{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:54:32Z","timestamp":1790913272894,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.nationalarchives.gov.uk\/doc\/open-government-licence\/version\/3\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Myotonic dystrophy type 1 (DM1) predisposes to the development of life-threatening arrhythmias and sudden cardiac death. Our study aimed to evaluate the prognostic value of programmed ventricular stimulation (PVS) in DM1 patients with conduction system disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Arrhythmic CArdiac DEath in MYotonic dystrophy type 1 patients (ACADEMY 1) is a double-arm non-randomized interventional prospective study. Myotonic dystrophy type 1 patients with permanent cardiac pacing indication were eligible for the inclusion. The study population underwent to pacemaker (PM) or implantable cardioverter-defibrillator (ICD) implantation according to the inducibility of ventricular tachyarrhythmias at PVS. Primary endpoint of the study was a composite of appropriate ICD therapy and cardiac arrhythmic death. The secondary study endpoint was all-cause mortality. Seventy-two adult-onset DM1 patients (51 \u00b1 12 years; 39 male) were enrolled in the study. A ventricular tachyarrhythmia was induced in 25 patients (34.7%) at PVS (PVS+) who underwent dual chambers ICD implantation. The remaining 47 patients (65.3%) without inducible ventricular tachyarrhythmia (PVS\u2212) were treated with dual-chamber PM. During an average observation period of 44.7 \u00b1 10.2 months, nine patients (12.5%) met the primary endpoint, four in the ICD group (16%) and five (10.6%) in the PM group. Thirteen patients died (18.5%), 2 in the ICD group (8%) and 11 in PM group (23.4%). The Kaplan\u2013Meier analysis did not show a significantly different risk of both primary and secondary endpoint event rates between the two groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The inducibility of ventricular tachyarrhythmias has shown a limited value in the arrhythmic risk stratification among DM1 patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euab282","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T04:39:43Z","timestamp":1636173583000},"page":"1148-1155","source":"Crossref","is-referenced-by-count":11,"title":["Arrhythmic CArdiac DEath in MYotonic dystrophy type 1 patients (ACADEMY 1) study: the predictive role of programmed ventricular stimulation"],"prefix":"10.1093","volume":"24","author":[{"given":"Vincenzo","family":"Russo","sequence":"first","affiliation":[{"name":"Cardiology Unit, Department of Medical Translational Sciences, University of Campania \u2018Luigi Vanvitelli\u2019, Monaldi Hospital , Naples 80131 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5654-4686","authenticated-orcid":false,"given":"Andrea Antonio","family":"Papa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Monaldi Hospital , Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Rago","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Monaldi Hospital , Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Ciardiello","sequence":"additional","affiliation":[{"name":"Clinical Affairs, HT MED , Pozzuoli , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Martino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Policlinico Casilino Hospital , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Stazi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Policlinico Casilino Hospital , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3590-6983","authenticated-orcid":false,"given":"Paolo","family":"Golino","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Medical Translational Sciences, University of Campania \u2018Luigi Vanvitelli\u2019, Monaldi Hospital , Naples 80131 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Cal\u00f2","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Policlinico Casilino Hospital , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1776-8449","authenticated-orcid":false,"given":"Gerardo","family":"Nigro","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Medical Translational Sciences, University of Campania \u2018Luigi Vanvitelli\u2019, Monaldi Hospital , Naples 80131 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"2022072112085169100_euab282-B1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1136\/heart.88.6.665","article-title":"Myotonic dystrophy and the heart","volume":"88","author":"Pelargonio","year":"2002","journal-title":"Heart"},{"key":"2022072112085169100_euab282-B2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ijcard.2011.08.037","article-title":"Cardiac manifestations of myotonic dystrophy type 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