{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T06:22:16Z","timestamp":1792995736355,"version":"4.5.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Catheter ablation for atrial fibrillation (AF) using thermal energy can cause collateral damage. Pulsed field ablation (PFA) is a novel non-thermal energy source. Few small clinical studies have been published. We report on the first \u2018real-world\u2019 experience with pulmonary vein isolation (PVI) using PFA for paroxysmal AF (PAF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Pre- and post-ablation, phrenic nerve function was assessed. After high-density left atrial (LA) bipolar voltage mapping, all PVs were individually isolated using a 13\u2005Fr steerable sheath and a pentaspline PFA over-the-wire catheter. After ablation, bipolar voltage mapping was repeated to assess lesion formation. In 30 PAF patients (mean 63 years; 53% female), uncomplicated PFA was performed, with all PVs acutely isolated. The median procedure time was 116\u2005min. The median PFA catheter LA dwell time was 29\u2005min. The median fluoroscopy time was 26\u2005min. In one patient with roof-dependent flutter, a roof line was intentionally created. In two patients, unintentional bidirectional mitral isthmus block was created. There was no phrenic nerve or oesophageal damage. In one patient, pericardial drainage after cardiac tamponade was performed. In-hospital stay and 30-day follow-up were uneventful. After 90 days, 97% of patients were in sinus rhythm.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>PVI using PFA for PAF in a \u2018real-world\u2019 setting appears to be safe and feasible in this small patient cohort. Procedure times are homogeneous, and LA dwell time is short. Atrial ablation lines can easily be created. Unintentional ablation of atrial tissue can occur, accurate catheter alignment to the PV ostium and axis should be ensured.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euac041","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T20:11:16Z","timestamp":1646856676000},"page":"1084-1092","source":"Crossref","is-referenced-by-count":46,"title":["First experience with pulsed field ablation as routine treatment for paroxysmal atrial fibrillation"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2116-1690","authenticated-orcid":false,"given":"Anna","family":"F\u00fcting","sequence":"first","affiliation":[{"name":"Department of Electrophysiology, Alfried Krupp Hospital , Essen , Germany"},{"name":"Department of Medicine, Witten\/Herdecke University , Witten , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7385-2691","authenticated-orcid":false,"given":"Nico","family":"Reinsch","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Alfried Krupp Hospital , Essen , Germany"},{"name":"Department of Medicine, Witten\/Herdecke University , Witten , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"H\u00f6wel","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Alfried Krupp Hospital , Essen , Germany"},{"name":"Department of Medicine, Witten\/Herdecke University , Witten , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenny","family":"Brokkaar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Witten\/Herdecke University , Witten , Germany"},{"name":"Department of Pulmonology, Alfried Krupp Hospital , Essen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Rahe","sequence":"additional","affiliation":[{"name":"Department of Medicine, Witten\/Herdecke University , Witten , Germany"},{"name":"Department of Gastroenterology, Alfried Krupp Hospital , Alfried-Krupp-Str. 21, 45131 Essen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2075-8113","authenticated-orcid":false,"given":"Kars","family":"Neven","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Alfried Krupp Hospital , Essen , Germany"},{"name":"Department of Medicine, Witten\/Herdecke University , Witten , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"2022072112085650500_euac041-B1","first-page":"373","article-title":"ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC","volume":"2021","author":"Hindricks","year":"2020","journal-title":"Eur Heart J"},{"key":"2022072112085650500_euac041-B2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/jce.12308","article-title":"Esophago-pericardial fistula complicating atrial fibrillation ablation using a novel irrigated radiofrequency multipolar ablation catheter","volume":"25","author":"Deneke","year":"2014","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2022072112085650500_euac041-B3","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1161\/CIRCEP.109.922930","article-title":"Fatal end of a safety algorithm for pulmonary vein isolation with use of high-intensity focused ultrasound","volume":"3","author":"Neven","year":"2010","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2022072112085650500_euac041-B4","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1540-8167.2010.01863.x","article-title":"Feasibility of electroporation for the creation of pulmonary vein ostial lesions","volume":"22","author":"Wittkampf","year":"2011","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2022072112085650500_euac041-B5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/europace\/eus171","article-title":"Minimal coronary artery damage by myocardial electroporation ablation","volume":"15","author":"du Pre","year":"2013","journal-title":"Europace"},{"key":"2022072112085650500_euac041-B6","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1161\/CIRCEP.113.001111","article-title":"Pulmonary vein stenosis after catheter ablation: electroporation versus radiofrequency","volume":"7","author":"van Driel","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2022072112085650500_euac041-B7","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1016\/j.hrthm.2015.05.012","article-title":"Low vulnerability of the right phrenic nerve to electroporation ablation","volume":"12","author":"van Driel","year":"2015","journal-title":"Heart Rhythm"},{"key":"2022072112085650500_euac041-B8","doi-asserted-by":"crossref","first-page":"e004672","DOI":"10.1161\/CIRCEP.116.004672","article-title":"Acute and long-term effects of full-power electroporation ablation directly on the porcine esophagus","volume":"10","author":"Neven","year":"2017","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2022072112085650500_euac041-B9","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.hrthm.2021.02.015","article-title":"Absence of (sub-)acute cerebral events or lesions after electroporation ablation in the left-sided canine heart","volume":"18","author":"Neven","year":"2021","journal-title":"Heart Rhythm"},{"key":"2022072112085650500_euac041-B10","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.jacep.2018.04.005","article-title":"Ablation of atrial fibrillation with pulsed electric fields: An ultra-rapid, tissue-selective modality for cardiac ablation","volume":"4","author":"Reddy","year":"2018","journal-title":"JACC Clin Electrophysiol"},{"key":"2022072112085650500_euac041-B11","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jacc.2019.04.021","article-title":"Pulsed field ablation for pulmonary vein isolation in atrial fibrillation","volume":"74","author":"Reddy","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2022072112085650500_euac041-B12","doi-asserted-by":"crossref","first-page":"e008192","DOI":"10.1161\/CIRCEP.119.008192","article-title":"Pulmonary Vein Isolation With Single Pulse Irreversible Electroporation: A First in Human Study in 10 Patients With Atrial Fibrillation","volume":"13","author":"Loh","year":"2020","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2022072112085650500_euac041-B13","doi-asserted-by":"crossref","first-page":"516","DOI":"10.5603\/CJ.a2013.0153","article-title":"Biomarkers of myocardial injury with different energy sources for atrial fibrillation catheter ablation","volume":"21","author":"Casella","year":"2014","journal-title":"Cardiol J"}],"container-title":["EP Europace"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/24\/7\/1084\/45041669\/euac041.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/24\/7\/1084\/45041669\/euac041.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T12:11:06Z","timestamp":1658405466000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/24\/7\/1084\/6581486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,6]]},"references-count":13,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,5,6]]},"published-print":{"date-parts":[[2022,7,21]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euac041","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,1]]},"published":{"date-parts":[[2022,5,6]]}}}