{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:37:10Z","timestamp":1787773030059,"version":"build-2784847793"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>We examined if a congenital long QT syndrome (cLQTS) diagnosis and severity of cLQTS disease manifestation was associated with increased risk of depression, anxiety, and all-cause mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>All patients with known cLQTS in Denmark were identified using nationwide registries and specialized inherited cardiac disease clinics (1994\u20132016) and followed for up to 3\u2009years after their cLQTS diagnosis. Risk factors for depression, anxiety, and all-cause mortality were determined using multivariable Cox proportional-hazards regression. An age- and sex-matched control population was identified (matching 1:4). Overall, 589 patients with cLQTS were identified of which 119\/589 (20.2%) developed depression or anxiety during follow-up compared with 302\/2356 (12.8%) from the control population (P\u2009&amp;lt;\u20090.001). Severity of cLQTS disease manifestation was identified for 324\/589 (55%) of patients with cLQTS; 162 were asymptomatic, 119 had ventricular tachycardia (VT)\/syncope, and 43 had aborted sudden cardiac death (aSCD). In multivariable models, patients with aSCD, VT\/syncope, or unspecified cLQTS disease manifestation had a higher risk of developing depression or anxiety compared with the control population (hazard ratio [HR]=2.4, 95% confidence interval [CI]: 1.1\u20135.1; HR\u2009=\u20091.9, 95% CI: 1.2\u20133.0; HR\u2009=\u20091.6, 95% CI: 1.1\u20132.3, respectively). Asymptomatic patients had similar risk of developing depression or anxiety as the control population (HR\u2009=\u20091.2, 95% CI: 0.8\u20131.9). During follow-up, 10\/589 (1.7%) patients with cLQTS died compared with 27\/2356 (1.1%) from the control population (P\u2009=\u20090.5). Furthermore, 4\/10 who died had developed depression or anxiety.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A severe cLQTS disease manifestation was associated with a greater risk of depression or anxiety. All-cause mortality for patients with cLQTS was low.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euab252","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T19:19:22Z","timestamp":1631733562000},"page":"620-629","source":"Crossref","is-referenced-by-count":11,"title":["Severity of congenital long QT syndrome disease manifestation and risk of depression, anxiety, and mortality: a nationwide study"],"prefix":"10.1093","volume":"24","author":[{"given":"Johanna","family":"Kr\u00f8ll","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1802-4302","authenticated-orcid":false,"given":"Henrik K","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Health, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Jespersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen K","family":"Kanters","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Laboratory of Experimental Cardiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Skov","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital of Southern Jutland, Aabenraa, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Laboratory of Experimental Cardiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Malta","family":"Westergaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil L","family":"Fosb\u00f8l","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus","family":"R\u00f8rth","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2892-6131","authenticated-orcid":false,"given":"Christian","family":"Torp-Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Investigation and Cardiology, Nordsjaellands Hospital, Hiller\u00f8d, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-7049","authenticated-orcid":false,"given":"Henning","family":"Bundgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3895-9316","authenticated-orcid":false,"given":"Jacob","family":"Tfelt-Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"},{"name":"Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E","family":"Weeke","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"2022040513525874200_euab252-B1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1192\/bjp.bp.115.171975","article-title":"Increased mortality among people with anxiety disorders: total population study","volume":"209","author":"Meier","year":"2016","journal-title":"Br J Psychiatry"},{"key":"2022040513525874200_euab252-B2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/clpt.2011.368","article-title":"Antidepressant use and risk of out-of-hospital cardiac arrest: a nationwide case-time-control study","volume":"92","author":"Weeke","year":"2012","journal-title":"Clin Pharmacol 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