{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:12:33Z","timestamp":1788214353169,"version":"build-2803163510"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Emerging data show that complete revascularization (CR) reduces cardiovascular death and recurrent myocardial infarction in ST-segment elevation myocardial infarction (STEMI). However, the influence of revascularization status on development of arrhythmia in the long-term post-STEMI phase is poorly described. We hypothesized that incomplete revascularization (ICR) compared with CR in STEMI is associated with an increased long-term risk of new-onset arrhythmia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Patients with STEMI treated with primary percutaneous coronary intervention (PPCI) at Copenhagen University Hospital, Rigshospitalet, Denmark, with CR or ICR were identified via the Eastern Danish Heart registry from 2009 to 2016. Using unique Danish administrative registries, the outcomes were assessed. The primary outcome was new-onset arrhythmia defined as a composite of atrial fibrillation\/flutter (AF), sinoatrial block, advanced second- or third-degree atrioventricular block, ventricular tachycardia\/fibrillation (VT), or cardiac arrest (CA), with presentation &amp;gt;7 days post-PPCI. Secondary outcomes were the components of the primary outcome and all-cause mortality. A total of 5103 patients (median age: 62.0 years; 76% men) were included, of whom 4009 (79%) and 1094 (21%) patients underwent CR and ICR, respectively. Compared with CR, ICR was associated with a higher risk of new-onset arrhythmia [hazard ratio (HR), 1.33; 95% confidence interval (CI), 1.07\u20131.66; P = 0.01], AF (HR, 1.29; 95% CI, 1.00\u20131.66; P = 0.05), a combined outcome of VT and CA (HR, 1.77; 95% CI, 1.10\u20132.84; P = 0.02) and all-cause mortality (HR, 1.27; 95% CI, 1.05\u20131.53; P = 0.01). All HRs adjusted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among patients with STEMI, ICR was associated with an increased long-term risk of new-onset arrhythmia and all-cause mortality compared with CR.<\/jats:p><\/jats:sec>","DOI":"10.1093\/europace\/euac242","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T23:19:40Z","timestamp":1671146380000},"page":"931-939","source":"Crossref","is-referenced-by-count":8,"title":["Long-term risk of new-onset arrhythmia in ST-segment elevation myocardial infarction according to revascularization status"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3916-7567","authenticated-orcid":false,"given":"Anna F","family":"Thomsen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Rigshospitalet University Hospital , Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1876-2623","authenticated-orcid":false,"given":"Christian","family":"J\u00f8ns","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet University Hospital , Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9432-0632","authenticated-orcid":false,"given":"Reza","family":"Jabbari","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet University Hospital , Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3990-4176","authenticated-orcid":false,"given":"Mia R","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet University Hospital , Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2510-1046","authenticated-orcid":false,"given":"Niels Kj\u00e6r","family":"Stampe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet University Hospital , Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7380-4144","authenticated-orcid":false,"given":"Jawad H","family":"Butt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet University Hospital , Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1466-5225","authenticated-orcid":false,"given":"Niels Thue","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gentofte University Hospital , Gentofte Hospitalsvej 1, 2900 Hellerup , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8293-3733","authenticated-orcid":false,"given":"Henning","family":"Kelb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zealand University Hospital , Sygehusvej 10, 4000 Roskilde , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2892-6131","authenticated-orcid":false,"given":"Christian","family":"Torp-Pedersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, North Zealand University Hospital , Dyrehavevej 29, 3400 Hilleroed , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2048-4167","authenticated-orcid":false,"given":"Emil L","family":"Fosb\u00f8l","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet University Hospital , Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0071-3209","authenticated-orcid":false,"given":"Frants","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet University Hospital , Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-1466","authenticated-orcid":false,"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet University Hospital , Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Engstr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet University Hospital , Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Karl","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet University Hospital , Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"2023033021231195000_","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur Heart J"},{"key":"2023033021231195000_","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/eurheartj\/ehv320","article-title":"2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: task force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent 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