{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:09:24Z","timestamp":1788847764875,"version":"build-2803163510"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Trust Stiftelsen Dam","award":["2016\/FO82036"],"award-info":[{"award-number":["2016\/FO82036"]}]},{"name":"Trust Stiftelsen Dam","award":["296908"],"award-info":[{"award-number":["296908"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Studies with implantable cardiac monitors (ICMs) show that one-third of patients with cryptogenic stroke\/transient ischaemic attack (TIA) have episodes of subclinical atrial fibrillation (SCAF) and benefit switching from antiplatelet- to anticoagulant therapy. However, ICMs are costly and resource demanding. We aimed to build a score based on participant\u2019s baseline characteristics that could assess individual risk of SCAF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In a prospective study, 236 eligible patients with a final diagnosis of cryptogenic stroke\/TIA had an ICM implantated during the index hospitalization. Pre-specified evaluated variables were: CHA2DS2-VASc, P-wave duration, P-wave morphology, premature atrial beats (PAC)\/24\u2005h, supraventricular tachycardia\/24\u2005h, left atrial end-systolic volume index (LAVI), Troponin-T, NT-proBNP, and D-dimer. SCAF was detected in 84 patients (36%). All pre-specified variables were significantly associated with SCAF detection in univariate analysis. P-wave duration, followed by PAC\/24\u2005h, NT-proBNP, and LAVI, had the largest ratio of SCAF prevalence between its upper and lower quartiles (3.3, vs. 3.2, vs. 3.1 vs. 2.8, respectively). However, in a multivariate analysis, only PAC\/24t, P-wave duration, P-wave morphology, and LAVIs remained significant predictors and were included in the PROACTIA score. Subclinical atrial fibrillation prevalence was 75% in the highest vs. 10% in the lowest quartile of the PROACTIA score with a 10-fold higher number of patients with an atrial fibrillation burden &amp;gt;6\u2005h in the highest vs. the lowest quartile.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The PROACTIA score can identify patients with cryptogenic stroke\/TIA at risk of subsequent SCAF detection. The large difference in SCAF prevalence between groups may provide a basis for future tailored therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical trial registration<\/jats:title>\n                  <jats:p>Clinical Trial Registration: ClinicalTrials.gov; NCT02725944.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euac092","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T12:29:31Z","timestamp":1657628971000},"page":"1881-1888","source":"Crossref","is-referenced-by-count":32,"title":["Prediction of occult atrial fibrillation in patients after cryptogenic stroke and transient ischaemic attack: PROACTIA"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0534-1694","authenticated-orcid":false,"given":"Loreta","family":"Skrebelyte-Str\u00f8m","sequence":"first","affiliation":[{"name":"Akershus University Hospital , L\u00f8renskog , Norway"},{"name":"University of Oslo , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole Morten","family":"R\u00f8nning","sequence":"additional","affiliation":[{"name":"Akershus University Hospital , L\u00f8renskog , Norway"},{"name":"University of Oslo , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik A","family":"Dahl","sequence":"additional","affiliation":[{"name":"Akershus University Hospital , L\u00f8renskog , Norway"},{"name":"Norwegian Computing Center , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4265-3598","authenticated-orcid":false,"given":"Kjetil","family":"Steine","sequence":"additional","affiliation":[{"name":"Akershus University Hospital , L\u00f8renskog , Norway"},{"name":"University of Oslo , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Kjekshus","sequence":"additional","affiliation":[{"name":"Akershus University Hospital , L\u00f8renskog , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,12]]},"reference":[{"key":"2022120921222549100_euac092-B1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1161\/CIRCRESAHA.116.308447","article-title":"Cryptogenic stroke: research and practice","volume":"120","author":"Yaghi","year":"2017","journal-title":"Circ Res"},{"key":"2022120921222549100_euac092-B2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.5853\/jos.2019.01067","article-title":"Duration of implantable cardiac monitoring and detection of atrial fibrillation in ischemic stroke patients: a systematic review and meta-analysis","volume":"21","author":"Tsivgoulis","year":"2019","journal-title":"J Stroke"},{"key":"2022120921222549100_euac092-B3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1161\/CIRCEP.109.877852","article-title":"Performance of a new leadless implantable cardiac monitor in detecting and quantifying atrial fibrillation: results of the xpect trial","volume":"3","author":"Hindricks","year":"2010","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2022120921222549100_euac092-B4","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.amjcard.2015.06.012","article-title":"A comparison of atrial fibrillation monitoring strategies after cryptogenic stroke (from the cryptogenic stroke and underlying af trial)","volume":"116","author":"Choe","year":"2015","journal-title":"Am J Cardiol"},{"key":"2022120921222549100_euac092-B5","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/ana.25886","article-title":"Implantable cardiac monitoring in the secondary prevention of cryptogenic stroke","volume":"88","author":"Triantafyllou","year":"2020","journal-title":"Ann Neurol"},{"key":"2022120921222549100_euac092-B6","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S1474-4422(13)70310-7","article-title":"Embolic strokes of undetermined source: the case for a new clinical construct","volume":"13","author":"Hart","year":"2014","journal-title":"Lancet Neurol"},{"key":"2022120921222549100_euac092-B7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of subtype of acute ischemic stroke. 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