{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:59:06Z","timestamp":1791863946984,"version":"4.3.4"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006190","name":"Research and Development","doi-asserted-by":"crossref","award":["2018YFC1312501"],"award-info":[{"award-number":["2018YFC1312501"]}],"id":[{"id":"10.13039\/100006190","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Commission of Science","award":["D171100006817001"],"award-info":[{"award-number":["D171100006817001"]}]},{"DOI":"10.13039\/100001236","name":"Medical Foundation","doi-asserted-by":"crossref","award":["ZNSA-202001"],"award-info":[{"award-number":["ZNSA-202001"]}],"id":[{"id":"10.13039\/100001236","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study sought to assess the effect of ethanol infusion into the vein of Marshall (EIVOM) on the acute success of left pulmonary vein (LPV) isolation in persistent atrial fibrillation (PeAF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A total of 313 patients with drug-resistant PeAF were enrolled (135 in Group 1 and 178 in Group 2). In Group 1, EIVOM was firstly performed, followed by radiofrequency ablation (RFA) including bilateral pulmonary vein isolation (PVI) and linear ablation at roofline, cavotricuspid isthmus, and mitral isthmus (MI). In Group 2, PVI and linear ablations were completed with RFA. First-pass isolation of the LPV was achieved in 119 (88.1%) and 132 (74.2%) patients in Groups 1 and 2, respectively (P = 0.002). The rate of acute pulmonary vein reconnection (PVR) was significantly lower in Group 1 (9.6% vs. 22.5%, P = 0.003). About half of acute PVR occurred in the carina with or without EIVOM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>EIVOM is effective in achieving a higher first-pass isolation and a lower acute PVR of LPV in PeAF.<\/jats:p><\/jats:sec>","DOI":"10.1093\/europace\/euac219","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T13:27:24Z","timestamp":1670851644000},"page":"441-449","source":"Crossref","is-referenced-by-count":32,"title":["The adjunctive effect for left pulmonary vein isolation of vein of Marshall ethanol infusion in persistent atrial fibrillation"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7261-316X","authenticated-orcid":false,"given":"Lihong","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University , No 2, Anzhen Rd, Chaoyang District, 100029 Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8304-7909","authenticated-orcid":false,"given":"Mingyang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University , No 2, Anzhen Rd, Chaoyang District, 100029 Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0592-6462","authenticated-orcid":false,"given":"Yiwei","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University , No 2, Anzhen Rd, Chaoyang District, 100029 Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4461-2995","authenticated-orcid":false,"given":"Qi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University , No 2, Anzhen Rd, Chaoyang District, 100029 Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3139-663X","authenticated-orcid":false,"given":"Songnan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University , No 2, Anzhen Rd, Chaoyang District, 100029 Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University , No 2, Anzhen Rd, Chaoyang District, 100029 Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University , No 2, Anzhen Rd, Chaoyang District, 100029 Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University , No 2, Anzhen Rd, Chaoyang District, 100029 Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8874-6955","authenticated-orcid":false,"given":"Xiaoxia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University , No 2, Anzhen Rd, Chaoyang District, 100029 Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University , No 2, Anzhen Rd, Chaoyang District, 100029 Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University , No 2, Anzhen Rd, Chaoyang District, 100029 Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3663-6097","authenticated-orcid":false,"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University , No 2, Anzhen Rd, Chaoyang District, 100029 Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University , No 2, Anzhen Rd, Chaoyang District, 100029 Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5421-4421","authenticated-orcid":false,"given":"Caihua","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University , No 2, Anzhen Rd, Chaoyang District, 100029 Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2812-1827","authenticated-orcid":false,"given":"Ribo","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University , No 2, Anzhen Rd, Chaoyang District, 100029 Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4604-5346","authenticated-orcid":false,"given":"Deyong","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University , No 2, Anzhen Rd, Chaoyang District, 100029 Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7463-8707","authenticated-orcid":false,"given":"Xin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University , No 2, Anzhen Rd, Chaoyang District, 100029 Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7299-7805","authenticated-orcid":false,"given":"Jianzeng","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University , No 2, Anzhen Rd, Chaoyang District, 100029 Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5387-5957","authenticated-orcid":false,"given":"Chang-sheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University , No 2, Anzhen Rd, Chaoyang District, 100029 Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"e275","DOI":"10.1016\/j.hrthm.2017.05.012","article-title":"2017 HRS\/EHRA\/ECAS\/APHRS\/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation","volume":"14","author":"Calkins","year":"2017","journal-title":"Heart Rhythm"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jacep.2016.02.003","article-title":"Relationship between pulmonary vein reconnection and atrial fibrillation recurrence: a systematic review and meta-analysis","volume":"2","author":"Nery","year":"2016","journal-title":"JACC Clin Electrophysiol"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1161\/01.CIR.0000151289.73085.36","article-title":"Recovered pulmonary vein conduction as a