{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:16:54Z","timestamp":1789766214497,"version":"4.0.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["1R01HL142893-01"],"award-info":[{"award-number":["1R01HL142893-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Post-infarct myocardium contains viable corridors traversing scar or lipomatous metaplasia (LM). Ventricular tachycardia (VT) circuitry has been separately reported to associate with corridors that traverse LM and with repolarization heterogeneity. We examined the association of corridor activation recovery interval (ARI) and ARI dispersion with surrounding tissue type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The cohort included 33 post-infarct patients from the prospective Intra-Myocardial Fat Deposition and Ventricular Tachycardia in Cardiomyopathy (INFINITY) study. We co-registered scar and corridors from late gadolinium enhanced magnetic resonance, and LM from computed tomography with intracardiac electrogram locations. Activation recovery interval was calculated during sinus or ventricular pacing, as the time interval from the minimum derivative within the QRS to the maximum derivative within the T-wave on unipolar electrograms. Regional ARI dispersion was defined as the standard deviation (SD) of ARI per AHA segment (ARISD). Lipomatous metaplasia exhibited higher ARI than scar [325 (interquartile range 270\u2013392) vs. 313 (255\u2013374), P &amp;lt; 0.001]. Corridors critical to VT re-entry were more likely to traverse through or near LM and displayed prolonged ARI compared with non-critical corridors [355 (319\u2013397) vs. 302 (279\u2013333) ms, P &amp;lt; 0.001]. ARISD was more closely associated with LM than with scar (likelihood ratio \u03c72 50 vs. 12, and 4.2-unit vs. 0.9-unit increase in 0.01*Log(ARISD) per 1 cm2 increase per AHA segment). Additionally, LM and scar exhibited interaction (P &amp;lt; 0.001) in their association with ARISD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lipomatous metaplasia is closely associated with prolonged local action potential duration of corridors and ARI dispersion, which may facilitate the propensity of VT circuit re-entry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euac222","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T18:17:36Z","timestamp":1668622656000},"page":"496-505","source":"Crossref","is-referenced-by-count":20,"title":["Lipomatous metaplasia prolongs repolarization and increases repolarization dispersion within post-infarct ventricular tachycardia circuit cites"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-8371","authenticated-orcid":false,"given":"Lingyu","family":"Xu","sequence":"first","affiliation":[{"name":"Cardiovascular Medicine Division, University of Pennsylvania School of Medicine , 3400 Spruce Street, Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohail","family":"Zahid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, NYU Langone Medical Center , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirmilad","family":"Khoshknab","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Division, University of Pennsylvania School of Medicine , 3400 Spruce Street, Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6698-0679","authenticated-orcid":false,"given":"Juwann","family":"Moss","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Division, University of Pennsylvania School of Medicine , 3400 Spruce Street, Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-6750","authenticated-orcid":false,"given":"Ronald D","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Johns Hopkins University , Baltimore, MD , USA"},{"name":"Department of Cardiology, Johns Hopkins University , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7985-3019","authenticated-orcid":false,"given":"Jonathan","family":"Chrispin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Johns Hopkins University , Baltimore, MD , USA"},{"name":"Department of Cardiology, Johns Hopkins University , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Callans","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Division, University of Pennsylvania School of Medicine , 3400 Spruce Street, Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7962-9423","authenticated-orcid":false,"given":"Francis E","family":"Marchlinski","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Division, University of Pennsylvania School of Medicine , 3400 Spruce Street, Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9422-6742","authenticated-orcid":false,"given":"Stefan L","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Johns Hopkins University , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7582-1848","authenticated-orcid":false,"given":"Yuchi","family":"Han","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Division, University of Pennsylvania School of Medicine , 3400 Spruce Street, Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0693-4982","authenticated-orcid":false,"given":"Benoit","family":"Desjardins","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Pennsylvania School of Medicine , Philadelphia, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8661-063X","authenticated-orcid":false,"given":"Natalia","family":"Trayanova","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Johns Hopkins University , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8369-0259","authenticated-orcid":false,"given":"Saman","family":"Nazarian","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Division, University of Pennsylvania School of Medicine , 3400 Spruce Street, Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"2023021623580459600_","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1053\/euhj.1999.1732","article-title":"Dispersion of ventricular repolarization is determined by the presence of myocardial viability in patients with old myocardial infarction\u2014a dobutamine stress echocardiography study","volume":"21","author":"Ikonomidis","year":"2000","journal-title":"Eur Heart J"},{"key":"2023021623580459600_","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/europace\/euy260","article-title":"Prolonged action potential duration and dynamic transmural action potential duration heterogeneity underlie vulnerability to ventricular tachycardia in patients undergoing