassen","sequence":"first","affiliation":[{"name":"Heart Institute, Hadassah University Hospital, Kalman Ya'Akov Man Street, 9112001, Jerusalem, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7326-2656","authenticated-orcid":false,"given":"Mikael","family":"Laredo","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Institut de Cardiologie, 47-83 Boulevard de l'H\u00f4pital, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob W","family":"Roudijk","sequence":"additional","affiliation":[{"name":"Netherlands Heart Institute, Moreelsepark 1 3511 EP Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Peretto","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Zahavi","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel"},{"name":"Department of Anesthesiology, Sheba Medical Center, Tel Hashomer, 5265601, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srijita","family":"Sen-Chowdhry","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science University College London, 62 Huntley St, London WC1E 6DD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Badenco","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Institut de Cardiologie, 47-83 Boulevard de l'H\u00f4pital, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneline S J M","family":"Te Riele","sequence":"additional","affiliation":[{"name":"Netherlands Heart Institute, Moreelsepark 1 3511 EP Utrecht, The Netherlands"},{"name":"Department of Cardiology, University Medical Center, 62 Huntley St, London WC1E 6DD, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3303-8892","authenticated-orcid":false,"given":"Simone","family":"Sala","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Duthoit","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Institut de Cardiologie, 47-83 Boulevard de l'H\u00f4pital, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3854-6749","authenticated-orcid":false,"given":"J Peter","family":"van Tintelen","sequence":"additional","affiliation":[{"name":"Netherlands Heart Institute, Moreelsepark 1 3511 EP Utrecht, The Netherlands"},{"name":"Department of Genetics, University Medical Center, Moreelsepark 1 3511 EP Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Paglino","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Sellal","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Cardiologie, Centre Hospitalier Universitaire de Nancy, Vand\u0153uvre l\u00e8s-Nancy, Rue du Morvan, 54500 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3432-070X","authenticated-orcid":false,"given":"Alessio","family":"Gasperetti","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center Zurich, Hottingerstrasse 14 CH-8032 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Arbelo","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute, Hospital Clinic and IDIBAPS, Calle Villarroel, 170 08036 Barcelona, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Andorin","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, CHU de Nantes, Bd Jacques Monod \u2013 44800 Saint-Herblain, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Ninni","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille et Institut C\u0153ur-Poumon, CHRU, Boulevard du Professeur Jules Leclercq, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Rollin","sequence":"additional","affiliation":[{"name":"Cardiology, University Hospital Rangueil, 1 Avenue du Professeur Jean Poulh\u00e8s, 31400 Toulouse, 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The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Pierre","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, Centre Hospitalier Universitaire Trousseau, 2 Boulevard Tonnell\u00e9, 37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1304-6070","authenticated-orcid":false,"given":"Eyal","family":"Nof","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, P.O. 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