{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:09:45Z","timestamp":1788206985861,"version":"build-2803163510"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Left bundle branch area pacing (LBBAP) is a promising method for delivering cardiac resynchronization therapy (CRT), but its relative physiological effectiveness compared with His bundle pacing (HBP) is unknown. We conducted a within-patient comparison of HBP, LBBAP, and biventricular pacing (BVP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Patients referred for CRT were recruited. We assessed electrical response using non-invasive mapping, and acute haemodynamic response using a high-precision haemodynamic protocol. Nineteen patients were recruited: 14 male, mean LVEF of 30%. Twelve had time for BVP measurements. All three modalities reduced total ventricular activation time (TVAT), (\u0394TVATHBP -43 \u00b1 14 ms and \u0394TVATLBBAP \u221235 \u00b1 20 ms vs. \u0394TVATBVP \u221219 \u00b1 30 ms, P = 0.03 and P = 0.1, respectively). HBP produced a significantly greater reduction in TVAT compared with LBBAP in all 19 patients (\u221246 \u00b1 15 ms, \u221236 \u00b1 17 ms, P = 0.03). His bundle pacing and LBBAP reduced left ventricular activation time (LVAT) more than BVP (\u0394LVATHBP \u221243 \u00b1 16 ms, P &amp;lt; 0.01 vs. BVP, \u0394LVATLBBAP \u221245 \u00b1 17 ms, P &amp;lt; 0.01 vs. BVP, \u0394LVATBVP \u221213 \u00b1 36 ms), with no difference between HBP and LBBAP (P = 0.65). Acute systolic blood pressure was increased by all three modalities. In the 12 with BVP, greater improvement was seen with HBP and LBBAP (6.4 \u00b1 3.8 mmHg BVP, 8.1 \u00b1 3.8 mmHg HBP, P = 0.02 vs. BVP and 8.4 \u00b1 8.2 mmHg for LBBAP, P = 0.3 vs. BVP), with no difference between HBP and LBBAP (P = 0.8).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HBP delivered better ventricular resynchronization than LBBAP because right ventricular activation was slower during LBBAP. But LBBAP was not inferior to HBP with respect to LV electrical resynchronization and acute haemodynamic response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euac245","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T17:36:17Z","timestamp":1670002577000},"page":"1060-1067","source":"Crossref","is-referenced-by-count":59,"title":["Comparison of methods for delivering cardiac resynchronization therapy: an acute electrical and haemodynamic within-patient comparison of left bundle branch area, His bundle, and biventricular pacing"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3169-4776","authenticated-orcid":false,"given":"Nadine","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Cardiology, National Heart and Lung Institute, Imperial College London , Hammersmith Hospital Du Cane Road, London W120HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7597-0170","authenticated-orcid":false,"given":"Ahran D","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart and Lung Institute, Imperial College London , Hammersmith Hospital Du Cane Road, London W120HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1958-7027","authenticated-orcid":false,"given":"Alejandra A","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart and Lung Institute, Imperial College London , Hammersmith Hospital Du Cane Road, London W120HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7472-7358","authenticated-orcid":false,"given":"Daniel","family":"Keene","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart and Lung Institute, Imperial College London , Hammersmith Hospital Du Cane Road, London W120HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2454-7644","authenticated-orcid":false,"given":"Ji-Jian","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart and Lung Institute, Imperial College London , Hammersmith Hospital Du Cane Road, London W120HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Little","sequence":"additional","affiliation":[{"name":"Medtronic Limited , Building 9, Croxley Green Business Park, Watford WD18 8WW , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3581-8078","authenticated-orcid":false,"given":"Nicholas S","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart and Lung Institute, Imperial College London , Hammersmith Hospital Du Cane Road, London W120HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3593-2185","authenticated-orcid":false,"given":"Prapa","family":"Kanagaratnam","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart and Lung Institute, Imperial College London , Hammersmith Hospital Du Cane Road, London W120HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1385-5484","authenticated-orcid":false,"given":"Norman","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart and Lung Institute, Imperial College London , Hammersmith Hospital Du Cane Road, London W120HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8681-4368","authenticated-orcid":false,"given":"Fu Siong","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart and Lung Institute, Imperial College London , Hammersmith Hospital Du Cane Road, London W120HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5712-849X","authenticated-orcid":false,"given":"Nick W F","family":"Linton","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart and Lung Institute, Imperial College London , Hammersmith Hospital Du Cane Road, London W120HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1595-8292","authenticated-orcid":false,"given":"David C","family":"Lefroy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart and Lung Institute, Imperial College London , Hammersmith Hospital Du Cane Road, London W120HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3410-0814","authenticated-orcid":false,"given":"Darrel P","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart and Lung Institute, Imperial College London , Hammersmith Hospital Du Cane Road, London W120HS , UK"},{"name":"Department of Cardiology, St Richards Hospital, University Hospitals Sussex NHS Foundation Trust. , Spitalfield Ln, Chichester PO19 6SE , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4888-0070","authenticated-orcid":false,"given":"Lim","family":"Phang Boon","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart and Lung Institute, Imperial College London , Hammersmith Hospital Du Cane Road, London W120HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6706-6536","authenticated-orcid":false,"given":"Mark A","family":"Tanner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Richards Hospital, University Hospitals Sussex NHS Foundation Trust. , Spitalfield Ln, Chichester PO19 6SE , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Muthumala","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Bartholomew\u2019s Hospital and North Middlesex University Hospital , W Smithfield, London EC1A 7BE , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1179-0867","authenticated-orcid":false,"given":"Matthew J","family":"Shun-Shin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart