{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T01:43:31Z","timestamp":1788227011961,"version":"build-2803163510"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic Inc.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Maurice Kahn Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To evaluate the benefit of speckle tracking radial strain imaging (STRSI)-guided left ventricular (LV) lead (LVL) positioning in cardiac resynchronization therapy (CRT) in patients (pts) with ischaemic cardiomyopathy with CRT indication.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We conducted a prospective randomized controlled trial. Patients were enrolled in nine centres with 2:1 randomization into two groups (guided vs. control). Patients underwent STRSI to identify the optimal LV position from six LV segments at midventricular level. Implantation via STRSI was attempted for recommended segment in the guided group only. Follow-up included echocardiography (6\u2009months) and clinical evaluation (6 and 12\u2009months). The primary endpoint was comparison % reduction in LV end-systolic volume at 6\u2009months with baseline. Secondary endpoints included hospitalizations for heart failure and death, and improvement in additional echocardiographic measurements and quality of life score. A total of 172 patients (115 guided vs. 57 control) were enrolled. In the guided group, 60% of the implanted LV leads were adjudicated to be successfully located at the recommended segment, whereas in the control group 44% reached the best STRSI determined segment. There was no difference between the groups in any of the primary or secondary endpoints at 6 and 12\u2009months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our findings suggest that echo-guided implantation of an LV lead using STRSI does not improve the clinical or echocardiographic response compared with conventional implantation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euab253","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T20:30:34Z","timestamp":1633033834000},"page":"835-844","source":"Crossref","is-referenced-by-count":13,"title":["Radial strain imaging-guided lead placement for improving response to cardiac resynchronization therapy in patients with ischaemic cardiomyopathy: the Raise CRT trial"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5706-0395","authenticated-orcid":false,"given":"Michael","family":"Glikson","sequence":"first","affiliation":[{"name":"Integrated Heart Centre, Shaare Zedek Medical Centre, Hebrew University, Jerusalem, Israel"},{"name":"Arrhythmia center, Sheba Medical Centre, Tel Aviv University, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9268-4766","authenticated-orcid":false,"given":"Roy","family":"Beinart","sequence":"additional","affiliation":[{"name":"Arrhythmia center, Sheba Medical Centre, Tel Aviv University, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Golovchiner","sequence":"additional","affiliation":[{"name":"Department of cardiology, Rabin MC, Tel Aviv University, Petah Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon Bar","family":"Sheshet","sequence":"additional","affiliation":[{"name":"Department of cardiology, Rabin MC, Tel Aviv University, Petah Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Swissa","sequence":"additional","affiliation":[{"name":"Department of cardiology, Kaplan MC, Hebrew University, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munther","family":"Bolous","sequence":"additional","affiliation":[{"name":"Department of cardiology, Rambam MC, Technion Institute, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Rosso","sequence":"additional","affiliation":[{"name":"Department of cardiology, Tel Aviv Souraski MC, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aharon","family":"Medina","sequence":"additional","affiliation":[{"name":"Integrated Heart Centre, Shaare Zedek Medical Centre, Hebrew University, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moti","family":"Haim","sequence":"additional","affiliation":[{"name":"Department of cardiology, Soroka MC, Ben Gurion University, Beer Sheba, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of cardiovascular medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Khalamaizer","sequence":"additional","affiliation":[{"name":"Department of cardiology, Barzilai MC, Ben Gurion University, Ashkelon, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomit","family":"Benzvi","sequence":"additional","affiliation":[{"name":"Israeli Centre for Cardiovascular Research, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of cardiovascular medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5806-3325","authenticated-orcid":false,"given":"Ilan","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Israeli Centre for Cardiovascular Research, Tel Hashomer, Israel"},{"name":"University of Rochester, Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Klempfner","sequence":"additional","affiliation":[{"name":"Israeli Centre for Cardiovascular Research, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Vaturi","sequence":"additional","affiliation":[{"name":"Arrhythmia center, Sheba Medical Centre, Tel Aviv University, Tel Hashomer, 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