{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:55:44Z","timestamp":1790913344532,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004243","name":"Prinses Beatrix Spierfonds","doi-asserted-by":"crossref","award":["W.OR15-25"],"award-info":[{"award-number":["W.OR15-25"]}],"id":[{"id":"10.13039\/501100004243","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004243","name":"Prinses Beatrix Spierfonds","doi-asserted-by":"crossref","award":["W.TR19-01)"],"award-info":[{"award-number":["W.TR19-01)"]}],"id":[{"id":"10.13039\/501100004243","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To evaluate the clinical effectiveness of routine 24 h Holter monitoring to screen for conduction disturbances and arrhythmias in patients with myotonic dystrophy type 1 (DM1).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A retrospective two-centre study was conducted including DM1-affected individuals undergoing routine cardiac screening with at least one 24 h Holter monitoring between January 2010 and December 2020. For each individual, the following data were collected: Holter results, results of electrocardiograms (ECGs) performed at the same year as Holter monitoring, presence of cardiac complaints, and neuromuscular status. Holter findings were compared with the results of cardiac screening (ECG + history taking) performed at the same year. Cardiac conduction abnormalities and\/or arrhythmias that would have remained undiagnosed based on history taking and ECG alone were considered de novo findings. A total 235 genetically confirmed DM1 patients were included. Abnormal Holter results were discovered in 126 (54%) patients after a mean follow-up of 64 \u00b1 28 months in which an average of 3 \u00b1 1 Holter recordings per patient was performed. Abnormalities upon Holter mainly consisted of conduction disorders (70%) such as atrioventricular (AV) block. Out of 126 patients with abnormal Holter findings, 74 (59%) patients had de novo Holter findings including second-degree AV block, atrial fibrillation\/flutter and non-sustained ventricular tachycardia. Patient characteristics were unable to predict the occurrence of de novo Holter findings. In 39 out of 133 (29%) patients with normal ECGs upon yearly cardiac screening, abnormalities were found on Holter monitoring during follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Twenty-four hour Holter monitoring is of added value to routine cardiac screening for all DM1 patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euac104","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T08:38:20Z","timestamp":1658219900000},"page":"156-163","source":"Crossref","is-referenced-by-count":8,"title":["An evaluation of 24 h Holter monitoring in patients with myotonic dystrophy type 1"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1110-6172","authenticated-orcid":false,"given":"Isis B T","family":"Joosten","sequence":"first","affiliation":[{"name":"Department of Neurology, School for Mental Health and Neuroscience (MHeNS), Maastricht University Medical Centre+ , Maastricht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheyenne E W","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Neurology, School for Mental Health and Neuroscience (MHeNS), Maastricht University Medical Centre+ , Maastricht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne G C","family":"Horlings","sequence":"additional","affiliation":[{"name":"Department of Neurology, School for Mental Health and Neuroscience (MHeNS), Maastricht University Medical Centre+ , Maastricht , The Netherlands"},{"name":"Department of Neurology, Medical University Innsbruck , Innsbruck , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4158-0545","authenticated-orcid":false,"given":"Dennis","family":"den Uijl","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre+ , Maastricht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinder","family":"Evertz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Centre , Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baziel G M","family":"van Engelen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre , Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina G","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Neurology, School for Mental Health and Neuroscience (MHeNS), Maastricht University Medical Centre+ , Maastricht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8818-5964","authenticated-orcid":false,"given":"Kevin","family":"Vernooy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre+ , Maastricht , The Netherlands"},{"name":"Department of Cardiology, Radboud University Medical Centre , Nijmegen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,19]]},"reference":[{"key":"2023020817160538700_euac104-B1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ijcard.2011.08.037","article-title":"Cardiac manifestations of myotonic dystrophy type 1","volume":"160","author":"Petri","year":"2012","journal-title":"Int J Cardiol"},{"key":"2023020817160538700_euac104-B2","first-page":"385","article-title":"Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3\u2019 end of a transcript encoding a protein kinase family member","volume":"69","author":"Brook","year":"1992","journal-title":"Cell"},{"key":"2023020817160538700_euac104-B3","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.neurol.2016.08.003","article-title":"Unravelling the myotonic dystrophy type 1 clinical spectrum: a systematic registry-based study with implications for disease classification","volume":"172","author":"De Antonio","year":"2016","journal-title":"Revue Neurologique"},{"key":"2023020817160538700_euac104-B4","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1093\/brain\/121.8.1557","article-title":"Age