ventricular tachycardia ablation","volume":"21","author":"Srinivasan","year":"2019","journal-title":"Europace"},{"key":"2023021623580459600_","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.hrthm.2018.11.013","article-title":"Left ventricular activation-recovery interval variability predicts spontaneous ventricular tachyarrhythmia in patients with heart failure","volume":"16","author":"Porter","year":"2019","journal-title":"Heart Rhythm"},{"key":"2023021623580459600_","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4330\/wjc.v8.i1.57","article-title":"Ventricular repolarization measures for arrhythmic risk stratification","volume":"8","author":"Monitillo","year":"2016","journal-title":"World J Cardiol"},{"key":"2023021623580459600_","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1161\/01.CIR.0000141734.43393.BE","article-title":"Determination of human ventricular repolarization by noncontact mapping: validation with monophasic action potential recordings","volume":"110","author":"Yue","year":"2004","journal-title":"Circulation"},{"key":"2023021623580459600_","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1161\/01.CIR.72.6.1372","article-title":"Correlation between refractory periods and activation-recovery intervals from electrograms\u2014effects of rate and adrenergic interventions","volume":"72","author":"Millar","year":"1985","journal-title":"Circulation"},{"key":"2023021623580459600_","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.hrthm.2006.05.027","article-title":"Monophasic action potentials and activation recovery intervals as measures of ventricular action potential duration: experimental evidence to resolve some controversies","volume":"3","author":"Coronel","year":"2006","journal-title":"Heart Rhythm"},{"key":"2023021623580459600_","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1161\/01.CIR.77.3.589","article-title":"Reentry as a cause of ventricular-tachycardia in patients with chronic ischemic heart-disease\u2014electrophysiologic and anatomic correlation","volume":"77","author":"Debakker","year":"1988","journal-title":"Circulation"},{"key":"2023021623580459600_","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1161\/CIRCULATIONAHA.113.002238","article-title":"Intramyocardial adiposity after myocardial infarction: new implications of a substrate for ventricular tachycardia","volume":"128","author":"Pouliopoulos","year":"2013","journal-title":"Circulation"},{"key":"2023021623580459600_","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.hrthm.2015.03.041","article-title":"New insight into scar-related ventricular tachycardia circuits in ischemic cardiomyopathy: fat deposition after myocardial infarction on computed tomography-a pilot study","volume":"12","author":"Sasaki","year":"2015","journal-title":"Heart Rhythm"},{"key":"2023021623580459600_","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.jacep.2022.07.005","article-title":"Lipomatous metaplasia enables ventricular tachycardia by reducing current loss within the protected corridor","volume":"8","author":"Xu","year":"2022","journal-title":"JACC Clin Electrophysiol"},{"key":"2023021623580459600_","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12410-010-9012-1","article-title":"Myocardial fat imaging","volume":"3","author":"Kellman","year":"2010","journal-title":"Curr Cardiovasc Imaging Rep"},{"key":"2023021623580459600_","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.hrthm.2015.09.023","article-title":"Substrate mapping for unstable ventricular tachycardia","volume":"13","author":"Santangeli","year":"2016","journal-title":"Heart Rhythm"},{"key":"2023021623580459600_","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.molmed.2015.12.006","article-title":"The living scar\u2014cardiac fibroblasts and the injured heart","volume":"22","author":"Rog-Zielinska","year":"2016","journal-title":"Trends Mol Med"},{"key":"2023021623580459600_","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.hrthm.2015.04.013","article-title":"An activation-repolarization time metric to predict localized regions of high susceptibility to reentry","volume":"12","author":"Child","year":"2015","journal-title":"Heart Rhythm"},{"key":"2023021623580459600_","volume-title":"Josephson's clinical cardiac electrophysiology: techniques and interpretation","author":"Callans","year":"2020","edition":"6th ed."},{"key":"2023021623580459600_","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jacep.2022.03.002","article-title":"Repolarization heterogeneity in human post-infarct ventricular tachycardia","volume":"8","author":"Callans","year":"2022","journal-title":"JACC Clin Electrophysiol"},{"key":"2023021623580459600_","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/107424849600100401","article-title":"Amiodarone and homogeneity of ventricular repolarization and refractoriness","volume":"1","author":"Singh","year":"1996","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"2023021623580459600_","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1001\/jama.298.11.1312","article-title":"Prescribing amiodarone: an evidence-based review of clinical indications","volume":"298","author":"Vassallo","year":"2007","journal-title":"JAMA"},{"key":"2023021623580459600_","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1161\/01.RES.49.2.511","article-title":"Effect of autonomic blockade on ventricular refractoriness and atrioventricular nodal conduction in humans. Evidence supporting a direct cholinergic action on ventricular muscle refractoriness","volume":"49","author":"Prystowsky","year":"1981","journal-title":"Circ Res"}],"container-title":["EP Europace"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/25\/2\/496\/49231020\/euac222.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/25\/2\/496\/49231020\/euac222.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,12]],"date-time":"2023-03-12T10:13:44Z","timestamp":1678616024000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/25\/2\/496\/6909001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,15]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,12,15]]},"published-print":{"date-parts":[[2023,2,16]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euac222","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,2,1]]},"published":{"date-parts":[[2022,12,15]]}}}