{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:46:57Z","timestamp":1783676817488,"version":"3.55.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>This study aims to determine procedural characteristics, acute success rates, and medium-term outcomes of consecutive patients undergoing His bundle pacing (HBP); and learning curves of experienced electrophysiologists adopting HBP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Consecutive HBP patients at three hospitals were recruited. Clinical characteristics, acute procedural details, and medium-term outcomes were extracted from electronic medical records. Two hundred and thirty-three patients [mean age 74.6\u2009\u00b1\u200910.1\u2009years, 48% female, 68% narrow QRS, 71% normal left ventricular ejection fraction (LVEF), 55.8% atrioventricular block] underwent HBP. Acute procedural success was 81.1% (mean procedural and fluoroscopic times of 105.5\u2009\u00b1\u200936.5 and 13.8\u2009\u00b1\u20099.3\u2009min). Broad QRS was associated with lower HBP success (odds ratio 0.39, P\u2009=\u20090.02). Fluoroscopic and procedural times decreased and plateaued after 30\u201340 cases per operator. Implant HBP threshold was 1.3\u2009\u00b1\u20090.7\u2009V at 1.0\u2009\u00b1\u20090.2\u2009ms and R wave was 5.0\u2009\u00b1\u20093.9\u2009mV. During follow-up, loss of HBP occurred in a further 12.4% and 11.3% of patients experienced a \u22651\u2009V increase in HBP threshold. Five (2.6%) patients required HBP revision for pacing difficulties. About 8.6% of patients had a &amp;gt;50% decrease in R wave but lead revision for sensing issues was not necessary. On an intention to treat basis, 56.7% of patients in whom HBP was attempted had persisting HBP capture and thresholds of &amp;lt;2\u2009V.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Physicians adopting HBP should be cognizant of the learning curve and preferentially select non-dependent patients with normal QRS and LVEF, to minimize risk of lead revision. Further rises in HBP threshold may increase battery drain and need for reoperations, important considerations when choosing HBP for cardiac resynchronization therapy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euab278","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T11:08:50Z","timestamp":1635592130000},"page":"606-613","source":"Crossref","is-referenced-by-count":25,"title":["Adopting permanent His bundle pacing: learning curves and medium-term outcomes"],"prefix":"10.1093","volume":"24","author":[{"given":"Jhobeleen","family":"De Leon","sequence":"first","affiliation":[{"name":"Department of Cardiology, National University Heart Centre Singapore, 1E Kent Ridge Road, Singapore 119228, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swee-Chong","family":"Seow","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University Heart Centre Singapore, 1E Kent Ridge Road, Singapore 119228, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Boey","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Ng Teng Fong General Hospital, 1 Jurong East Street 21, Singapore 609606, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney","family":"Soh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University Heart Centre Singapore, 1E Kent Ridge Road, Singapore 119228, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University Heart Centre Singapore, 1E Kent Ridge Road, Singapore 119228, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiong Hiong","family":"Gan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Ng Teng Fong General Hospital, 1 Jurong East Street 21, Singapore 609606, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie Ying","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University Heart Centre Singapore, 1E Kent Ridge Road, Singapore 119228, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa Jie Ting","family":"Teo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Changi General Hospital, 2 Simei Street 3, Singapore 529889, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Changi General Hospital, 2 Simei Street 3, Singapore 529889, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vern Hsen","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Changi General Hospital, 2 Simei Street 3, Singapore 529889, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6295-4905","authenticated-orcid":false,"given":"Pipin","family":"Kojodjojo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University Heart Centre Singapore, 1E Kent Ridge Road, Singapore 119228, Singapore"},{"name":"Division of Cardiology, Ng Teng Fong General Hospital, 1 Jurong East Street 21, Singapore 609606, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,25]]},"reference":[{"key":"2022040513530489800_euab278-B1","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1161\/01.CIR.0000072769.17295.B1","article-title":"Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node 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