and causes of death in adult-onset myotonic dystrophy","volume":"121","author":"de Die-Smulders","year":"1998","journal-title":"Brain"},{"key":"2023020817160538700_euac104-B5","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1212\/CPJ.0000000000000531","article-title":"Consensus-based care recommendations for adults with myotonic dystrophy type 1","volume":"8","author":"Ashizawa","year":"2018","journal-title":"Neurol Clin Pract"},{"key":"2023020817160538700_euac104-B6","doi-asserted-by":"crossref","first-page":"e014006","DOI":"10.1161\/JAHA.119.014006","article-title":"Clinical care recommendations for cardiologists treating adults with myotonic dystrophy","volume":"9","author":"McNally","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"2023020817160538700_euac104-B7","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00415-002-0692-6","article-title":"Cardiac involvement and CTG expansion in myotonic dystrophy","volume":"249","author":"Merlevede","year":"2002","journal-title":"J Neurol"},{"key":"2023020817160538700_euac104-B8","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/europace\/euaa256","article-title":"Electrocardiographic predictors of infrahissian conduction disturbances in myotonic dystrophy type 1","volume":"23","author":"Joosten","year":"2021","journal-title":"Europace"},{"key":"2023020817160538700_euac104-B9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/europace\/euab232","article-title":"2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy","volume":"24","author":"Glikson","year":"2022","journal-title":"Europace"},{"key":"2023020817160538700_euac104-B10","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.jacc.2018.10.043","article-title":"2018 ACC\/AHA\/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines, and the Heart Rhythm Society","volume":"74","author":"Kusumoto","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2023020817160538700_euac104-B11","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1212\/WNL.56.3.336","article-title":"Assessment of a disease-specific muscular impairment rating scale in myotonic dystrophy","volume":"56","author":"Mathieu","year":"2001","journal-title":"Neurology"},{"key":"2023020817160538700_euac104-B12","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1001\/jamaneurol.2017.4778","article-title":"Development and validation of a new scoring system to predict survival in patients with myotonic dystrophy type 1","volume":"75","author":"Wahbi","year":"2018","journal-title":"JAMA Neurol"},{"key":"2023020817160538700_euac104-B13","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.tcm.2019.06.001","article-title":"Cardiovascular manifestations of myotonic dystrophy","volume":"30","author":"Wahbi","year":"2020","journal-title":"Trends Cardiovasc Med"},{"key":"2023020817160538700_euac104-B14","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1056\/NEJMoa062800","article-title":"Electrocardiographic abnormalities and sudden death in myotonic dystrophy type 1","volume":"358","author":"Groh","year":"2008","journal-title":"N Engl J Med"},{"key":"2023020817160538700_euac104-B15","doi-asserted-by":"crossref","first-page":"e12587","DOI":"10.1111\/anec.12587","article-title":"Twenty-four-hour ambulatory ECG monitoring relevancy in myotonic dystrophy type 1 follow-up: prognostic value and heart rate variability evolution","volume":"24","author":"Gamet","year":"2019","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"2023020817160538700_euac104-B16","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/europace\/euq423","article-title":"Long-term follow-up of patients with myotonic dystrophy: an electrocardiogram every year is not necessary","volume":"13","author":"Brembilla-Perrot","year":"2011","journal-title":"Europace"},{"key":"2023020817160538700_euac104-B17","first-page":"745","article-title":"Ambulatory electrocardiographic monitoring in type 1 myotonic dystrophy","volume":"26","author":"S\u00e1","year":"2007","journal-title":"Rev Port Cardiol"},{"key":"2023020817160538700_euac104-B18","doi-asserted-by":"crossref","first-page":"e0148264","DOI":"10.1371\/journal.pone.0148264","article-title":"Gender as a modifying factor influencing myotonic dystrophy type 1 phenotype severity and mortality: a nationwide multiple databases cross-sectional observational study","volume":"11","author":"Dogan","year":"2016","journal-title":"PLoS One"},{"key":"2023020817160538700_euac104-B19","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ijcard.2011.05.070","article-title":"Age, conduction defects and restrictive lung disease independently predict cardiac events and death in myotonic dystrophy","volume":"162","author":"Kaminsky","year":"2013","journal-title":"Int J Cardiol"},{"key":"2023020817160538700_euac104-B20","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.nmd.2007.01.014","article-title":"Relationship between cardiac arrhythmias and sleep apnoea in permanently paced patients with type I myotonic dystrophy","volume":"17","author":"Lazarus","year":"2007","journal-title":"Neuromuscul Disord"}],"container-title":["EP Europace"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/25\/1\/156\/49126340\/euac104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/25\/1\/156\/49126340\/euac104.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T17:58:13Z","timestamp":1675879093000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/25\/1\/156\/6646066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,19]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,7,19]]},"published-print":{"date-parts":[[2023,2,8]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euac104","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2022,7,19]]}}}