{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:38:12Z","timestamp":1790181492834,"version":"4.1.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Accessory pathway (AP) ablation is a standard procedure for the treatment of Wolff-Parkinson-White syndrome (WPW). Twelve-lead electrocardiogram (ECG)-based delta wave analysis is essential for predicting ablation sites. Previous algorithms have shown to be complex, time-consuming, and unprecise. We aimed to retrospectively develop and prospectively validate a new, simple ECG-based algorithm considering the patients\u2019 heart axis allowing for exact localization of APs in patients undergoing ablation for WPW.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Our multicentre study included 211 patients undergoing ablation of a single manifest AP due to WPW between 2013 and 2021. The algorithm was developed retrospectively and validated prospectively by comparing its efficacy to two established ones (Pambrun and Arruda). All patients (32 \u00b1 19 years old, 47% female) underwent successful pathway ablation. Prediction of AP-localization was correct in 197 patients (93%) (sensitivity 92%, specificity 99%, PPV 96%, and NPV 99%). Our algorithm was particularly useful in correctly localizing antero-septal\/-lateral (sensitivity and specificity 100%) and posteroseptal (sensitivity 98%, specificity 92%) AP in proximity to the tricuspid valve. The accuracy of EASY-WPW was superior compared to the Pambrun (93% vs. 84%, P = 0.003*) and the Arruda algorithm (94% vs. 75%, P &amp;lt; 0.001*). A subgroup analysis of children (n = 58, 12 \u00b1 4 years old, 55% female) revealed superiority to the Arruda algorithm (P &amp;lt; 0.001*). The reproducibility of our algorithm was excellent (\u03f0&amp;gt;0.8; P &amp;lt; 0.001*).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The novel EASY-WPW algorithm provides reliable and accurate pre-interventional ablation site determination in WPW patients. Only two steps are necessary to locate left-sided AP, and three steps to determine right-sided AP.<\/jats:p><\/jats:sec>","DOI":"10.1093\/europace\/euac216","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T13:18:10Z","timestamp":1670851090000},"page":"600-609","source":"Crossref","is-referenced-by-count":30,"title":["EASY-WPW: a novel ECG-algorithm for easy and reliable localization of manifest accessory pathways in children and adults"],"prefix":"10.1093","volume":"25","author":[{"given":"Mustapha","family":"El Hamriti","sequence":"first","affiliation":[{"name":"Clinic for Electrophysiology, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum , Georgstr. 11, 32545 Bad Oeynhausen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Braun","sequence":"additional","affiliation":[{"name":"Clinic for Electrophysiology, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum , Georgstr. 11, 32545 Bad 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3566-4822","authenticated-orcid":false,"given":"Khuraman","family":"Isgandarova","sequence":"additional","affiliation":[{"name":"Clinic for Electrophysiology, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum , Georgstr. 11, 32545 Bad Oeynhausen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6303-2040","authenticated-orcid":false,"given":"Vanessa","family":"Sciacca","sequence":"additional","affiliation":[{"name":"Clinic for Electrophysiology, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum , Georgstr. 11, 32545 Bad Oeynhausen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6665-7326","authenticated-orcid":false,"given":"Thomas","family":"Fink","sequence":"additional","affiliation":[{"name":"Clinic for Electrophysiology, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum , Georgstr. 11, 32545 Bad Oeynhausen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0215-6688","authenticated-orcid":false,"given":"Leonard","family":"Bergau","sequence":"additional","affiliation":[{"name":"Clinic for Electrophysiology, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum , Georgstr. 11, 32545 Bad Oeynhausen , Germany"},{"name":"Clinic for Cardiology, University Goettingen , Robert-Koch-Str. 40, 37075 Goettingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0490-5862","authenticated-orcid":false,"given":"Christian","family":"Sohns","sequence":"additional","affiliation":[{"name":"Clinic for Electrophysiology, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum , Georgstr. 11, 32545 Bad Oeynhausen , 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