and Lung Institute, Imperial College London , Hammersmith Hospital Du Cane Road, London W120HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3157-0335","authenticated-orcid":false,"given":"Graham D","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart and Lung Institute, Imperial College London , Hammersmith Hospital Du Cane Road, London W120HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2775-5126","authenticated-orcid":false,"given":"Zachary I","family":"Whinnett","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart and Lung Institute, Imperial College London , Hammersmith Hospital Du Cane Road, London W120HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"2023033014150842800_","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1111\/jce.14064","article-title":"His bundle pacing, learning curve, procedure characteristics, safety, and feasibility: insights from a large international observational study","volume":"30","author":"Keene","year":"2019","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2023033014150842800_","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.hrthm.2017.12.022","article-title":"Permanent his-bundle pacing: long-term lead performance and clinical outcomes","volume":"15","author":"Vijayaraman","year":"2018","journal-title":"Heart Rhythm"},{"key":"2023033014150842800_","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.hrthm.2019.05.009","article-title":"On-treatment comparison between corrective his bundle pacing and biventricular pacing for cardiac resynchronization: a secondary analysis of the his-SYNC pilot trial","volume":"16","author":"Upadhyay","year":"2019","journal-title":"Heart Rhythm"},{"key":"2023033014150842800_","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1161\/CIRCULATIONAHA.118.038648","article-title":"Intracardiac delineation of septal conduction in left bundle-branch block patterns","volume":"139","author":"Upadhyay","year":"2019","journal-title":"Circulation"},{"key":"2023033014150842800_","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.hrthm.2019.06.016","article-title":"A beginner\u2019s guide to permanent left bundle branch pacing","volume":"16","author":"Huang","year":"2019","journal-title":"Heart Rhythm"},{"key":"2023033014150842800_","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jacep.2020.08.015","article-title":"Left bundle branch area pacing for cardiac resynchronization therapy: results from the international LBBAP collaborative study group","volume":"7","author":"Vijayaraman","year":"2021","journal-title":"JACC Clin Electrophysiol"},{"key":"2023033014150842800_","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1111\/pace.12904","article-title":"How to perform permanent his bundle pacing: tips and tricks","volume":"39","author":"Vijayaraman","year":"2016","journal-title":"Pacing Clin 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The effect of cardiac resynchronization on morbidity and mortality in heart failure","volume":"352","author":"Cleland","year":"2005","journal-title":"N Engl J Med"},{"key":"2023033014150842800_","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.hrthm.2014.12.031","article-title":"Electrical dyssynchrony induced by biventricular pacing: implications for patient selection and therapy improvement","volume":"12","author":"Ploux","year":"2015","journal-title":"Heart Rhythm"},{"key":"2023033014150842800_","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.jacc.2011.06.007","article-title":"Implantation-related complications of implantable cardioverter-defibrillators and cardiac resynchronization therapy devices: a systematic review of randomized clinical trials","volume":"58","author":"van Rees","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2023033014150842800_","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1016\/j.jacc.2018.09.073","article-title":"His resynchronization versus biventricular pacing in patients with heart failure and left bundle branch block","volume":"72","author":"Arnold","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2023033014150842800_","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1093\/europace\/euu374","article-title":"Evidence that conflict regarding size of haemodynamic response to interventricular delay optimization of cardiac resynchronization therapy may arise from differences in how atrioventricular delay is kept constant","volume":"17","author":"Sohaib","year":"2015","journal-title":"Europace"},{"key":"2023033014150842800_","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1161\/CIRCEP.111.964205","article-title":"The acute effects of changes to AV delay on BP and stroke volume: potential implications for design of pacemaker optimization protocols","volume":"5","author":"Manisty","year":"2012","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2023033014150842800_","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1111\/jce.14681","article-title":"Left bundle branch pacing: a comprehensive review","volume":"31","author":"Ponnusamy","year":"2020","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2023033014150842800_","doi-asserted-by":"crossref","first-page":"172","DOI":"10.15420\/aer.2021.26","article-title":"ECG And pacing criteria for differentiating conduction system pacing from myocardial pacing","volume":"10","author":"Jastrz\u00eabski","year":"2021","journal-title":"Arrhythm Electrophysiol Rev"},{"key":"2023033014150842800_","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s11886-021-01585-1","article-title":"Left bundle branch area pacing: implant technique, definitions, outcomes, and complications","volume":"23","author":"Cano","year":"2021","journal-title":"Curr Cardiol Rep"},{"key":"2023033014150842800_","doi-asserted-by":"crossref","first-page":"165","DOI":"10.15420\/aer.2021.21","article-title":"Physiology and practicality of left ventricular septal pacing","volume":"10","author":"Heckman","year":"2021","journal-title":"Arrhythm Electrophysiol Rev"},{"key":"2023033014150842800_","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ijcard.2018.06.005","article-title":"Response to cardiac resynchronization therapy is determined by intrinsic electrical substrate rather than by its modification","volume":"270","author":"Strik","year":"2018","journal-title":"Int J Cardiol"}],"container-title":["EP Europace"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/25\/3\/1060\/49703696\/euac245.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/article-pdf\/25\/3\/1060\/49703696\/euac245.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T07:13:54Z","timestamp":1701501234000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/25\/3\/1060\/7025387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,3]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2,3]]},"published-print":{"date-parts":[[2023,3,30]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euac245","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,3,1]]},"published":{"date-parts":[[2023,2,3]]}}}