{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:52:57Z","timestamp":1778817177014,"version":"3.51.4"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MicroPort Cardiac Rhythm Management"},{"name":"Engineering and Physical Sciences Research Council Centre for Medical Engineering","award":["WT203148\/Z\/16\/Z"],"award-info":[{"award-number":["WT203148\/Z\/16\/Z"]}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"EPSRC","doi-asserted-by":"publisher","award":["EP\/P01268X\/1"],"award-info":[{"award-number":["EP\/P01268X\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"EPSRC","doi-asserted-by":"publisher","award":["NS\/A000049\/1"],"award-info":[{"award-number":["NS\/A000049\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"EPSRC","doi-asserted-by":"publisher","award":["EP\/M012492\/1"],"award-info":[{"award-number":["EP\/M012492\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"BHF","doi-asserted-by":"publisher","award":["PG\/15\/91\/31812"],"award-info":[{"award-number":["PG\/15\/91\/31812"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"BHF","doi-asserted-by":"publisher","award":["FS\/18\/27\/33543"],"award-info":[{"award-number":["FS\/18\/27\/33543"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006662","name":"NIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT203148\/Z\/16\/Z"],"award-info":[{"award-number":["WT203148\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MicroPort and Medtronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To determine whether triventricular (TriV) pacing is feasible and improves CRT response compared to conventional biventricular (BiV) pacing in patients with left bundle branch block (LBBB) and intermediate QRS prolongation (120\u2013150\u2009ms).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Between October 2015 and November 2019, 99 patients were recruited from 11 UK centres. Ninety-five patients were randomized 1:1 to receive TriV or BiV pacing systems. The primary endpoint was feasibility of TriV pacing. Secondary endpoints assessed symptomatic and remodelling response to CRT. Baseline characteristics were balanced between groups. In the TriV group, 43\/46 (93.5%) patients underwent successful implantation vs. 47\/49 (95.9%) in the BiV group. Feasibility of maintaining CRT at 6\u2009months was similar in the TriV vs. BiV group (90.0% vs. 97.7%, P\u2009=\u20090.191). All-cause mortality was similar between TriV vs. BiV groups (4.3% vs. 8.2%, P\u2009=\u20090.678). There were no significant differences in echocardiographic LV volumes or clinical composite scores from baseline to 6-month follow-up between groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Implantation of two LV leads to deliver and maintain TriV pacing at 6 months is feasible without significant complications in the majority of patients. There was no evidence that TriV pacing improves CRT response or provides additional clinical benefit to patients with LBBB and intermediate QRS prolongation and cannot be recommended in this patient group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical trial registration number<\/jats:title>\n                  <jats:p>Clinicaltrials.gov: NCT02529410.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euab267","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T07:47:22Z","timestamp":1634370442000},"page":"796-806","source":"Crossref","is-referenced-by-count":7,"title":["Standard care vs. TRIVEntricular pacing in Heart Failure (STRIVE HF): a prospective multicentre randomized controlled\u00a0trial of triventricular pacing vs. conventional biventricular pacing in patients with heart failure and intermediate QRS left bundle branch block"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-5565","authenticated-orcid":false,"given":"Justin","family":"Gould","sequence":"first","affiliation":[{"name":"Guy\u2019s & St. Thomas\u2019 Hospitals, Westminster Bridge Road, London, SE1 7EH, UK"},{"name":"King\u2019s College London, Westminster Bridge Road, London, SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Claridge","sequence":"additional","affiliation":[{"name":"Guy\u2019s & St. Thomas\u2019 Hospitals, Westminster Bridge Road, London, SE1 7EH, UK"},{"name":"King\u2019s College London, Westminster Bridge Road, London, SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Jackson","sequence":"additional","affiliation":[{"name":"Guy\u2019s & St. Thomas\u2019 Hospitals, Westminster Bridge Road, London, SE1 7EH, UK"},{"name":"King\u2019s College London, Westminster Bridge Road, London, SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin J","family":"Sieniewicz","sequence":"additional","affiliation":[{"name":"Guy\u2019s & St. Thomas\u2019 Hospitals, Westminster Bridge Road, London, SE1 7EH, UK"},{"name":"King\u2019s College London, Westminster Bridge Road, London, SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baldeep S","family":"Sidhu","sequence":"additional","affiliation":[{"name":"Guy\u2019s & St. Thomas\u2019 Hospitals, Westminster Bridge Road, London, SE1 7EH, UK"},{"name":"King\u2019s College London, Westminster Bridge Road, London, SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley","family":"Porter","sequence":"additional","affiliation":[{"name":"Guy\u2019s & St. Thomas\u2019 Hospitals, Westminster Bridge Road, London, SE1 7EH, UK"},{"name":"King\u2019s College London, Westminster Bridge Road, London, SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2805-3043","authenticated-orcid":false,"given":"Mark K","family":"Elliott","sequence":"additional","affiliation":[{"name":"Guy\u2019s & St. Thomas\u2019 Hospitals, Westminster Bridge Road, London, SE1 7EH, UK"},{"name":"King\u2019s College London, Westminster Bridge Road, London, SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6140-068X","authenticated-orcid":false,"given":"Vishal","family":"Mehta","sequence":"additional","affiliation":[{"name":"Guy\u2019s & St. Thomas\u2019 Hospitals, Westminster Bridge Road, London, SE1 7EH, UK"},{"name":"King\u2019s College London, Westminster Bridge Road, London, SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4612-6982","authenticated-orcid":false,"given":"Steven","family":"Niederer","sequence":"additional","affiliation":[{"name":"King\u2019s College London, Westminster Bridge Road, London, SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humra","family":"Chadwick","sequence":"additional","affiliation":[{"name":"Guy\u2019s & St. Thomas\u2019 Hospitals, Westminster Bridge Road, London, SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Kamdar","sequence":"additional","affiliation":[{"name":"Croydon University Hospital, 530, London Road, Croydon, CR7 7YE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaumik","family":"Adhya","sequence":"additional","affiliation":[{"name":"Maritime Hospital, Windmill Road, Gillingham, Kent, ME7 5NY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil","family":"Patel","sequence":"additional","affiliation":[{"name":"Eastbourne District General Hospital, King's Drive, Eastbourne, East Sussex, BN21 2UD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoaib","family":"Hamid","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital, Stadium Road, London, SE18 4QH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic","family":"Rogers","sequence":"additional","affiliation":[{"name":"Northen General Hospital, Herries Road, Sheffield, South Yorkshire, S5 7AU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Nicolson","sequence":"additional","affiliation":[{"name":"Glenfield Hospital, Groby Road, Leicester, Leicestershire, LE3 9QP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheuk F","family":"Chan","sequence":"additional","affiliation":[{"name":"East Surrey Hospital, Canada Avenue, Redhill, RH1 5RH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Whinnett","sequence":"additional","affiliation":[{"name":"Hammersmith Hospital, Du Cane Road, London W12 0HS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Murgatroyd","sequence":"additional","affiliation":[{"name":"King\u2019s College Hospital, Denmark Hill, London, SE5 9RS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier D","family":"Lambiase","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, St Bartholomew's Hospital, West Smithfield, City of London, EC1A 7BE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Guy\u2019s & St. Thomas\u2019 Hospitals, Westminster Bridge Road, London, SE1 7EH, 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