{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T21:52:06Z","timestamp":1762033926587,"version":"3.37.3"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/01268"],"award-info":[{"award-number":["PI18\/01268"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005859","name":"Heart Rhythm Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005859","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009664","name":"Spanish Society of Cardiology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HL122352","R01-HL118304","R21-HL153694"],"award-info":[{"award-number":["R01-HL122352","R01-HL118304","R21-HL153694"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To determine the spectral dynamics of early spontaneous polymorphic ventricular tachycardia and ventricular fibrillation (PVT\/VF) in humans.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Fifty-eight self-terminated and 173 shock-terminated episodes of spontaneously initiated PVT\/VF recorded by Medtronic implanted cardiac defibrillators (ICDs) in 87 patients with various cardiac pathologies were analyzed by short fast Fourier transform of shifting segments to determine the dynamics of dominant frequency (DF) and regularity index (RI). The progression in the intensity of DF and RI accumulations further quantified the time course of spectral characteristics of the episodes. Episodes of self-terminated PVT\/VF lasted 8.6\u2005s [95% confidence interval (CI): 8.1\u20139.1] and shock-terminated lasted 13.9\u2005s (13.6\u201314.3) (P &amp;lt; 0.001). Recordings from patients with primarily electrical pathologies displayed higher DF and RI values than those from patients with primarily structural pathologies (P &amp;lt; 0.05) independently of ventricular function or antiarrhythmic drug therapy. Regardless of the underlying pathology, the average DF and RI intensities were lower in self-terminated than shock-terminated episodes [DF: 3.67 (4.04\u20134.58) vs. 4.32 (3.46\u20133.93) Hz, P &amp;lt; 0.001; RI: 0.53 (0.48\u20130.56) vs. 0.63 (0.60\u20130.65), P &amp;lt; 0.001]. In a multivariate analysis controlled by the type of pathology and clinical variables, regularity remained an independent predictor of self-termination [hazard ratio: 0.954 (0.928\u20130.980)]. Receiver operating characteristic (ROC) curve analysis of DF and RI intensities demonstrated increased predictability for self-termination in time with 95% CI above the 0.5 cut-off limit at about t = 8.6\u2005s and t = 6.95\u2005s, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Consistent with the notion that fast organized sources maintain PVT\/VF in humans, reduction of frequency and regularity correlates with early self-termination. Our findings might help generate ICD methods aiming to reduce inappropriate shock deliveries.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euac107","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T08:58:12Z","timestamp":1658221092000},"page":"1788-1799","source":"Crossref","is-referenced-by-count":1,"title":["Distinct spectral dynamics of implanted cardiac defibrillator signals in spontaneous termination of polymorphic ventricular tachycardia and fibrillation in patients with electrical and structural diseases"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8689-4011","authenticated-orcid":false,"given":"David","family":"Calvo","sequence":"first","affiliation":[{"name":"Arrhythmia Unit, Hospital Universitario Central de Asturias , Avd. Roma, s\/n; 33011, Oviedo , Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias , Oviedo , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Salinas","sequence":"additional","affiliation":[{"name":"Center for Arrhythmia Research, University of Michigan , Ann Arbor , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Mart\u00ednez-Camblor","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science, Geisel Medical School , Hanover, NH , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Garc\u00eda-Iglesias","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Hospital Universitario Central de Asturias , Avd. Roma, s\/n; 33011, Oviedo , Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias , Oviedo , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Alzueta","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Hospital Virgen de la Victoria , M\u00e1laga , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anibal","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Hospital Universitario de Canarias , Canarias , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Romero","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Hospital Universitario Ntra Se\u00f1ora de la Candelaria , Canarias , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Vi\u00f1olas","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Hospital Sant Pau , Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Fern\u00e1ndez-Lozano","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Hospital Puerta de Hierro-Majadahonda , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignasi","family":"Anguera","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Hospital Bellvitge , Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juli\u00e1n","family":"Villacast\u00edn","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Hospital Cl\u00ednico San Carlos , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Bodegas","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Hospital de Cruces , Bilbao , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6674-7543","authenticated-orcid":false,"given":"Adolfo","family":"Fontenla","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Hospital 12 de Octubre , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Jalife","sequence":"additional","affiliation":[{"name":"Center for Arrhythmia Research, University of Michigan , Ann Arbor , USA"},{"name":"Cardiac Arrhythmia Laboratory, Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC) , Madrid , Spain"},{"name":"CIBER de Enfermedades Cardiovasculares (CIBERCV) , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Berenfeld","sequence":"additional","affiliation":[{"name":"Center for Arrhythmia Research, University of Michigan , Ann Arbor , 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