{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T05:46:56Z","timestamp":1768715216106,"version":"3.49.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100009542","name":"Limburg Sterk Merk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009542","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Province of Limburg"},{"DOI":"10.13039\/501100011878","name":"Flemish Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011878","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009550","name":"Hasselt University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018216","name":"Ziekenhuis Oost-Limburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018216","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jessa Hospital"},{"name":"Fund for Scientific Research Flanders","award":["FWO 1S83221N"],"award-info":[{"award-number":["FWO 1S83221N"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The aim of this study is to evaluate whether the MADIT-ICD benefit score can predict who benefits most from the addition of implantable cardioverter-defibrillator (ICD) to cardiac resynchronization therapy (CRT) in real-world patients with heart failure with reduced ejection fraction (HFrEF) and to compare this with selection according to a multidisciplinary expert centre approach.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Consecutive HFrEF patients who received a CRT for a guideline indication at a tertiary care hospital (Ziekenhuis Oost-Limburg, Genk, Belgium) between October 2008 and September 2016, were retrospectively evaluated. The MADIT-ICD benefit groups (low, intermediate, and high) were compared with the current multidisciplinary expert centre approach. Endpoints were (i) sustained ventricular tachycardia (VT) or ventricular fibrillation (VF) and (ii) non-arrhythmic mortality. Of the 475 included patients, 165 (34.7%) were in the lowest, 220 (46.3%) in the intermediate, and 90 (19.0%) in the highest benefit group. After a median follow-up of 34 months, VT\/VF occurred in 3 (1.8%) patients in the lowest, 9 (4.1%) in the intermediate, and 13 (14.4%) in the highest benefit group (P &amp;lt; 0.001). Vice versa, non-arrhythmic death occurred in 32 (19.4%) in the lowest, 32 (14.6%) in the intermediate, and 3 (3.3%) in the highest benefit group (P = 0.002). The predictive power for ICD benefit was comparable between expert multidisciplinary judgement and the MADIT-ICD benefit score: Uno\u2019s C-statistic 0.69 vs. 0.69 (P = 0.936) for VT\/VF and 0.62 vs. 0.60 (P = 0.790) for non-arrhythmic mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The MADIT-ICD benefit score can identify who benefits most from CRT-D and is comparable with multidisciplinary judgement in a CRT expert centre.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euac039","type":"journal-article","created":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T12:08:47Z","timestamp":1646482127000},"page":"1276-1283","source":"Crossref","is-referenced-by-count":12,"title":["The MADIT-ICD benefit score helps to select implantable cardioverter-defibrillator candidates in cardiac resynchronization therapy"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4605-3450","authenticated-orcid":false,"given":"Jeroen","family":"Dauw","sequence":"first","affiliation":[{"name":"Department of Cardiology, Ziekenhuis Oost-Limburg , Schiepse Bos 6, 3600 Genk , Belgium"},{"name":"UHasselt, Doctoral School for Medicine and Life Sciences, LCRC , Diepenbeek , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6036-2113","authenticated-orcid":false,"given":"Pieter","family":"Martens","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ziekenhuis Oost-Limburg , Schiepse Bos 6, 3600 Genk , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7325-7734","authenticated-orcid":false,"given":"Petra","family":"Nijst","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ziekenhuis Oost-Limburg , Schiepse Bos 6, 3600 Genk , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Meekers","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ziekenhuis Oost-Limburg , Schiepse Bos 6, 3600 Genk , Belgium"},{"name":"UHasselt, Doctoral School for Medicine and Life Sciences, LCRC , Diepenbeek , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2215-8680","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Deferm","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ziekenhuis Oost-Limburg , Schiepse Bos 6, 3600 Genk , Belgium"},{"name":"UHasselt, Doctoral School for Medicine and Life Sciences, LCRC , Diepenbeek , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9169-265X","authenticated-orcid":false,"given":"Henri","family":"Gruwez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ziekenhuis Oost-Limburg , Schiepse Bos 6, 3600 Genk , Belgium"},{"name":"UHasselt, Doctoral School for Medicine and Life Sciences, LCRC , Diepenbeek , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximo","family":"Rivero-Ayerza","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ziekenhuis Oost-Limburg , Schiepse Bos 6, 3600 Genk , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Van Herendael","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ziekenhuis Oost-Limburg , Schiepse Bos 6, 3600 Genk , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Pison","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ziekenhuis Oost-Limburg , Schiepse Bos 6, 3600 Genk , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Nuyens","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ziekenhuis Oost-Limburg , Schiepse Bos 6, 3600 Genk , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0802-9508","authenticated-orcid":false,"given":"Matthias","family":"Dupont","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ziekenhuis Oost-Limburg , Schiepse Bos 6, 3600 Genk , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9995-8590","authenticated-orcid":false,"given":"Wilfried","family":"Mullens","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ziekenhuis Oost-Limburg , Schiepse Bos 6, 3600 Genk , Belgium"},{"name":"UHasselt, Biomedical Research Institute, Faculty of Medicine and Life Sciences, LCRC , Diepenbeek , 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