{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:08:57Z","timestamp":1787843337173,"version":"build-2784847793"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>Evaluate the novel PolarX Cryoballoon in atrial fibrillation (AF) catheter ablation through a propensity-matched comparison with the Arctic Front Advance (AFA). The aim was also to identify cryoablation metrics that are predictive of successful pulmonary vein isolation (PVI) with the PolarX Cryoballoon.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This prospective multi-centre study included patients that underwent cryoablation for AF. All patients underwent PVI with reconnection assessed after a 30-min waiting period and adenosine. Safety, efficacy, and cryoablation metrics were compared between PolarX and a propensity-matched AFA cohort. Seventy patients were included with 278 veins treated. In total, 359 cryoablations were performed (1.3\u2009\u00b1\u20090.6 per vein) to achieve initial PVI with 205 (73.7%) veins isolating with a single cryoablation. Independent predictors for achieving initial PVI included temperature at 30\u2005s [odds ratio (OR) 1.26; P\u2009=\u20090.003] and time to reach \u221240\u00b0C (OR 1.88; P\u2009&amp;lt;\u20090.001) with an optimal cut-off of \u2264\u221238.5\u00b0C at 30\u2005s [area under the curve (AUC) 0.79; P\u2009&amp;lt;\u20090.001] and \u2264\u221240\u00b0C at \u226432.5\u2005s (AUC 0.77; P\u2009&amp;lt;\u20090.001), respectively. Of the 278 veins, 46 (16.5%) veins showed acute reconnection. Temperature at 30\u2005s (\u2264\u221239.5\u00b0C, OR 1.24; P\u2009=\u20090.002), nadir temperature (\u2264\u221253.5\u00b0C, OR 1.35; P\u2009=\u20090.003), and time to isolation (\u226438.0\u2005s, OR 1.18; P\u2009=\u20090.009) were independent predictors of sustained PVI. Combining two of these three targets was associated with reconnection in only 2\u20135% of PVs. Efficacy and safety of the PolarX Cryoballoon were comparable to AFA Cryoballoon, however, cryoablation metrics were significantly different.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The PolarX Cryoballoon has a different cryoablation profile to AFA Cryoballoon. Prospective testing of these proposed targets in large outcomes studies is required.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euac100","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T17:32:05Z","timestamp":1656005525000},"page":"1420-1429","source":"Crossref","is-referenced-by-count":21,"title":["PolarX Cryoballoon metrics predicting successful pulmonary vein isolation: targets for ablation of atrial fibrillation"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0081-5739","authenticated-orcid":false,"given":"Shohreh","family":"Honarbakhsh","sequence":"first","affiliation":[{"name":"The Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust , W. Smithfield, EC1A 7BE London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J","family":"Earley","sequence":"additional","affiliation":[{"name":"The Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust , W. Smithfield, EC1A 7BE London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire A","family":"Martin","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital , Cambridge , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Creta","sequence":"additional","affiliation":[{"name":"The Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust , W. Smithfield, EC1A 7BE London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afzal","family":"Sohaib","sequence":"additional","affiliation":[{"name":"The Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust , W. Smithfield, EC1A 7BE London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Ang","sequence":"additional","affiliation":[{"name":"The Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust , W. Smithfield, EC1A 7BE London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Butcher","sequence":"additional","affiliation":[{"name":"The Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust , W. Smithfield, EC1A 7BE London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H","family":"Waddingham","sequence":"additional","affiliation":[{"name":"The Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust , W. Smithfield, EC1A 7BE London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehul","family":"Dhinoja","sequence":"additional","affiliation":[{"name":"The Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust , W. Smithfield, EC1A 7BE London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lim","sequence":"additional","affiliation":[{"name":"Norfolk and Norwich University Hospitals NHS Foundation Trust , Norwich , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil T","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Circulatory Health Research Group, Medical Technology Research Centre, School of Medicine, Anglia Ruskin University , CM1 1SQ Chelmsford , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Providencia","sequence":"additional","affiliation":[{"name":"The Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust , W. Smithfield, EC1A 7BE London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayabharathy","family":"Kanthasamy","sequence":"additional","affiliation":[{"name":"The Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust , W. Smithfield, EC1A 7BE London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1495-090X","authenticated-orcid":false,"given":"Simon","family":"Sporton","sequence":"additional","affiliation":[{"name":"The Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust , W. Smithfield, EC1A 7BE London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Chow","sequence":"additional","affiliation":[{"name":"The Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust , W. Smithfield, EC1A 7BE London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9055-9267","authenticated-orcid":false,"given":"Pier D","family":"Lambiase","sequence":"additional","affiliation":[{"name":"The Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust , W. Smithfield, EC1A 7BE London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0621-8241","authenticated-orcid":false,"given":"Richard J","family":"Schilling","sequence":"additional","affiliation":[{"name":"The Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust , W. Smithfield, EC1A 7BE London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm C","family":"Finlay","sequence":"additional","affiliation":[{"name":"The Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust , W. Smithfield, EC1A 7BE London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross J","family":"Hunter","sequence":"additional","affiliation":[{"name":"The Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust , W. 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