{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:44:34Z","timestamp":1788284674262,"version":"build-2803163510"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>Cardiac sympathetic denervation (CSD) has been introduced as a bailout therapy in patients with structural heart disease and refractory ventricular arrhythmias (VAs), but available data are scarce. Purpose of this study was to estimate immediate results, complications, and mid-term outcomes of CSD following recurrent VA after catheter ablation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Adult patients who underwent CSD in the Heart Center Leipzig from March 2017 to February 2021 were retrospectively analysed. Follow-up (FU) was executed via implantable cardioverter defibrillator (ICD) interrogation, telephone interviews, and reviewing medical records. Twenty-one patients (age 63.7 \u00b1 14.4 years, all men, 71.4% non-ischaemic cardiomyopathy, left ventricular ejection fraction 31.6 \u00b1 12.6%) received CSD via video-assisted thoracoscopic surgery (90.5% bilateral, 9.5% left-sided only). Indication for CSD was monomorphic ventricular tachycardia in 76.2% and ventricular fibrillation in 23.8 with 71.4% of patients presenting with electrical storm before index hospitalization. Procedure-related major complications occurred in 9.5% of patients. In-hospital adverse events not related to surgery were common (28.6%) and two patients died during the index hospital stay. During FU (mean duration 9.1 \u00b1 6.5 months), five more patients died. Of the remaining patients, 38.5 and 76.9% were free from any VA or ICD shocks, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The CSD showed additional moderate efficacy to suppress VAs, when performed as a bailout therapy after previously unsuccessful catheter ablation. At 9 months, it was associated with freedom of ICD shocks in two-thirds of patients. In a population with many comorbidities, the rate of CSD-related complications was acceptable, although there was an overall high risk of procedure unrelated adverse events and death.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euac078","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T11:20:06Z","timestamp":1652181606000},"page":"1800-1808","source":"Crossref","is-referenced-by-count":20,"title":["Outcomes following cardiac sympathetic denervation in patients with structural heart disease and refractory ventricular arrhythmia"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3759-3052","authenticated-orcid":false,"given":"Sebastian","family":"K\u00f6nig","sequence":"first","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig at University of Leipzig , Str\u00fcmpellstra\u00dfe 39, Leipzig 04289 , Germany"},{"name":"Leipzig Heart Institute , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schr\u00f6ter","sequence":"additional","affiliation":[{"name":"Heart Center Leipzig at University of Leipzig, Department of Cardiac Surgery , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1046-1364","authenticated-orcid":false,"given":"Michael A","family":"Borger","sequence":"additional","affiliation":[{"name":"Heart Center Leipzig at University of Leipzig, Department of Cardiac Surgery , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livio","family":"Bertagnolli","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig at University of Leipzig , Str\u00fcmpellstra\u00dfe 39, Leipzig 04289 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios","family":"Nedios","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig at University of Leipzig , Str\u00fcmpellstra\u00dfe 39, Leipzig 04289 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Darma","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig at University of Leipzig , Str\u00fcmpellstra\u00dfe 39, Leipzig 04289 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Hindricks","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig at University of Leipzig , Str\u00fcmpellstra\u00dfe 39, Leipzig 04289 , Germany"},{"name":"Leipzig Heart Institute , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig at University of Leipzig , Str\u00fcmpellstra\u00dfe 39, Leipzig 04289 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borislav","family":"Dinov","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig at University of Leipzig , Str\u00fcmpellstra\u00dfe 39, Leipzig 04289 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,19]]},"reference":[{"key":"2022112218073696500_euac078-B1","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1093\/europace\/euz332","article-title":"2019 HRS\/EHRA\/APHRS\/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias: executive summary","volume":"22","author":"Cronin","year":"2020","journal-title":"Europace"},{"key":"2022112218073696500_euac078-B2","first-page":"1601","article-title":"2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac 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