{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:19:36Z","timestamp":1787008776507,"version":"build-2736575974"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"University of Minnesota Medical School"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Inappropriate sinus tachycardia (IST) is a syndrome characterized by an elevated sinus rate unassociated with known physiological, pathological, or pharmacological causes. Despite published consensus documents, IST definitions appear to vary in the literature. In this study, we reviewed IST publications to evaluate IST definition variability and ascertain the degree to which consensus definitions are being adopted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>English-language articles in PubMed, Ovid MEDLINE, Ovid Embase, and Google Scholar published from 1 January 1970 to 1 June 2021 with the title terms \u2018inappropriate sinus tachycardia,\u2019 \u2018non-paroxysmal sinus tachycardia,\u2019 or \u2018permanent sinus tachycardia\u2019 were searched. In each, the IST definition used, qualifying characteristics, and publications cited to support each definition were recorded. We identified 138 publications meeting the search criteria. Inappropriate sinus tachycardia definitions were provided in 114 of 138 articles (83%). A majority of definitions (92\/114, 81%) used distinct heart rate (HR) thresholds. Among these, the most common threshold was \u2265100 beats per minute (BPM) (75\/92, 82%), mainly measured at rest (54\/92, 59%). Most definitions (47\/92, 51%) included a second criterion to qualify for IST; these were most often an HR threshold of 90\u2005BPM measured over 24\u2005h by ambulatory electrocardiogram (37\/47, 79%). Diagnosis of exclusion was a common criterion (75\/92, 82%) but symptom status was not (41\/92, 45%). The 2015 Heart Rhythm Society IST consensus was commonly cited but adopted in only 37% of definitions published after 2015.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Inappropriate sinus tachycardia definitions in current literature are inconsistent, and professional society consensus IST definitions have, to date, had limited impact.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euac057","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T15:10:17Z","timestamp":1650640217000},"page":"1655-1664","source":"Crossref","is-referenced-by-count":8,"title":["Inappropriate sinus tachycardia: an examination of existing definitions"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8692-6768","authenticated-orcid":false,"given":"Cody R","family":"Hou","sequence":"first","affiliation":[{"name":"Cardiac Arrhythmia Center, Cardiovascular Division, University of Minnesota , Mail Code 508, 420 Delaware St SE, Minneapolis, MN 55455 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6044-045X","authenticated-orcid":false,"given":"Brian","family":"Olshansky","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Iowa , Iowa City, IA 52242 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cortez","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, University of California Davis Medical Center , Sacramento, CA 95616 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Duval","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center, Cardiovascular Division, University of Minnesota , Mail Code 508, 420 Delaware St SE, Minneapolis, MN 55455 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8511-6920","authenticated-orcid":false,"given":"David G","family":"Benditt","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center, Cardiovascular Division, University of Minnesota , Mail Code 508, 420 Delaware St SE, Minneapolis, MN 55455 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,19]]},"reference":[{"key":"2022101319385576800_euac057-B1","doi-asserted-by":"crossref","first-page":"702","DOI":"10.7326\/0003-4819-91-5-702","article-title":"Chronic nonparoxysmal sinus tachycardia in otherwise healthy persons","volume":"91","author":"Bauernfeind","year":"1979","journal-title":"Ann Intern Med"},{"key":"2022101319385576800_euac057-B2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.eupc.2004.12.007","article-title":"Prevalence, 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