{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:23:37Z","timestamp":1788942217642,"version":"build-2803163510"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","award":["PI20\/00693"],"award-info":[{"award-number":["PI20\/00693"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","award":["CIBERCV16"],"award-info":[{"award-number":["CIBERCV16"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","award":["CB16\/11\/00354"],"award-info":[{"award-number":["CB16\/11\/00354"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca"},{"name":"the Recognized Research Group","award":["2017-SGR-01548"],"award-info":[{"award-number":["2017-SGR-01548"]}]},{"name":"the CERCA Programme\/Generalitat de Catalunya"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Heterogeneous tissue channels (HTCs) detected by late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) are related to ventricular arrhythmias, but there are few published data about their arrhythmogenic characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We enrolled 34 consecutive patients with ischaemic and non-ischaemic cardiomyopathy who were referred for ventricular tachycardia (VT) ablation. LGE-CMR was performed prior to ablation, and the HTCs were analyzed. Arrhythmogenic HTCs linked to induced VT were identified during the VT ablation procedure. The characteristics of arrhythmogenic HTCs were compared with those of non-arrhythmogenic HTCs. Three patients were excluded due to low-quality LGE-CMR images. A total of 87 HTCs were identified on LGE-CMR in 31 patients (age:63.8 \u00b1 12.3 years; 96.8% male; left ventricular ejection fraction: 36.1 \u00b1 10.7%). Of the 87 HTCs, only 31 were considered arrhythmogenic because of their relation to a VT isthmus. The HTCs related to a VT isthmus were longer [64.6 \u00b1 49.4 vs. 32.9 \u00b1 26.6 mm; OR: 1.02; 95% CI: (1.01\u20131.04); P &amp;lt; 0.001] and had greater mass [2.5 \u00b1 2.2 vs. 1.2 \u00b1 1.2 grams; OR: 1.62; 95% CI: (1.18\u20132.21); P &amp;lt; 0.001], a higher degree of protectedness [26.19 \u00b1 19.2 vs. 10.74 \u00b1 8.4; OR 1.09; 95% CI: (1.04\u20131.14); P &amp;lt; 0.001], higher transmurality [number of wall layers with CCs: 3.8 \u00b1 2.4 vs. 2.4 \u00b1 2.0; OR: 1.31; 95% CI: (1.07\u20131.60); P = 0.008] and more ramifications [3.8 \u00b1 2.0 vs. 2.7 \u00b1 1.1; OR: 1.59; 95% CI: (1.15\u20132.19); P = 0.002] than non-arrhythmogenic HTCs. Multivariate logistic regression analysis revealed that protectedness was the strongest predictor of arrhythmogenicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The protectedness of an HTC identified by LGE-CMR is strongly related to its arrhythmogenicity during VT ablation.<\/jats:p><\/jats:sec>","DOI":"10.1093\/europace\/euac257","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T14:13:13Z","timestamp":1673014393000},"page":"989-999","source":"Crossref","is-referenced-by-count":43,"title":["Scar conducting channel characterization to predict arrhythmogenicity during ventricular tachycardia ablation"],"prefix":"10.1093","volume":"25","author":[{"given":"Paula","family":"Sanchez-Somonte","sequence":"first","affiliation":[{"name":"Cardiology Department, Institut Clinic Cardiovascular, Universitat de Barcelona, Hospital Clinic, Villarroel 170, 08036 , Barcelona , Spain"},{"name":"Cardiology Department, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Hospital Clinic, Villarroel 170, 08036, Barcelona , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , Av.Monforte de Lemos, 3-5. Pabellon 11. Planta 0. 29029, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0191-2776","authenticated-orcid":false,"given":"Paz","family":"Garre","sequence":"additional","affiliation":[{"name":"Cardiology Department, Institut Clinic Cardiovascular, Universitat de Barcelona, Hospital Clinic, Villarroel 170, 08036 , Barcelona , Spain"},{"name":"Cardiology Department, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Hospital Clinic, Villarroel 170, 08036, Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"V\u00e1zquez-Calvo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Institut Clinic Cardiovascular, Universitat de Barcelona, Hospital Clinic, Villarroel 170, 08036 , Barcelona , Spain"},{"name":"Cardiology Department, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Hospital Clinic, Villarroel 170, 08036, Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levio","family":"Quinto","sequence":"additional","affiliation":[{"name":"Cardiology Department, Institut Clinic Cardiovascular, Universitat de Barcelona, Hospital Clinic, Villarroel 170, 08036 , Barcelona , Spain"},{"name":"Cardiology Department, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Hospital Clinic, Villarroel 170, 08036, Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8585-2522","authenticated-orcid":false,"given":"Roger","family":"Borr\u00e0s","sequence":"additional","affiliation":[{"name":"Cardiology Department, Institut Clinic Cardiovascular, Universitat de Barcelona, Hospital Clinic, Villarroel 170, 08036 , Barcelona , Spain"},{"name":"Cardiology Department, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Hospital Clinic, Villarroel 170, 08036, Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Prat","sequence":"additional","affiliation":[{"name":"Cardiology Department, Institut Clinic Cardiovascular, Universitat de Barcelona, Hospital Clinic, Villarroel 170, 08036 , Barcelona , Spain"},{"name":"Cardiology