dominant factor for recurrent atrial tachyarrhythmias after complete circular isolation of the pulmonary veins: lessons from double Lasso technique","volume":"111","author":"Ouyang","year":"2005","journal-title":"Circulation"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s10840-016-0172-z","article-title":"Pulmonary vein reconnection following catheter ablation of atrial fibrillation using the second-generation cryoballoon versus open-irrigated radiofrequency: results of a multicenter analysis","volume":"47","author":"Aryana","year":"2016","journal-title":"J Intervent Cardiac Electrophysiol"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1046\/j.1540-8167.2004.04052.x","article-title":"Efficacy of repeat pulmonary vein isolation procedures in patients with recurrent atrial fibrillation","volume":"15","author":"Callans","year":"2004","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1093\/europace\/euab279","article-title":"Radiofrequency ablation to achieve durable pulmonary vein isolation","volume":"24","author":"Mulder","year":"2022","journal-title":"Europace"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1001\/jama.2020.16195","article-title":"Effect of catheter ablation with vein of Marshall ethanol infusion vs catheter ablation alone on persistent atrial fibrillation: the VENUS randomized clinical trial","volume":"324","author":"Valderr\u00e1bano","year":"2020","journal-title":"JAMA"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/jce.13797","article-title":"MARSHALL bundles elimination, pulmonary veins isolation and lines completion for anatomical ablation of persistent atrial fibrillation: MARSHALL-PLAN case series","volume":"30","author":"Pambrun","year":"2019","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1111\/jce.15108","article-title":"Effectiveness of ethanol infusion into the vein of Marshall combined with a fixed anatomical ablation strategy (the \u201cupgraded 2C3L\u201d approach) for catheter ablation of persistent atrial fibrillation","volume":"32","author":"Lai","year":"2021","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.hrthm.2009.07.036","article-title":"Ethanol infusion in the vein of Marshall: adjunctive effects during ablation of atrial fibrillation","volume":"6","author":"Valderr\u00e1bano","year":"2009","journal-title":"Heart Rhythm"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1111\/jce.15028","article-title":"Predictors of clinical success after paroxysmal atrial fibrillation catheter ablation","volume":"32","author":"Osorio","year":"2021","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ipej.2019.05.001","article-title":"Ablation-index guided versus conventional contact-force guided ablation in pulmonary vein isolation \u2013 systematic review and meta-analysis","volume":"19","author":"Pranata","year":"2019","journal-title":"Indian Pacing Electrophysiol J"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1093\/europace\/euaa224","article-title":"Efficacy and safety of ablation index-guided catheter ablation for atrial fibrillation: an updated meta-analysis","volume":"22","author":"Ioannou","year":"2020","journal-title":"Europace"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1111\/jce.14673","article-title":"Clinical outcome of pulmonary vein isolation alone ablation strategy using VISITAG SURPOINT in nonparoxysmal atrial fibrillation","volume":"31","author":"Yamaguchi","year":"2020","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1540-8167.2011.02268.x","article-title":"Role of the vein of Marshall in atrial fibrillation recurrences after catheter ablation: therapeutic effect of ethanol infusion","volume":"23","author":"Dave","year":"2012","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"688","DOI":"10.33963\/KP.15318","article-title":"Topography of the oblique vein of the left atrium (vein of Marshall)","volume":"78","author":"\u017bab\u00f3wka","year":"2020","journal-title":"Kardiol Pol"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.jacep.2017.02.022","article-title":"The human left atrial venous circulation as a vascular route for atrial pharmacological therapies: effects of ethanol infusion","volume":"3","author":"Valderr\u00e1bano","year":"2017","journal-title":"JACC Clin Electrophysiol"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1111\/jce.15573","article-title":"Distribution of atrial low voltage induced by vein of Marshall ethanol infusion","volume":"33","author":"Kamakura","year":"2022","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"H312","DOI":"10.1152\/ajpheart.00369.2005","article-title":"Electrical connections between left superior pulmonary vein, left atrium, and ligament of Marshall: implications for mechanisms of atrial fibrillation","volume":"290","author":"Tan","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"e007544","DOI":"10.1161\/CIRCEP.119.007544","article-title":"Epicardial connections involving pulmonary veins: the prevalence, predictors, and implications for ablation outcome","volume":"13","author":"Barrio-Lopez","year":"2020","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jacep.2021.11.019","article-title":"Vein of Marshall ethanol infusion as first step for mitral isthmus linear ablation","volume":"8","author":"Gillis","year":"2022","journal-title":"JACC Clin Electrophysiol"},{"key":"2023021623590291200_","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1093\/europace\/euaa137","article-title":"Acute and mid-term outcome of ethanol infusion of vein of Marshall for the treatment of perimitral flutter","volume":"22","author":"Takigawa","year":"2020","journal-title":"Europace"}],"container-title":["EP Europace"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/25\/2\/441\/49231085\/euac219.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/25\/2\/441\/49231085\/euac219.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,12]],"date-time":"2023-03-12T03:57:00Z","timestamp":1678593420000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/25\/2\/441\/6887911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,12]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,12,12]]},"published-print":{"date-parts":[[2023,2,16]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euac219","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,2,1]]},"published":{"date-parts":[[2022,12,12]]}}}