Department, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Hospital Clinic, Villarroel 170, 08036, Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8043-6055","authenticated-orcid":false,"given":"Jose T","family":"Ortiz-Perez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Institut Clinic Cardiovascular, Universitat de Barcelona, Hospital Clinic, Villarroel 170, 08036 , Barcelona , Spain"},{"name":"Cardiology Department, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Hospital Clinic, Villarroel 170, 08036, Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5612-2814","authenticated-orcid":false,"given":"Martin","family":"Stegh\u00f6fer","sequence":"additional","affiliation":[{"name":"Adas3D Medical S.L , C\/Paris 179, 08036, Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5980-2508","authenticated-orcid":false,"given":"Rosa M","family":"Figueras i Ventura","sequence":"additional","affiliation":[{"name":"Adas3D Medical S.L , C\/Paris 179, 08036, Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4238-5319","authenticated-orcid":false,"given":"Eduard","family":"Guasch","sequence":"additional","affiliation":[{"name":"Cardiology Department, Institut Clinic Cardiovascular, Universitat de Barcelona, Hospital Clinic, Villarroel 170, 08036 , Barcelona , Spain"},{"name":"Cardiology Department, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Hospital Clinic, Villarroel 170, 08036, Barcelona , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , Av.Monforte de Lemos, 3-5. Pabellon 11. Planta 0. 29029, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1215-3472","authenticated-orcid":false,"given":"Jos\u00e9 Maria","family":"Tolosana","sequence":"additional","affiliation":[{"name":"Cardiology Department, Institut Clinic Cardiovascular, Universitat de Barcelona, Hospital Clinic, Villarroel 170, 08036 , Barcelona , Spain"},{"name":"Cardiology Department, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Hospital Clinic, Villarroel 170, 08036, Barcelona , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , Av.Monforte de Lemos, 3-5. Pabellon 11. Planta 0. 29029, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0424-6393","authenticated-orcid":false,"given":"Elena","family":"Arbelo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Institut Clinic Cardiovascular, Universitat de Barcelona, Hospital Clinic, Villarroel 170, 08036 , Barcelona , Spain"},{"name":"Cardiology Department, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Hospital Clinic, Villarroel 170, 08036, Barcelona , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , Av.Monforte de Lemos, 3-5. Pabellon 11. Planta 0. 29029, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5662-8302","authenticated-orcid":false,"given":"Josep","family":"Brugada","sequence":"additional","affiliation":[{"name":"Cardiology Department, Institut Clinic Cardiovascular, Universitat de Barcelona, Hospital Clinic, Villarroel 170, 08036 , Barcelona , Spain"},{"name":"Cardiology Department, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Hospital Clinic, Villarroel 170, 08036, Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1300-4732","authenticated-orcid":false,"given":"Marta","family":"Sitges","sequence":"additional","affiliation":[{"name":"Cardiology Department, Institut Clinic Cardiovascular, Universitat de Barcelona, Hospital Clinic, Villarroel 170, 08036 , Barcelona , Spain"},{"name":"Cardiology Department, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Hospital Clinic, Villarroel 170, 08036, Barcelona , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , Av.Monforte de Lemos, 3-5. 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Planta 0. 29029, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0731-3731","authenticated-orcid":false,"given":"Ivo","family":"Roca-Luque","sequence":"additional","affiliation":[{"name":"Cardiology Department, Institut Clinic Cardiovascular, Universitat de Barcelona, Hospital Clinic, Villarroel 170, 08036 , Barcelona , Spain"},{"name":"Cardiology Department, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Hospital Clinic, Villarroel 170, 08036, Barcelona , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , Av.Monforte de Lemos, 3-5. Pabellon 11. Planta 0. 29029, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"2023033021232064400_","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1093\/eurheartj\/ehs007","article-title":"Catheter ablation of ventricular tachycardia in ischaemic and non-ischaemic cardiomyopathy: where are we today? 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ablation","volume":"4","author":"Andreu","year":"2011","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"key":"2023033021232064400_","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.hrthm.2021.02.016","article-title":"Ventricular tachycardia burden reduction after substrate ablation: predictors of recurrence","volume":"18","author":"Quinto","year":"2021","journal-title":"Heart Rhythm"},{"key":"2023033021232064400_","first-page":"172","article-title":"MRI-Guided Ventricular tachycardia ablation","volume":"4","author":"Dickfeld","year":"2011","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"key":"2023033021232064400_","first-page":"528","article-title":"Three-Dimensional architecture of scar and conducting channels based on high resolution ce-CMR","volume":"6","author":"Fern\u00e1ndez-Armenta","year":"2013","journal-title":"Circulation: Arrhythmia and 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